Serotonin hydrochloride

Catalog # Availability Size / Price Qty
3547/50
Serotonin hydrochloride | CAS No. 153-98-0 | Non-selective 5-HT Receptor Agonists
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Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine, 5-HT

Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products
Reviews (1)

Biological Activity

Endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).

Technical Data

M.Wt:
212.68
Formula:
C10H12N2O.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
153-98-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A review of central 5-HT receptors and their function.
    Barnes and Sharp
    Neuropharmacology, 1999;38:1083

Product Datasheets

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Citations for Serotonin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:

12 Citations: Showing 1 - 10

  1. Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
    Authors: Szabo
    Sci Rep  2018;8(1):1765
  2. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  3. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
    Authors: Yin Et al.
    Cereb Cortex  2017;27:509
  4. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
    Authors: Hooper Et al.
    Am J Physiol Heart Circ Physiol  2016;311:H572
  5. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  6. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
    Authors: Haynes Et al.
    BMC Vet Res  2015;4
  7. Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  8. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
    Authors: Bracha Et al.
    Am J Physiol Regul Integr Comp Physiol  2013;9:251
  9. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience  2012;224:125
  10. Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
    Authors: Robery Et al.
    PLoS One  2011;6:e24439

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Reviews for Serotonin hydrochloride

Average Rating: 5 (Based on 1 Review)

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Works well and affordable
By Anonymous on 05/23/2019
Species: Mouse

Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.


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