Signal peptide peptidase-like 2B Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-59510

Novus Biologicals
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Signal peptide peptidase-like 2B Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to SPPL2B(signal peptide peptidase-like 2B) The peptide sequence was selected from the N terminal of SPPL2B. Peptide sequence VARGNCTFYEKVRLAQGSGARGLLIVSRERLVPPGGNKTQYDEIGIPVAL. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Signal peptide peptidase-like 2B Antibody - BSA Free

Western Blot: Signal peptide peptidase-like 2B Antibody [NBP1-59510]

Western Blot: Signal peptide peptidase-like 2B Antibody [NBP1-59510]

Western Blot: Signal peptide peptidase-like 2B Antibody [NBP1-59510] - Jurkat cell lysate, concentration 1 ug/ml.
Immunohistochemistry-Paraffin: Signal peptide peptidase-like 2B Antibody [NBP1-59510]

Immunohistochemistry-Paraffin: Signal peptide peptidase-like 2B Antibody [NBP1-59510]

Immunohistochemistry-Paraffin: Signal peptide peptidase-like 2B Antibody [NBP1-59510] - Human kidney Tissue, antibody concentration 4-8ug/ml. Cells with positive label: renal corpuscle cells (indicated with arrows) 400X magnification.

Applications for Signal peptide peptidase-like 2B Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Signal peptide peptidase-like 2B

SPPL2B is a member of the GXGD family of aspartic proteases. The GXGD proteases are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions. This enzyme localizes to endosomes, lysosomes, and the plasma membrane. It cleaves the transmembrane domain of tumor necrosis factor alpha to release the intracellular domain, which triggers cytokine expression in the innate and adaptive immunity pathways.

Alternate Names

EC 3.4.23, EC 3.4.23.-, IMP-4, IMP4MGC111084, Intramembrane protease 4, KIAA1532signal peptide peptidase-like 2B, Presenilin-like protein 1, PSL1, SNPPL2B, SPPL2b, SPP-like 2B

Gene Symbol

SPPL2B

UniProt

Q8TCT7-4 (Human)

Additional Signal peptide peptidase-like 2B Products

Product Documents for Signal peptide peptidase-like 2B Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Signal peptide peptidase-like 2B Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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