Potent dopamine receptor antagonist (Ki
values are 0.2 nM and 0.3 nM at D1
receptor sub-types, respectively). Also an agonist at 5-HT1C
receptors in vitro
values are 6.3 nM and 9.3 nM respectively). Blocks quinpirole-induced Kir
3 (GIRK) currents (EC50
= 268 nM) independently of receptors.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Activation of the 5-HT1C receptor expressed in Xenopus oocytes by the benzazepines SCH 23390 and SKF 38393.
Briggs et al.
SCH 23390: The first selective dopamine D1-like receptor antagonist.
Bourne et al.
CNS Drug Rev., 2001;7:399
The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist against cloned human serotonin2C receptors.
Millan et al.
Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels.
Kuzhikandathil and Oxford
The citations listed below are publications that use Tocris products. Selected citations for SCH 23390 hydrochloride include:
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