Catalog Number: 1251
Chemical Name: (S)-α-Amino-2',4'-dichloro-4-hydroxy-5-(phosphonomethyl)-[1,1'-biphenyl]-3-propanoic acid
Biological Activity
Potent competitive antagonist at the NMDA receptor (pKi = 8.5). Selective over a range of other receptor sites.
Technical Data
  • M.Wt:
    420.19
  • Formula:
    C16H16Cl2NO6P
  • Solubility:
    Soluble to 100 mM in DMSO
  • Storage:
    Store at RT
  • CAS No:
    174575-40-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Novartis Pharma AG
Background References
  1. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - I. Pharmacological characterization in vitro.
    Urwyler et al.
    Neuropharmacology, 1996;35:643
  2. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists - II. Pharmacological characterization in vivo.
    Urwyler et al.
    Neuropharmacology, 1996;35:655

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