SB 415286

Key Product Details

Product Description

SB 415286 is a potent and selective glycogen synthase kinase-3 (GSK-3) inhibitor (K_i = 31 nM for GSK-3α); competes with ATP. Has minimal activity against 24 other protein kinases (IC₅₀ > 10 μ M). Stimulates glycogen synthesis, gene transcription and is neuroprotective.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 415286

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 415286

The following data is based on the product molecular weight 359.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.56 mL	27.80 mL	55.60 mL
2.5 mM	1.11 mL	5.56 mL	11.12 mL
5 mM	0.56 mL	2.78 mL	5.56 mL
25 mM	0.11 mL	0.56 mL	1.11 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 109 publications citing the usage of this product.

• Cross Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. J.Neurochem. 2001 PMID: 11279265
• Liang and Chuang Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. J.Biol.Chem. 2006 PMID: 17148450
• Coghlan Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. Chem.Biol. 2000 PMID: 11033082

Product Documents for SB 415286