Serum Amyloid A1 Antibody (CL9175) - BSA Free

Novus Biologicals | Catalog # NBP3-21169

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL9175

Format

BSA Free
View all Serum Amyloid A1 Primary Antibodies »

Product Specifications

Immunogen

This antibody was developed using a synthetic peptide derived from P0DJI8, with the exact immunogen sequence remaining proprietary.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Serum Amyloid A1 Antibody (CL9175) - BSA Free

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Staining of human endometrium shows no positivity in glandular cells as expected.
Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Staining of human colon shows strong positivity in plasma.
Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Staining of human liver shows weak to moderate cytoplasmic positivity in hepatocytes.
Western Blot: Serum Amyloid A1 Antibody [NBP3-21169] -

Western Blot: Serum Amyloid A1 Antibody [NBP3-21169] -

Analysis in human liver tissue.
Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Immunohistochemistry-Paraffin: Serum Amyloid A1 Antibody [NBP3-21169] -

Staining of human pancreas shows strong positivity in plasma.

Applications for Serum Amyloid A1 Antibody (CL9175) - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000

Western Blot

1 ug/ml
Application Notes
IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Serum Amyloid A1

The serum amyloid A (SAA) family comprises a number of differentially expressed lipoproteins, acute phase SAA1 and SAA2, the former being a major component in plasma, and constitutive SAA's (C-SAAs). Although the liver is the primary site of synthesis of both SAA types, extrhepatic production has been reported. The in vivo concentrations increase by as much as 1000 fold during inflammation. Several studies have expressed its importance in the diagnosis and monitoring of various diseases. Pathological SAA values are often detected in association with normal CRP concentrations. SAA rises earlier and more sharply than CRP. SAA enhances the binding of HDL's to macrophages and thus helps the delivery of lipid to sites of injury for use in tissue repair. It is thus thought to be an integral part of the disease process. In addition, recent experiments suggest that SAA may play a quot houekeeping quot role in normal human tissues. Elevated levels of SAA over time predispose secondary amyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulating precursor, in various tissues and organs. The most common form of amyloidosis occurs secondary to chronic inflammatory disease, particularly rheumatoid artheritis. Amyloidosis is a heterogeneous group of disorders characterized by extracellular deposition of abnormal protein fibrils, which are derived from different proteins. Almost all patients with amyloidosis have some level of renal disorders. The immunoperoxidase technique has the advantage of being able to detect amyloid in formalin-fixed paraffin embedded tissues and is a very specific method for identifying amyloid fibril proteins. Small and minute amounts of amyloid can be detected with both Amyloid P (ab688) and Amyloid A antibodies, and thus could allow earlier treatment before organ damage has occurred.

Alternate Names

PIG4, SAA1

Gene Symbol

SAA1

Additional Serum Amyloid A1 Products

Product Documents for Serum Amyloid A1 Antibody (CL9175) - BSA Free

Certificate of Analysis

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Product Specific Notices for Serum Amyloid A1 Antibody (CL9175) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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