Catalog Number: 4292
Chemical Name: N-[[4-[(6-Chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxybenzeneethanamine hydrochloride
Biological Activity
Selective inhibitor of PLK1 (IC50 values are 200 pM, 875 nM and 66 μM for PLK1, PLK3 and PLK2 respectively). Exhibits no effect on Aurora kinase A activity. Binds and stabilizes the inactive form of PLK1. Delays cell cycle progression, reduces cell proliferation and induces apoptosis in a range of human cancer cell lines. Transiently arrests cells cycle at G0/G1 in primary cells.
Technical Data
  • M.Wt:
    479.4
  • Formula:
    C24H27ClN2O4.HCl
  • Solubility:
    Soluble to 10 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at RT
  • CAS No:
    1052532-15-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Freezing Polo in its sleep: targeting the inactive conformation of Polo-like kinase 1 in cancer cells.
    Eckerdt
    Cell Cycle, 2010;9:862
  2. Biological impact of freezing Plk1 in its inactive conformation in cancer cells.
    Keppner et al.
    Cell Cycle, 2010;9:761
  3. SBE13 joins the family of Polo-like kinase 1 (Plk1) inhibitors.
    Liu
    Cell Cycle, 2010;9:445
  4. Fate of primary cells at the G1/S boundary after Polo-like kinase 1 inhibition by SBE13.
    Keppner et al.
    Cell Cycle, 2011;10:708
  5. Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1.
    Keppner et al.
    ChemMedChem, 2009;4:1806

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