SCH 23390 hydrochloride

  ( 48 citations )    
Product Datasheet
Catalog Number:0925
Alternate Names:(R)-(+)-SCH 23390 hydrochloride
Chemical Name:(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
Product Details
Citations (48)
Supplemental Products
Reviews
Biological Activity
Potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT1C and 5-HT2C receptors in vitro (Ki values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.
Technical Data
  • M.Wt:
    324.24
  • Formula:
    C17H18ClNO.HCl
  • Solubility:
    Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol
  • Purity:
    >98
  • Storage:
    Desiccate at +4°C
  • CAS No:
    125941-87-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SCH 23390 hydrochloride include:

48 Citations: Showing 1 - 10
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  1. Fasting biases μ-opioid receptors toward β-arrestin2 dependent signaling in the accumbens shell.
    Authors: Scheggi
    Neuroscience  2017;352:19
  2. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  3. Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  4. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons.
    Authors: Beckley Et al.
    J Neurosci  2016;36:701
  5. The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
    Authors: Kasaharaa Et al.
    Neuroscience  2016;340:176
  6. Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
    Authors: Fritz Et al.
    J Clin Invest  2016;126:695
  7. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  8. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway.
    Authors: Hao Et al.
    Cell Death Dis  2015;6:e1965
  9. Retroactive modulation of spike timing-dependent plasticity by dopamine.
    Authors: Brzosko Et al.
    Elife  2015;4
  10. Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons.
    Authors: Li Et al.
    Learn Mem  2015;35:8232
  11. Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim Et al.
    J Neurosci  2015;35:6307
  12. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    PLoS One  2015;352:53
  13. Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
    Authors: Pezze Et al.
    Behav Neurosci  2015;232:2669
  14. Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
    Authors: Savalli Et al.
    PLoS One  2015;22:69
  15. A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence.
    Authors: Marchant and Kaganovsky
    PLoS One  2015;129:281
  16. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    J Pharmacol Exp Ther  2015;10:e0140369
  17. Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs.
    Authors: Lee and Chirwa
    Nat Neurosci  2015;10:e0135578
  18. Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    PLoS One  2015;10:e0124986
  19. Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
    Authors: Meunier Et al.
    PLoS One  2015;10:e0120286
  20. Phasic dopamine release drives rapid activation of striatal D2-receptors.
    Authors: Marcott Et al.
    Neuron  2014;84:164
  21. Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective dopaminergic drugs and methamphetamine.
    Authors: Lee Et al.
    Synapse  2014;68:221
  22. Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
    Authors: Zhao Et al.
    Br J Pharmacol  2014;38:256
  23. Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  24. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
    Authors: Ribeiro Et al.
    J Neurosci  2014;23:2030
  25. Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
    Authors: Fuenzalida Et al.
    J Clin Invest  2014;171:5650
  26. Age-dependent regulation of synaptic connections by dopamine D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  27. Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians.
    Authors: Zhang Et al.
    Physiol Behav  2013;112-113:8
  28. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    Authors: Huang Et al.
    Neuroscience  2012;7:e49954
  29. Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
    Authors: Prado Et al.
    Psychopharmacology (Berl)  2012;188:3062
  30. Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.
    Authors: Lisek Et al.
    Drug Alcohol Depend  2012;126:257
  31. Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
    Authors: Krishnan Et al.
    PLoS One.  2011;6:e25639
  32. Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic d1 receptor.
    Authors: Shin Et al.
    Hum Mol Genet  2011;20:130
  33. Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.
    Authors: Krishnan Et al.
    Eur J Neurosci  2010;31:1027
  34. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci  2010;30:2935
  35. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.
    Authors: Schwendt and McGinty
    J Neurosci  2010;168:96
  36. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Ginseng Res  2010;13:1128
  37. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.
    Authors: Xu Et al.
    Exp Neurobiol  2010;115:1643
  38. Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.
    Authors: Raghuraman Et al.
    J Neurochem  2010;115:1568
  39. Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
    Authors: Xu Et al.
    J Immunol  2009;29:14086
  40. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  41. Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.
    Authors: Ma Et al.
    J Neurophysiol  2009;101:2230
  42. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  43. Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    J Neurochem  2008;28:13856
  44. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
    Authors: Clancy Et al.
    PLoS One  2007;27:6388
  45. Cellular localization and function of DARPP-32 in the rodent retina.
    Authors: Witkovsky Et al.
    Eur J Neurosci  2007;25:3233
  46. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
    Authors: Nackley Et al.
    Pain  2007;128:199
  47. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    J Neurosci  2007;117:4022
  48. Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
    Authors: Meredith Et al.
    Proc Natl Acad Sci U S A  2006;103:13485
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