SKF 83566 hydrobromide

Tocris Bioscience | Catalog # 1586

Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2
Tocris Bioscience

Key Product Details

Description

Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2
View all Dopamine D1 and D5 Receptor Antagonists »

Product Description

SKF 83566 hydrobromide is a potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Product Specifications for SKF 83566 hydrobromide

Molecular Weight

413.15

Formula

C17H18BrNO.HBr

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

CAS Number

108179-91-5

PubChem ID

23581817

InChI Key

SDQJYYGODYRPBR-UHFFFAOYSA-N

SMILES

Br.CN1CCC2=CC(Br)=C(O)C=C2C(C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.31 100

Preparing Stock Solutions for SKF 83566 hydrobromide

The following data is based on the product molecular weight 413.15.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.42 mL 12.10 mL 24.20 mL
5 mM 0.48 mL 2.42 mL 4.84 mL
10 mM 0.24 mL 1.21 mL 2.42 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

Product Documents for SKF 83566 hydrobromide

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKF 83566 hydrobromide

For research use only

Citations for SKF 83566 hydrobromide

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