SKF 83566 hydrobromide

Catalog # Availability Size / Price Qty
1586/10
1586/50
SKF 83566 hydrobromide | CAS No. 108179-91-5 | Dopamine D1 and D5 Receptor Antagonists
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Description: Potent and selective D1-like antagonist; also inhibits adenylyl cyclase 2

Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide

Purity: ≥98%

Product Details
Citations (10)
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Biological Activity

SKF 83566 hydrobromide is a potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.

Technical Data

M.Wt:
413.15
Formula:
C17H18BrNO.HBr
Solubility:
Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
108179-91-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SKF 83566 hydrobromide

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