Serotonin hydrochloride

Catalog # Availability Size / Price Qty
Serotonin hydrochloride | CAS No. 153-98-0 | Non-selective 5-HT Receptor Agonists
1 Image
Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine, 5-HT

Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride

Purity: ≥99%

Product Details
Citations (12)
Supplemental Products

Biological Activity

Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A review of central 5-HT receptors and their function.
    Barnes and Sharp
    Neuropharmacology, 1999;38:1083

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Serotonin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:

12 Citations: Showing 1 - 10

  1. Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
    Authors: Szabo
    Sci Rep  2018;8(1):1765
  2. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  3. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
    Authors: Yin Et al.
    Cereb Cortex  2017;27:509
  4. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
    Authors: Hooper Et al.
    Am J Physiol Heart Circ Physiol  2016;311:H572
  5. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  6. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
    Authors: Haynes Et al.
    BMC Vet Res  2015;4
  7. Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  8. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
    Authors: Bracha Et al.
    Am J Physiol Regul Integr Comp Physiol  2013;9:251
  9. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience  2012;224:125
  10. Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
    Authors: Robery Et al.
    PLoS One  2011;6:e24439


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Serotonin hydrochloride

There are currently no reviews for this product. Be the first to review Serotonin hydrochloride and earn rewards!

Have you used Serotonin hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.