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SK1-I

Catalog #: 3711 Datasheet / COA / SDS

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3711 has been discontinued.
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SK1-I | CAS No. 1072443-89-0 | Sphingosine Kinase Inhibitors
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Description: Sphingosine kinase 1 (SphK1) inhibitor; antiproliferative

Chemical Name: 1,2,4-Trideoxy-4-(methylamino)-1-(4-pentylphenyl)-D-erythro-pent-1-enitol hydrochloride

Purity: ≥98%

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Biological Activity

Sphingosine kinase (SphK) inhibitor. Isoenzyme-selective for SphK1; displays no activity at SphK2. Also displays no inhibitory activity against a range of protein kinases including PKC, PKA, ERK1, EGFR and CDK2. Exhibits potent antileukemic activity in vivo; inhibits the growth of both U937 and Jurkat T cells. Also suppresses proliferation and induces apoptosis in several human glioblastoma cell lines.

Technical Data

M.Wt:
313.86
Formula:
C17H27NO2.HCl
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1072443-89-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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