receptor antagonist (pKi
values are 8.3, 7.66 and 6.77 for 5-HT2B
respectively). Increases wakefulness and motor activity in rats. Orally active.
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Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated.
Kennett et al.
Attenuation of haloperidol-induced catalepsy by a 5-HT2C receptor antagonist.
Reavill et al.
Increased wakefulness, motor activity and decreased theta activity after blockade of the 5-HT2B receptor by the subtype-selective antagonist SB-215505.
Kantor et al.