SBE 13 hydrochloride

   
Product Datasheet
Catalog Number:4292
Chemical Name:N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
Product Details
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Biological Activity
Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.
Technical Data
  • M.Wt:
    479.4
  • Formula:
    C24H27ClN2O4.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at RT
  • CAS No:
    1052532-15-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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