SKF 83566 hydrobromide
Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
Biological ActivitySKF 83566 hydrobromide is a potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.
Conley et al.
SCH 23390 and SK&F 83566 are antagonists at vascular DA and serotonin receptors.
Ohlstein and Berkowitz
Effects of DA D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats.
Meyer et al.
Locomotor stereotypy produced by dexbenzetimide and scopol. is reduced by SKF 83566, not sulpiride.
Fritts et al.
Citations for SKF 83566 hydrobromide
The citations listed below are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:
10 Citations: Showing 1 - 10
DA-dependent effects on basal and glutamate stimulated network dynamics in cultured hippocampal neurons.
Authors: Li Et al.
J Neurochem 2017;140:550
Activation of DRD5 inhibits tumor growth by autophagic cell death.
Authors: Leng Et al.
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Authors: Xing Et al.
Hum Mol Genet 2015;9:310
A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila.
Authors: Cassar Et al.
Learn Mem 2015;24:197
Regionally selective requirement for D1/D5 DArgic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
Authors: Savalli Et al.
J Neurosci 2015;22:69
D1/D5 receptors and histone deacetylation mediate the Gateway Effect of LTP in hippocampal dentate gyrus.
Authors: Huang Et al.
Learn Mem 2014;21:153
DA receptors in human embryonic stem cell neurodifferentiation.
Authors: Belinsky Et al.
Stem Cells Dev 2013;22:1522
Leptin reduces food intake via a DA D2 receptor-dependent mechanism.
Authors: Billes Et al.
Mol Metab 2012;1:86
D1/5 receptor-mediated enhancement of LTP requires PKA, Src family kinases, and NR2B-containing NMDARs.
Increased DA level enhances male-male courtship in Drosophila.
Authors: Liu Et al.
World J Gastroenterol 2008;28:5539
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