Potent dopamine receptor antagonist (K
values are 0.2 nM and 0.3 nM at D
receptor sub-types, respectively). Also an agonist at 5-HT
values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced K
3 (GIRK) currents (EC
= 268 nM) independently of receptors.
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The citations listed below are publications that use Tocris products.
Selected citations for SCH 23390 hydrochloride include:
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Fasting biases μ-opioid receptors toward β-arrestin2 dependent signaling in the accumbens shell.
Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
Aging Cell 2017;16(6):1323
Nicotinic and opioid receptor regulation of striatal dopamine D2-receptor mediated transmission
Authors: Mamaligas Et al.
Scientific Reports 2016;6:37834
The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens Dopamine D1 Receptor Neurons.
Authors: Beckley Et al.
J Neurosci 2016;36:701
The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
Authors: Kasaharaa Et al.
Prostaglandin-dependent modulation of dopaminergic neurotransmission elicits inflammation-induced aversion in mice.
Authors: Fritz Et al.
J Clin Invest 2016;126:695
Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
L-Stepholidine rescues memory deficit and synaptic plasticity in models of Alzheimer's disease via activating dopamine D1 receptor/PKA signaling pathway.
Authors: Hao Et al.
Cell Death Dis 2015;6:e1965
Retroactive modulation of spike timing-dependent plasticity by dopamine.
Authors: Brzosko Et al.
Incubation of methamphetamine craving is associated with selective increases in expression of Bdnf and trkb, glutamate receptors, and epigenetic enzymes in cue-activated fos-expressing dorsal striatal neurons.
Authors: Li Et al.
Learn Mem 2015;35:8232
Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism.
Authors: Kim Et al.
J Neurosci 2015;35:6307
Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.
Authors: Conley Et al.
PLoS One 2015;352:53
Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
Authors: Pezze Et al.
Behav Neurosci 2015;232:2669
Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
Authors: Savalli Et al.
PLoS One 2015;22:69
A critical role of nucleus accumbens dopamine D1-family receptors in renewal of alcohol seeking after punishment-imposed abstinence.
Authors: Marchant and Kaganovsky
PLoS One 2015;129:281
Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
Authors: Montalbano Et al.
J Pharmacol Exp Ther 2015;10:e0140369
Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs.
Authors: Lee and Chirwa
Nat Neurosci 2015;10:e0135578
Dopamine Promotes Motor Cortex Plasticity and Motor Skill Learning via PLC Activation.
Authors: Rioult-Pedotti Et al.
PLoS One 2015;10:e0124986
Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
Authors: Meunier Et al.
PLoS One 2015;10:e0120286
Phasic dopamine release drives rapid activation of striatal D2-receptors.
Authors: Marcott Et al.
Characterization of the guinea pig animal model and subsequent comparison of the behavioral effects of selective dopaminergic drugs and methamphetamine.
Authors: Lee Et al.
Korean Red Ginseng attenuates anxiety-like behavior during ethanol withdrawal in rats.
Authors: Zhao Et al.
Br J Pharmacol 2014;38:256
Dopaminergic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K
+, and T-type Ca 2+ channels.
Authors: Cilz Et al.
Cereb Cortex 2014;24:3195
Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
Authors: Ribeiro Et al.
J Neurosci 2014;23:2030
Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
Authors: Fuenzalida Et al.
J Clin Invest 2014;171:5650
Age-dependent regulation of synaptic connections by dopamine D2 receptors.
Authors: Jia Et al.
Nat Neurosci 2013;16:1627
Sucrose produces withdrawal and dopamine-sensitive reinforcing effects in planarians.
Authors: Zhang Et al.
Physiol Behav 2013;112-113:8
SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
Authors: Huang Et al.
Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity.
Authors: Prado Et al.
Psychopharmacology (Berl) 2012;188:3062
Mephedrone ('bath salt') elicits conditioned place preference and dopamine-sensitive motor activation.
Authors: Lisek Et al.
Drug Alcohol Depend 2012;126:257
Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
Authors: Krishnan Et al.
PLoS One. 2011;6:e25639
Exposure to extremely low frequency magnetic fields induces fos-related antigen-immunoreactivity via activation of dopaminergic d1 receptor.
Authors: Shin Et al.
Hum Mol Genet 2011;20:130
Dopamine receptor mechanisms mediate corticotropin-releasing factor-induced long-term potentiation in the rat amygdala following cocaine withdrawal.
Authors: Krishnan Et al.
Eur J Neurosci 2010;31:1027
Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
Authors: Goffin Et al.
J Neurosci 2010;30:2935
Amphetamine up-regulates activator of G-protein signaling 1 mRNA and protein levels in rat frontal cortex: the role of dopamine and glucocorticoid receptors.
Authors: Schwendt and McGinty
J Neurosci 2010;168:96
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
Authors: Deng Et al.
J Ginseng Res 2010;13:1128
Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperdopaminergic mutant.
Authors: Xu Et al.
Exp Neurobiol 2010;115:1643
Post-translational modification of glutamic acid decarboxylase 67 by intermittent hypoxia: evidence for the involvement of dopamine D1 receptor signaling.
Authors: Raghuraman Et al.
J Neurochem 2010;115:1568
Hyperdopaminergic tone erodes prefrontal long-term potential via a D2 receptor-operated protein phosphatase gate.
Authors: Xu Et al.
J Immunol 2009;29:14086
Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Authors: Chuhma Et al.
Activation of phosphatidylinositol-linked novel D1 dopamine receptors inhibits high-voltage-activated Ca2+ currents in primary cultured striatal neurons.
Authors: Ma Et al.
J Neurophysiol 2009;101:2230
Electrophysiology and pharmacology of striatal neuronal dysfunction induced by mitochondrial complex I inhibition.
Authors: Costa Et al.
J Neurosci 2008;28:8040
Dopamine enhances fast excitatory synaptic transmission in the extended amygdala by a CRF-R1-dependent process.
Authors: Kash Et al.
J Neurochem 2008;28:13856
Coregulation of natively expressed pertussis toxin-sensitive muscarinic receptors with G-protein-activated potassium channels.
Authors: Clancy Et al.
PLoS One 2007;27:6388
Cellular localization and function of DARPP-32 in the rodent retina.
Authors: Witkovsky Et al.
Eur J Neurosci 2007;25:3233
Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors.
Authors: Nackley Et al.
Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons.
Authors: Rao Et al.
J Neurosci 2007;117:4022
Dopamine targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
Authors: Meredith Et al.
Proc Natl Acad Sci U S A 2006;103:13485
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