Chemical Name: 3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride
Biological ActivitySerotonin hydrochloride is an endogenous agonist at 5-HT receptors and endogenous substrate for 5-HT transporters. Neurotransmitter that has roles in regulation of mood, emesis, sexuality, sleep and appetite in vivo. Caged serotonin is also available (Cat.No. 3991).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
A review of central 5-HT receptors and their function.
Barnes and Sharp
Citations for Serotonin hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for Serotonin hydrochloride include:
12 Citations: Showing 1 - 10
Immunomodulatory capacity of the serotonin receptor 5-HT2B in a subset of human dendritic cells.
Sci Rep 2018;8(1):1765
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
Selective Modulation of Axonal Sodium Channel Subtypes by 5-HT1A Receptor in Cortical Pyramidal Neuron.
Authors: Yin Et al.
Cereb Cortex 2017;27:509
Selective serotonin reuptake inhibitor exposure constricts the mouse ductus arteriosus in utero.
Authors: Hooper Et al.
Am J Physiol Heart Circ Physiol 2016;311:H572
Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
Authors: Bocchio Et al.
A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.
Authors: Haynes Et al.
BMC Vet Res 2015;4
Pronociceptive and antinociceptive effects of Bupren. in the spinal cord dorsal horn cover a dose range of four orders of magnitude.
Authors: Gerhold Et al.
J Neurosci 2015;35:9580
The expression and role of serotonin receptor 5HTR2A in canine osteoblasts and an osteosarcoma cell line.
Authors: Bracha Et al.
Am J Physiol Regul Integr Comp Physiol 2013;9:251
Essential role of brain-derived neurotrophic factor in the regulation of serotonin transmission in the basolateral amygdala.
Authors: Daftary Et al.
Investigating the effect of emetic compounds on chemotaxis in Dictyostelium identifies a non-sentient model for bitter and hot tastant research.
Authors: Robery Et al.
PLoS One 2011;6:e24439
5-HT1A-like receptor activation inhibits abstinence-induced metha. withdrawal in planarians.
Authors: Rawls Et al.
Neurosci Lett 2010;484:113
Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon.
Authors: Yang Et al.
Br J Pharmacol 2010;159:1623
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