Q: I would like to know if your Serpin A5/Protein C Inhibitor Antibody (2D10) is it the same antibody required for plasma serine protease inhibitor.

A: Our Serpin A5/Protein C Inhibitor antibody (2D10) with catalogue number NBP2-01833 was raised against full length recombinant human SERPINA5. SERPINA5 is also known as plasma serine protease inhibitor.

Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

Novus Biologicals | Catalog # NBP2-01833

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Product Specifications
Scientific Data
Applications
Flow Cytometry
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG₁ Clone # OTI2D10

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Product Specifications

Immunogen

Full length human recombinant protein of human SERPINA5(NP_000615) produced in HEK293T cell.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁

Theoretical MW

45.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

Western Blot: Serpin A5/Protein C Inhibitor Antibody (OTI2D10) [NBP2-01833]

Western Blot: Serpin A5/Protein C Inhibitor Antibody (2D10) [NBP2-01833] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY Protein C inhibitor (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-Protein C inhibitor.

Immunocytochemistry/ Immunofluorescence: Serpin A5/Protein C Inhibitor Antibody (OTI2D10) [NBP2-01833]

Immunocytochemistry/Immunofluorescence: Serpin A5/Protein C Inhibitor Antibody (OTI2D10) [NBP2-01833] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY Protein C inhibitor.

Immunohistochemistry-Paraffin: Serpin A5/Protein C Inhibitor Antibody (OTI2D10) [NBP2-01833]

Immunohistochemistry-Paraffin: Serpin A5/Protein C Inhibitor Antibody (2D10) [NBP2-01833] - Staining of paraffin-embedded Human tonsil using anti-Protein C inhibitor mouse monoclonal antibody.

Flow Cytometry: Serpin A5/Protein C Inhibitor Antibody (OTI2D10) [NBP2-01833]

Flow Cytometry: Serpin A5/Protein C Inhibitor Antibody (2D10) [NBP2-01833] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-Protein C inhibitor antibody, and then analyzed by flow cytometry.

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Applications for Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

Application

Recommended Usage

Flow Cytometry

1:100

Immunocytochemistry/ Immunofluorescence

1:100

Immunohistochemistry

1:150

Immunohistochemistry-Paraffin

1:150

Western Blot

1:2000

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Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

0.75 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Serpin A5/Protein C Inhibitor

PAI-1, PAI-2 and PAI-3 (plasminogen activator inhibitor-1, -2 and -3) are members of the serpin serine proteinase inhibitor family. PAI-1 and PAI-2 regulate uPA (urokinase-type plasminogen activator) and TPA (tissue plasminogen activator), resulting in the inhibition of proteolytic activity. Members of the serpin family generally complex with their target proteinases, then disassociate slowly into cleaved species that fold into stable inactive forms. PAI-1 can fold into the inactive state without cleavage resulting in the latent form of PAI-1. Activity can be restored to the latent form of PAI-1 through denaturation and renaturation. PAI-2 occurs in secreted and cytosolic forms through facultative polypeptide translocation. PAI-3 inhibits plasminogen activators as well as activated protein C. PAI-3 is secreted in plasma, but is also expressed in liver.

Alternate Names

PAI-3, PCI

Entrez Gene IDs

5104 (Human)

Gene Symbol

SERPINA5

Additional Serpin A5/Protein C Inhibitor Products

Product Documents for Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

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Certificate of Analysis

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Product Specific Notices for Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Coagulation

Serine Proteases and Regulators

Citations for Serpin A5/Protein C Inhibitor Antibody (OTI2D10)

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