Catalog Number: 1447
Chemical Name: (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide
Biological Activity
Dopamine D1-like receptor agonist. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    370.67
  • Formula:
    C16H16ClNO2.HBr
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in water
  • Purity:
    >98%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    67287-39-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Relative dopamine D1 and D2 receptor affinity and efficacy determine whether dopamine agonists induce hyperactivity or oral stereotypy in rats.
    Arnt et al.
    Pharmacol.Toxicol., 1988;62:121
  2. Pharmacological characterization of the discriminative stimulus properties of the dopamine D1 agonist, SKF 81297.
    Reavill et al.
    Behav.Pharmacol., 1993;4:135
  3. The effects of dopamine D1 and D2 receptor agonists and antagonists in monkeys withdrawn from long-term neuroleptic treatment.
    Peacock et al.
    Eur.J.Pharmacol., 1990;186:49
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 81297 hydrobromide include:

9 Citations: Showing 1 - 9
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  1. Dopamine D4 receptor activation restores CA1 LTP in hippocampal slices from aged mice.
    Authors: Guo
    Aging Cell 2017;16(6):1323
  2. Dopaminergic modulation of appetitive trace conditioning: the role of D1 receptors in medial prefrontal cortex.
    Authors: Pezze Et al.
    Mol Med Rep 2015;232:2669
  3. Effect of dopaminergic D1 receptors on plasticity is dependent of serotoninergic 5-HT1A receptors in L5-pyramidal neurons of the prefrontal cortex.
    Authors: Meunier Et al.
    PLoS One 2015;10:e0120286
  4. Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine.
    Authors: Parnaudeau Et al.
    Front Behav Neurosci 2014;8:35
  5. GPR88 reveals a discrete function of primary cilia as selective insulators of GPCR cross-talk.
    Authors: Marley Et al.
    Psychopharmacology (Berl) 2013;8:e70857
  6. Coincidence signaling of dopamine D1-like and M1 muscarinic receptors in the regulation of cyclic AMP formation and CREB phosphorylation in mouse prefrontal cortex.
    Authors: Olianas Et al.
    Neurosignals 2012;21:61
  7. Stimulation of the D5 dopamine receptor acidifies the lysosomal pH of retinal pigmented epithelial cells and decreases accumulation of autofluorescent photoreceptor debris.
    Authors: Guha Et al.
    J Neurochem 2012;122:823
  8. CODA-RET reveals functional selectivity as a result of GPCR heteromerization.
    Authors: Urizar Et al.
    Nat Neurosci 2011;7:624
  9. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    PLoS One 2010;13:1128

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