SCH 23390 hydrochloride

Tocris Bioscience | Catalog # 0925

Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker
Tocris Bioscience

Key Product Details

Description

Selective D1-like antagonist; also 5-HT2C agonist and Kir3 channel blocker

Alternative Names

(R)-(+)-SCH 23390 hydrochloride
View all Dopamine D1 and D5 Receptor Antagonists »

Product Description

SCH 23390 hydrochloride is a potent dopamine receptor antagonist (Ki values are 0.2 nM and 0.3 nM at D1 and D5 receptor sub-types, respectively). Also an agonist at 5-HT2C receptors in vitro (Ki values are 6.3 - 9.3 nM). Blocks quinpirole-induced Kir3 (GIRK) currents (EC50 = 268 nM) independently of receptors.

Product Specifications for SCH 23390 hydrochloride

Molecular Weight

324.24

Formula

C17H18ClNO.HCl

Storage

Desiccate at +4°C

Purity

≥98% (HPLC)

Chemical Name

(R)-(+)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride

CAS Number

125941-87-9

PubChem ID

11957535

InChI Key

OYCAEWMSOPMASE-XFULWGLBSA-N

SMILES

ClC1=C(O)C=C([C@](C3=CC=CC=C3)([H])C2)C(CCN2C)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 32.42 100 with gentle warming
Ethanol 16.21 50

Preparing Stock Solutions for SCH 23390 hydrochloride

The following data is based on the product molecular weight 324.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.08 mL 15.42 mL 30.84 mL
5 mM 0.62 mL 3.08 mL 6.17 mL
10 mM 0.31 mL 1.54 mL 3.08 mL
50 mM 0.06 mL 0.31 mL 0.62 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 137 publications citing the usage of this product.

Product Documents for SCH 23390 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SCH 23390 hydrochloride

For research use only

Citations for SCH 23390 hydrochloride

Customer Reviews for SCH 23390 hydrochloride (3)

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  • Dopamine receptor antagonism
    Name: Sergiy Sylantyev
    Species: Human
    Cell Line/Tissue: Stem cell - derived neurons
    Verified Customer | Posted 10/15/2020
    SCH‐23390 was in use as a dopamine receptor antagonist. Being applied at stem cell – derived cultured neurons (10 nM concentration) together with sulpiride, caused an increase of amplitudes of evoked post-synaptic potentials generated by NMDA receptors (see illustration). Preparation of 10 mM water stocks requires sonication.
    SCH 23390 hydrochloride 0925
  • Effects of SCH 23390 on cue-induced reinstatement of food seeking
    Name: Kevin Ball
    Species: Rat
    Assay Type: In Vivo
    Verified Customer | Posted 01/22/2019
    At a dose that did not alter responding during food self-administration (6 micrograms/kg), systemic injections of SCH 23390 blocked responding during cue-induced reinstatement of food seeking tests.
    SCH 23390 hydrochloride 0925
  • A drug that affects locomotion
    Name: Luiz Alexandre Magno
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 10/26/2018
    Our lab has used SCH23390 to block dopaminergic D1 receptors and to check its effect on locomotion. Mice were injected with this drug and we noticed that SCH23390 decreased the average speed during a 5-minute test.
    SCH 23390 hydrochloride 0925

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