Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Biological ActivityEndogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A review of central 5-HT receptors and their function.
Barnes and Sharp
Citations for Serotonin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
12 Citations: Showing 1 - 10
Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
Sci Rep 2018;8(1):1765
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Authors: Hooper Et al.
Am J Physiol Heart Circ Physiol 2016;311:H572
Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
Authors: Haynes Et al.
BMC Vet Res 2015;4
Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
Authors: Bracha Et al.
Am J Physiol Regul Integr Comp Physiol 2013;9:251
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
Authors: Robery Et al.
PLoS One 2011;6:e24439
5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Authors: Rawls Et al.
Neurosci Lett 2010;484:113
Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Authors: Yang Et al.
Br J Pharmacol 2010;159:1623
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Reviews for Serotonin hydrochloride
Average Rating: 5 (Based on 1 Review)
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Excellent product and affordable. Worked quite effectively for our ephys work, robustly hyperpolarizing neurons in control condition as expected.