SB 415286

  ( 24 citations )    
Product Datasheet
Catalog Number:1617
Chemical Name:3-[(3-Chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-1H-pyrrole-2,5-dione
Product Details
Citations (24)
Reviews
Biological Activity
Potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC50 > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
Technical Data
  • M.Wt:
    359.73
  • Formula:
    C16H10ClN3O5
  • Solubility:
    Soluble to 25 mM in ethanol and to 50 mM in DMSO
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    264218-23-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SB 415286 include:

24 Citations: Showing 1 - 10
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  1. Pharmacologically blocking p53-dependent apoptosis protects intestinal stem cells and mice from radiation.
    Authors: Wang Et al.
    Sci Rep  2015;5:8566
  2. Resveratrol regulates naïve CD 8+ T-cell proliferation by upregulating IFN-γ-induced tryptophanyl-tRNA synthetase expression.
    Authors: Noh Et al.
    BMB Rep  2015;48:283
  3. GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling.
    Authors: Stretton Et al.
    J Biol Chem  2015;470:207
  4. Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β.
    Authors: Vossel Et al.
    Biochem J  2015;209:419
  5. GSK3β Inhibition Promotes Synaptogenesis in Drosophila and Mammalian Neurons.
    Authors: Cuesto Et al.
    PLoS One  2015;10:e0118475
  6. Sequential dosing in chemosensitization: targeting the PI3K/Akt/mTOR pathway in neuroblastoma.
    Authors: Westhoff Et al.
    PLoS One  2014;8:e83128
  7. Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells.
    Authors: Acevedo Et al.
    Hum Mol Genet  2014;289:11007
  8. Inhibiting glycogen synthase kinase-3 mitigates the hematopoietic acute radiation syndrome in mice.
    Authors: Lee Et al.
    Radiat Res  2014;181:445
  9. Tristetraprolin mediates radiation-induced TNF-α production in lung macrophages.
    Authors: Ray Et al.
    PLoS One  2013;8:e57290
  10. Anti-dengue virus nonstructural protein 1 antibodies cause NO-mediated endothelial cell apoptosis via ceramide-regulated glycogen synthase kinase-3β and NF-κB activation.
    Authors: Chen Et al.
    J Immunol  2013;191:1744
  11. Sidestream smoke exposure increases the susceptibility of airway epithelia to adenoviral infection.
    Authors: Sharma Et al.
    PLoS One  2012;7:e49930
  12. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway.
    Authors: Thotala Et al.
    Cell Death Differ  2012;19:387
  13. Glycogen synthase kinase 3β inhibition enhances repair of DNA double-strand breaks in irradiated hippocampal neurons.
    Authors: Yang Et al.
    Nature  2011;13:459
  14. A new class of molecular targeted radioprotectors: GSK-3beta inhibitors.
    Authors: Thotala Et al.
    Int J Radiat Oncol Biol Phys  2010;76:557
  15. Molecular imaging of glycogen synthase kinase-3beta and casein kinase-1alpha kinases.
    Authors: Nyati Et al.
    Anal Biochem  2010;405:246
  16. Glycogen Synthase Kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression.
    Authors: Severson Et al.
    Neuro Oncol  2010;397:592
  17. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms.
    Authors: Tsai Et al.
    Neuropsychopharmacology  2010;35:2225
  18. Phosphorylation of CLASP2 by GSK-3beta regulates its interaction with IQGAP1, EB1 and microtubules.
    Authors: Watanabe Et al.
    J Cell Sci  2009;122:2969
  19. Microtubule stabilization specifies initial neuronal polarization.
    Authors: Witte Et al.
    J Cell Biol  2008;180:619
  20. Cdc42 regulates cofilin during the establishment of neuronal polarity.
    Authors: Garvalov Et al.
    J Neurosci  2007;27:13117
  21. Phosphatidylinositol 3-kinase regulation of gastrin-releasing peptide-induced cell cycle progression in neuroblastoma cells.
    Authors: Ishola Et al.
    Biochem Biophys Res Commun  2007;1770:927
  22. Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localization of polycystin-2 in vivo and in vitro.
    Authors: Streets Et al.
    Biochim Biophys Acta  2006;15:1465
  23. Neuronal polarity is regulated by glycogen synthase kinase-3 (GSK-3beta) independently of Akt/PKB serine phosphorylation.
    Authors: Gärtner Et al.
    J Cell Sci  2006;119:3927
  24. Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts.
    Authors: Gross Et al.
    Circ Res  2004;94:960
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