Potent and selective D1
-like dopamine receptor antagonist (Ki
~ 0.56 nM for D1
= 2 μ
M for D2
). Also antagonist at the vascular 5-HT2
= 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo
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All Tocris products are intended for laboratory research use only.
Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.
Fritts et al.
Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats.
Meyer et al.
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.
Conley et al.
SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors.
Ohlstein and Berkowitz
The citations listed below are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:
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