SKF 81297 hydrobromide

Catalog # Availability Size / Price Qty

SAVE +FREE SHIPPING with ACADEMIA23 (See Promo Details)

SKF 81297 hydrobromide | CAS No. 67287-39-2 | Dopamine D1 and D5 Receptor Agonists
1 Image
Description: D1 agonist

Chemical Name: (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide

Purity: ≥98%

Product Details
Citations (25)
Supplemental Products

Biological Activity

SKF 81297 hydrobromide is a dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 10 mM in water with gentle warming
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for SKF 81297 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 81297 hydrobromide include:

25 Citations: Showing 1 - 10

  1. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
    Authors: Dorst Et al.
    Nat Commun  2020;11:5113
  2. Functional roles of ST8SIA3-mediated sialylation of striatal DA D2 and adenosine A2A receptors.
    Authors: Lin Et al.
    Transl Psychiatry  2019;9:209
  3. Chemokine CXCL1 is responsible for cocaine-induced reward in mice.
    Authors: Saika
    NeurosciPharm Reports  2018;38(3):145
  4. A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
    Authors: Liu Et al.
    Neuron  2017;95:817
  5. Distinct retinoic acid receptor (RAR) isotypes control differentiation of embryonal carcinoma cells to dopaminergic or striatopallidal medium spiny neurons.
    Authors: Podleśny-Drabiniok Et al.
    Sci Rep  2017;7:13671
  6. DA D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell  2017;16(6):1323
  7. The First Alcohol Drink Triggers mTORC1-Dependent Synaptic Plasticity in Nucleus Accumbens DA D1 Receptor Neurons.
    Authors: Beckley Et al.
    J Neurosci  2016;36:701
  8. DArgic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
    Authors: Pezze Et al.
    Mol Med Rep  2015;232:2669
  9. Effect of DArgic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
    Authors: Meunier Et al.
    PLoS One  2015;10:e0120286
  10. PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.
    Authors: Spulber Et al.
    PLoS One  2014;9:e94227
  11. Glucocorticoid receptor gene inactivation in DA-innervated areas selectively decreases behavioral responses to amphetamine.
    Authors: Parnaudeau Et al.
    Front Behav Neurosci  2014;8:35
  12. Differential role of D1 and D2 receptors in the perifornical lateral hypothalamus in controlling ethanol drinking and food intake: possible interaction with local orexin neurons.
    Authors: Chen Et al.
    Alcohol Clin Exp Res  2014;38:777
  13. DArgic modulation of GABAergic transmission in the entorhinal cortex: concerted roles of α1 adrenoreceptors, inward rectifier K+, and T-type Ca2+ channels.
    Authors: Cilz Et al.
    Cereb Cortex  2014;24:3195
  14. DA signaling leads to loss of Polycomb repression and aberrant gene activation in experimental parkinsonism.
    Authors: Södersten Et al.
    PLoS Genet  2014;10:e1004574
  15. GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.
    Authors: Marley Et al.
    Psychopharmacology (Berl)  2013;8:e70857
  16. Coincidence signaling of DA D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex.
    Authors: Olianas Et al.
    Neurosignals  2012;21:61
  17. DArgic modulation of the hippocampal neuropil proteome identified by bioorthogonal noncanonical amino acid tagging (BONCAT).
    Authors: Hodas Et al.
    Proteomics  2012;12:2464
  18. Stimulation of the D5 DA receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
    Authors: Guha Et al.
    J Neurochem  2012;122:823
  19. CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
    Authors: Urizar Et al.
    Nat Neurosci  2011;7:624
  20. DA-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala.
    Authors: Krishnan Et al.
    PLoS One  2011;6:e25639
  21. Casein kinase 1 enables nucleus accumbens amphetamine-induced locomotion by regulating AMPA receptor phosphorylation.
    Authors: Li Et al.
    J Neurochem  2011;118:237
  22. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    PLoS One  2010;13:1128
  23. D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
    Authors: Stramiello
    Neuropharmacology  2008;55:871
  24. D1-like DA receptor activation modulates GABAergic inhibition but not electrical coupling between neocortical fast-spiking interneurons.
    Authors: Towers and Hestrin
    J Neurosci  2008;28:2633
  25. DArgic regulation of inhibitory and excitatory transmission in the basolateral amygdala-prefrontal cortical pathway.
    Authors: Floresco and Tse
    J Neurosci  2007;27:2045


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

VersaClone cDNA Plasmids

Reviews for SKF 81297 hydrobromide

There are currently no reviews for this product. Be the first to review SKF 81297 hydrobromide and earn rewards!

Have you used SKF 81297 hydrobromide?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.