SB 611812
Discontinued Product
Chemical Name: 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
Purity: ≥99%
Biological Activity
SB 611812 is an urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease.
Bousette et al.
Peptides, 2006;27:2919 -
Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation.
Bousette et al.
J.Mol.Cell Cardiol., 2006;41:285 -
Urotensin-II and cardiovascular remodeling.
Papadopoulos et al.
Peptides, 2008;29:764
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