Serotonin hydrochloride
Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Purity: ≥99%
Biological Activity
Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Background References
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A review of central 5-HT receptors and their function.
Barnes and Sharp
Neuropharmacology, 1999;38:1083
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Citations for Serotonin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
12 Citations: Showing 1 - 10
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Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
Authors: Szabo
Sci Rep 2018;8(1):1765
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Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
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Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
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Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Authors: Hooper Et al.
Am J Physiol Heart Circ Physiol 2016;311:H572
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Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
Neuropsychopharmacology 2015;40:3015
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A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
Authors: Haynes Et al.
BMC Vet Res 2015;4
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Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
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The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
Authors: Bracha Et al.
Am J Physiol Regul Integr Comp Physiol 2013;9:251
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Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Neuroscience 2012;224:125
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Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
Authors: Robery Et al.
PLoS One 2011;6:e24439
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5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Authors: Rawls Et al.
Neurosci Lett 2010;484:113
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Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Authors: Yang Et al.
Br J Pharmacol 2010;159:1623
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