SKF 83566 hydrobromide

  ( 7 citations )    
Product Datasheet
Catalog Number:1586
Chemical Name:8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
Product Details
Citations (7)
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Biological Activity
Potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    413.15
  • Formula:
    C17H18BrNO.HBr
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at RT
  • CAS No:
    108179-91-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:

7 Citations: Showing 1 - 7
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  1. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Hum Mol Genet  2015;9:310
  2. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    Learn Mem  2015;24:197
  3. Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
    Authors: Savalli Et al.
    J Neurosci  2015;22:69
  4. D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus.
    Authors: Huang Et al.
    Learn Mem  2014;21:153
  5. Dopamine receptors in human embryonic stem cell neurodifferentiation.
    Authors: Belinsky Et al.
    Stem Cells Dev  2013;22:1522
  6. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism.
    Authors: Billes Et al.
    Mol Metab  2012;1:86
  7. Increased dopamine level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    World J Gastroenterol  2008;28:5539

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