SB 334867

Catalog # Availability Size / Price Qty
SB 334867 | CAS No. 792173-99-0 | OX1 Receptor Antagonists
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Description: Selective non-peptide OX1 antagonist

Chemical Name: N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl urea

Purity: ≥99%

Product Details
Citations (48)
Supplemental Products

Biological Activity

SB 334867 is a selective non-peptide orexin OX1 receptor antagonist. pKb values are 7.2 and < 5 for inhibition of intracellular Ca2+ release in CHO cells expressing human OX1 and OX2 receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.

Technical Data

Soluble to 100 mM in DMSO with gentle warming and to 10 mM in ethanol with gentle warming
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline

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Citations for SB 334867

The citations listed below are publications that use Tocris products. Selected citations for SB 334867 include:

48 Citations: Showing 1 - 10

  1. Orexin modulates behavioral fear expression through the locus coeruleus.
    Authors: Soya
    Nat Commun  2017;8(1):1606
  2. Theta synchronization between medial prefrontal cortex and cerebellum is associated with adaptive performance of associative learning behavior.
    Authors: Chen Et al.
    Sci Rep  2016;6:20960
  3. Hypothalamic orexin's role in exacerbated cutaneous vasodilation responses to an anxiogenic stimulus in a surgical menopause model.
    Authors: Federici Et al.
    Psychoneuroendocrinology  2016;65:127
  4. Upregulation of orexin receptor in paraventricular nucleus promotes sympathetic outflow in obese Zucker rats.
    Authors: Zhou Et al.
    Neuropharmacology  2015;99:481
  5. Antagonistic interplay between hypocretin and leptin in the lateral hypothalamus regulates stress responses.
    Authors: Bonnavion Et al.
    Nat Commun  2015;6:6266
  6. Hypocretin/Orexin regulation of DA signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1.
    Authors: Prince Et al.
    ACS Chem Neurosci  2015;6:138
  7. Perifornical hypothalamic orexin and serotonin modulate the counterregulatory response to hypoglycemic and glucoprivic stimuli.
    Authors: Otlivanchik Et al.
    Neurosci Lett  2015;64:226
  8. Orexin/Hypocretin-1 Receptor Antagonism Selectively Reduces Cue-Induced Feeding in Sated Rats and Recruits Medial Prefrontal Cortex and Thalamus.
    Authors: Cole Et al.
    J Neurosci  2015;5:16143
  9. Hippocampus ghrelin signaling mediates appetite through lateral hypothalamic orexin pathways.
    Authors: Hsu Et al.
    Elife  2015;4
  10. Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
    Authors: Navarro Et al.
    Neuropsychopharmacology  2015;35:6639
  11. Orexinergic neurotransmission in temperature responses to metha. and stress: mathematical modeling as a data assimilation approach.
    Authors: Behrouzvaziri Et al.
    PLoS One  2015;10:e0126719
  12. Hepatic branch vagus nerve plays a critical role in the recovery of post-ischemic glucose intolerance and mediates a neuroprotective effect by hypothalamic orexin-A.
    Authors: Harada Et al.
    PLoS One  2014;9:e95433
  13. Orexin-A promotes cell migration in cultured rat astrocytes via Ca2+-dependent PKCα and ERK1/2 signals.
    Authors: Shu Et al.
    PLoS One  2014;9:e95259
  14. Acute high fat diet consumption activates the mesolimbic circuit and requires orexin signaling in a mouse model.
    Authors: Valdivia Et al.
    PLoS One  2014;9:e87478
  15. Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.
    Authors: Karasawa Et al.
    Neurosci Lett  2014;576:88
  16. The hypocretin/orexin system mediates the extinction of fear memories.
    Authors: Flores Et al.
    Neuropsychopharmacology  2014;39:2732
  17. Attenuated orexinergic signaling underlies depression-like responses induced by daytime light deficiency.
    Authors: Deats Et al.
    Neuroscience  2014;272:252
  18. Hindbrain orexin 1 receptors influence palatable food intake, operant responding for food, and food-conditioned place preference in rats.
    Authors: Kay Et al.
    Psychopharmacology (Berl)  2014;231:419
  19. Orexin A Affects INS-1 Rat Insoma Cell Proliferation via Orexin Receptor 1 and the AKT Signaling Pathway.
    Authors: Chen Et al.
    Int J Endocrinol  2014;2013:854623
  20. Calcium affects OX1 orexin (hypocretin) receptor responses by modifying both orexin binding and the signal transduction machinery.
    Authors: Putula Et al.
    Br J Pharmacol  2014;171:5816
  21. Chemical stimulation of the lateral hypothalamus potentiated the sensitization to mor. in rats: involvement of orexin-1 receptor in the ventral tegmental area.
    Authors: Razavi Et al.
    EXCLI J  2014;13:1120
  22. Circadian rhythm disruption by a novel running wheel: roles of exercise and arousal in blockade of the luteinizing hormone surge.
    Authors: Duncan Et al.
    Physiol Behav  2014;131:7
  23. Orexin receptors within the nucleus accumbens shell mediate the stress but not drug priming-induced reinstatement of mor. conditioned place preference.
    Authors: Qi Et al.
    Front Behav Neurosci  2013;7:144
  24. A role for hypocretin/orexin receptor-1 in cue-induced reinstatement of nicotine-seeking behavior.
    Authors: Plaza-Zabala Et al.
    Diabetes  2013;38:1724
  25. Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats.
    Authors: Mahler Et al.
    Psychopharmacology (Berl)  2013;226:687
  26. The dual orexin/hypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administration.
    Authors: Srinivasan Et al.
    PLoS One  2012;7:e44726
  27. Hypothalamic orexin--a neurons are involved in the response of the brain stress system to mor. withdrawal.
    Authors: Laorden Et al.
    PLoS One  2012;7:e36871
  28. Local hypocretin-1 modulates terminal DA concentration in the nucleus accumbens shell.
    Authors: Patyal Et al.
    Front Behav Neurosci  2012;6:82
  29. Activation of the orexin 1 receptor is a critical component of CO2-mediated anxiety and hypertension but not bradycardia.
    Authors: Johnson Et al.
    BMC Complement Altern Med  2012;37:1911
  30. Occurrence of epilepsy at different zeitgeber times alters sleep homeostasis differently in rats.
    Authors: Yi Et al.
    Sleep  2012;35:1651
  31. Orexinergic signaling mediates light-induced neuronal activation in the dorsal raphe nucleus.
    Authors: Adidharma Et al.
    Neuroscience  2012;220:201
  32. Orexin A in rat rostral ventrolateral medulla is pressor, sympatho-excitatory, increases barosensitivity and attenuates the somato-sympathetic reflex.
    Authors: Shahid Et al.
    Br J Pharmacol  2012;165:2292
  33. Orexin-1 receptor antagonism does not reduce the rewarding potency of cocaine in Swiss-Webster mice.
    Authors: Riday Et al.
    Brain Res  2012;1431:53
  34. Involvement of spinal orexin A in the electroacupuncture analgesia in a rat model of post-laparotomy pain.
    Authors: Feng Et al.
    Brain Res  2012;12:225
  35. Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network.
    Authors: Johnson Et al.
    Sci Rep  2012;107:733
  36. The role of orexin-1 receptors in physiologic responses evoked by microinjection of PgE2 or muscimol into the medial preoptic area.
    Authors: Rusyniak Et al.
    J Neuroinflammation  2011;498:162
  37. An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.
    Authors: Tupone Et al.
    J Neurosci  2011;31:15944
  38. Evidence for the role of hindbrain orexin-1 receptors in the control of meal size.
    Authors: Parise Et al.
    Am J Physiol Regul Integr Comp Physiol  2011;301:R1692
  39. Glutamatergic regulation of ghrelin-induced activation of the mesolimbic DA system.
    Authors: Jerlhag Et al.
    Addict Biol  2011;16:82
  40. Intrathecal orexin A increases sympathetic outflow and respiratory drive, enhances baroreflex sensitivity and blocks the somato-sympathetic reflex.
    Authors: Shahid Et al.
    Br J Pharmacol  2011;162:961
  41. Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.
    Authors: Heydendael Et al.
    Endocrinology  2011;152:4738
  42. The hypocretin-orexin system regulates cocaine self-administration via actions on the mesolimbic DA system.
    Authors: Espa&ntilde;a Et al.
    Eur J Neurosci  2010;31:336
  43. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.
    Authors: Malherbe Et al.
    Br J Pharmacol  2009;156:1326
  44. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity.
    Authors: Gompf and Aston-Jones
    Neuropsychopharmacology  2008;1224:43
  45. Insular hypocretin transmission regulates nicotine reward.
    Authors: Hollander Et al.
    Proc Natl Acad Sci U S A  2008;105:19480
  46. Contribution of orexin in hypercapnic chemoreflex: evidence from genetic and pharmacological disruption and supplementation studies in mice.
    Authors: Deng Et al.
    J Appl Physiol (1985)  2007;103:1772
  47. Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons.
    Authors: Sasson Et al.
    Neuroendocrinology  2006;84:353
  48. Hypocretin-1 dose-dependently modulates maternal behaviour in mice.
    Authors: D&#39;Anna and Gammie
    J Neuroendocrinol  2006;18:553


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