Serotonin hydrochloride

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Serotonin hydrochloride | CAS No. 153-98-0 | Non-selective 5-HT Receptor Agonists
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Description: Endogenous 5-HT receptor agonist
Alternative Names: 5-Hydroxytryptamine,5-HT

Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride

Purity: ≥99%

Product Details
Citations (27)
Supplemental Products

Biological Activity

Serotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A review of central 5-HT receptors and their function.
    Barnes and Sharp
    Neuropharmacology, 1999;38:1083

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Citations for Serotonin hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:

27 Citations: Showing 1 - 10

  1. Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors.
    Authors: Bryan L Et al.
    Cell Rep  2022;40:111211
  2. Bimodal modulation of short-term motor memory via dynamic sodium pumps in a vertebrate spinal cord.
    Authors: Hongyan Et al.
    Curr Biol  2022;32:1038-1048.e2
  3. Co-packaging of opposing neurotransmitters in individual synaptic vesicles in the central nervous system.
    Authors: Bernardo L Et al.
    Neuron  2022;110:1371-1384.e7
  4. Gαi/o-coupled Htr2c in the paraventricular nucleus of the hypothalamus antagonizes the anorectic effect of serotonin agents.
    Authors: Lin Et al.
    Cell Rep  2021;37:109997
  5. Activation of PPG neurons following acute stressors differentially involves hindbrain serotonin in male rats.
    Authors: Heath D Et al.
    Neuropharmacology  2021;187:108477
  6. NACHO Engages N-Glycosylation ER Chaperone Pathways for α7 Nicotinic Receptor Assembly.
    Authors: David S Et al.
    Cell Rep  2020;32:108025
  7. The Serotonin Neurotransmitter Modulates Virulence of Enteric Pathogens.
    Authors: Sanjeev Et al.
    Cell Host Microbe  2020;28:41-53.e8
  8. Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex.
    Authors: Wieland B Et al.
    Neuron  2020;108:1113-1129.e6
  9. Hypophagia induced by hindbrain serotonin is mediated through central GLP-1 signaling and involves 5-HT2C and 5-HT3 receptor activation.
    Authors: Bart C Et al.
    Neuropsychopharmacology  2019;44:1742-1751
  10. A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila.
    Authors: Chang Et al.
    Curr Biol  2019;29:3635-3646.e5
  11. Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses.
    Authors: Thomas C Et al.
    Cell  2019;179:498-513.e22
  12. Differential serotonin transporter (5-HTT) and 5-HT2 receptor density in limbic and neocortical areas of adults and children with autism spectrum disorders: implications for selective serotonin reuptake inhibitor efficacy.
    Authors: Gene J Et al.
    J Neurochem  2019;151:642-655
  13. A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine.
    Authors: Hao Et al.
    Neuron  2019;102:745-761.e8
  14. Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
    Authors: Szabo
    Sci Rep  2018;8(1):1765
  15. Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells.
    Authors: Sean P Et al.
    Cancer Cell  2018;34:659-673.e6
  16. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  17. Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
    Authors: Yin Et al.
    Cereb Cortex  2017;27:509
  18. Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
    Authors: Hooper Et al.
    Am J Physiol Heart Circ Physiol  2016;311:H572
  19. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  20. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
    Authors: Haynes Et al.
    BMC Vet Res  2015;4
  21. Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
    Authors: Gerhold Et al.
    J Neurosci  2015;35:9580
  22. Spontaneous activity and stretch-induced contractile differentiation are reduced in vascular smooth muscle of miR-143/145 knockout mice.
    Authors: T Et al.
    Acta Physiol (Oxf)  2015;215:133-43
  23. The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
    Authors: Bracha Et al.
    Am J Physiol Regul Integr Comp Physiol  2013;9:251
  24. Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
    Authors: Daftary Et al.
    Neuroscience  2012;224:125
  25. Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
    Authors: Robery Et al.
    PLoS One  2011;6:e24439
  26. 5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
    Authors: Rawls Et al.
    Neurosci Lett  2010;484:113
  27. Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
    Authors: Yang Et al.
    Br J Pharmacol  2010;159:1623


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