SCH 23390 hydrochloride

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0925/10
0925/50
SCH 23390 hydrochloride | CAS No. 125941-87-9 | Dopamine D1 and D5 Receptor Antagonists
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Description: Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Alternative Names: (R)-(+)-SCH 23390 hydrochloride

Chemical Name: (R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

Purity: ≥98%

Product Details
Citations (58)
Supplemental Products
Reviews

Biological Activity

SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT2C receptors in vitro (Ki values are 6.3 - 9.3 nM). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

Technical Data

M.Wt:
324.24
Formula:
C17H18ClNO.HCl
Solubility:
Soluble to 100 mM in water with gentle warming and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
125941-87-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SCH 23390 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for SCH 23390 hydrochloride include:

58 Citations: Showing 1 - 10

  1. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
    Authors: Dorst Et al.
    Nat Commun  2020;11:5113
  2. DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
    Authors: Zhang Et al.
    Invest Ophthalmol Vis Sci  2018;59(11):4441
  3. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  4. Altered Baseline and Nicotine-Mediated Behavioral and Cholinergic Profiles in ChAT-Cre Mouse Lines.
    Authors: Chen Et al.
    J Neurosci  2018;38:2177
  5. DA Cells Differentially Regulate Striatal Cholinergic Transmission across Regions through Corelease of DA and Glutamate.
    Authors: Cai and Ford
    Cell Rep  2018;25:3148
  6. The small molecule CA140 inhibits the neuroinflammatory response in wild-type mice and a mouse model of AD.
    Authors: Lee Et al.
    J Neuroinflammation  2018;15:286
  7. Fasting biases μ-opioid receptors toward β-arrestin2 dependent signaling in the accumbens shell.
    Authors: Scheggi
    Neuroscience  2017;352:19
  8. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  9. Nicotinic and opioid receptor regulation of striatal DA D2-receptor mediated transmission
    Authors: Mamaligas Et al.
    Scientific Reports  2016;6:37834
  10. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons.
    Authors: Beckley Et al.
    J Neurosci  2016;36:701
  11. The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
    Authors: Kasaharaa Et al.
    Neuroscience  2016;340:176
  12. Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice.
    Authors: Fritz Et al.
    J Clin Invest  2016;126:695
  13. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  14. L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating DA D1 receptor/PKA signaling pathway.
    Authors: Hao Et al.
    Cell Death Dis  2015;6:e1965
  15. Retroactive modulation of spike timing-dependent plasticity by DA.
    Authors: Brzosko Et al.
    Elife  2015;4
  16. Incubation of metha. craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons.
    Authors: Li Et al.
    Learn Mem  2015;35:8232
  17. Spinal DArgic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
    Authors: Kim Et al.
    J Neurosci  2015;35:6307
  18. Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
    Authors: Conley Et al.
    PLoS One  2015;352:53
  19. DArgic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
    Authors: Pezze Et al.
    Behav Neurosci  2015;232:2669
  20. Regionally selective requirement for D1/D5 DArgic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
    Authors: Savalli Et al.
    PLoS One  2015;22:69
  21. A critical role of nucleus accumbens DA D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence.
    Authors: Marchant and Kaganovsky
    PLoS One  2015;129:281
  22. Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
    Authors: Montalbano Et al.
    J Pharmacol Exp Ther  2015;10:e0140369
  23. Blocking DArgic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs.
    Authors: Lee and Chirwa
    Nat Neurosci  2015;10:e0135578
  24. DA Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
    Authors: Rioult-Pedotti Et al.
    PLoS One  2015;10:e0124986
  25. Effect of DArgic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
    Authors: Meunier Et al.
    PLoS One  2015;10:e0120286
  26. Phasic DA release drives rapid activation of striatal D2-receptors.
    Authors: Marcott Et al.
    Neuron  2014;84:164
  27. Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective DArgic drugs and metha.
    Authors: Lee Et al.
    Synapse  2014;68:221
  28. Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons.
    Authors: Chen Et al.
    Alcohol Clin Exp Res  2014;38:777
  29. Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
    Authors: Zhao Et al.
    Br J Pharmacol  2014;38:256
  30. DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  31. Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
    Authors: Ribeiro Et al.
    J Neurosci  2014;23:2030
  32. DA D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
    Authors: Fuenzalida Et al.
    J Clin Invest  2014;171:5650
  33. Extinction of remotely acquired fear depends on an inhibitory NR2B/PKA pathway in the retrosplenial cortex.
    Authors: Corcoran Et al.
    J Neurosci  2013;33:19492
  34. Age-dependent regulation of synaptic connections by DA D2 receptors.
    Authors: Jia Et al.
    Nat Neurosci  2013;16:1627
  35. Sucrose produces withdrawal and DA-sensitive reinforcing effects in planarians.
    Authors: Zhang Et al.
    Physiol Behav  2013;112-113:8
  36. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    Authors: Huang Et al.
    Neuroscience  2012;7:e49954
  37. Stimulation of DA receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
    Authors: Prado Et al.
    Psychopharmacology (Berl)  2012;188:3062
  38. Mephedrone ('bath salt') elicits conditioned place preference and DA-sensitive motor activation.
    Authors: Lisek Et al.
    Drug Alcohol Depend  2012;126:257
  39. Synergistic activation of DA D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala.
    Authors: Li Et al.
    PLoS One  2011;6:e26065
  40. DA-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
    Authors: Krishnan Et al.
    PLoS One.  2011;6:e25639
  41. Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of DArgic d1 receptor.
    Authors: Shin Et al.
    Hum Mol Genet  2011;20:130
  42. DA receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.
    Authors: Krishnan Et al.
    Eur J Neurosci  2010;31:1027
  43. DA-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    J Neurosci  2010;30:2935
  44. Differential effects of selective adenosine antagonists on the effort-related impairments induced by DA D1 and D2 antagonism.
    Authors: Nunes Et al.
    Neuroscience  2010;170:268
  45. Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of DA and glucocorticoid receptors.
    Authors: Schwendt and McGinty
    J Neurosci  2010;168:96
  46. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Ginseng Res  2010;13:1128
  47. Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant.
    Authors: Xu Et al.
    Exp Neurobiol  2010;115:1643
  48. Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of DA D1 receptor signaling.
    Authors: Raghuraman Et al.
    J Neurochem  2010;115:1568
  49. HyperDArgic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
    Authors: Xu Et al.
    J Immunol  2009;29:14086
  50. DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  51. Activation of phosphatidylinositol-linked novel D1 DA receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.
    Authors: Ma Et al.
    J Neurophysiol  2009;101:2230
  52. Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
    Authors: Costa Et al.
    J Neurosci  2008;28:8040
  53. DA enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
    Authors: Kash Et al.
    J Neurochem  2008;28:13856
  54. Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
    Authors: Clancy Et al.
    PLoS One  2007;27:6388
  55. Cellular localization and function of DARPP-32 in the rodent retina.
    Authors: Witkovsky Et al.
    Eur J Neurosci  2007;25:3233
  56. Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
    Authors: Nackley Et al.
    Pain  2007;128:199
  57. Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
    Authors: Rao Et al.
    J Neurosci  2007;117:4022
  58. DA targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
    Authors: Meredith Et al.
    Proc Natl Acad Sci U S A  2006;103:13485

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