Selective non-peptide orexin OX1
receptor antagonist. pKb
values are 7.2 and < 5 for inhibition of intracellular Ca2+
release in CHO cells expressing human OX1
receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo
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Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement.
Duxon et al.
A selective orexin-1 receptor antagonist reduces food consumption in male and female rats.
Haynes et al.
SB-334867-A: the first selective orexin-1 receptor antagonist.
Smart et al.
1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor.
Porter et al.
The citations listed below are publications that use Tocris products. Selected citations for SB 334867 include:
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