Catalog Number: 4670
Chemical Name: 2,6-Dichloro-N-[4-chloro-3-[2-(dimethylamino)ethoxy]phenyl]-4-(trifluoromethyl)benzenesulfonamide
Biological Activity
Urotensin-II (UT) antagonist. Inhibits urotensin-II-induced proliferation of neonatal cardiac fibroblasts. Attenuates cardiac dysfunction in a rat model of coronary artery ligation; decreases cardiomyocyte hypertrophy, ventricular dilatation and cardiac remodeling.
Technical Data
  • M.Wt:
    491.74
  • Formula:
    C17H16Cl3F3N2O3S
  • Solubility:
    Soluble to 10 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    345892-71-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold for research purposes under agreement from GlaxoSmithKline.
Background References
  1. Urotensin-II receptor blockade with SB-611812 attenuates cardiac remodeling in experimental ischemic heart disease.
    Bousette et al.
    Peptides, 2006;27:2919
  2. Urotensin-II blockade with SB-611812 attenutes cardiac dysfunction in a rat model of coronary artery ligation.
    Bousette et al.
    J.Mol.Cell Cardiol., 2006;41:285
  3. Urotensin-II and cardiovascular remodeling.
    Papadopoulos et al.
    Peptides, 2008;29:764

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