Catalog Number: 1586
Chemical Name: 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide
Biological Activity
Potent and selective D1-like dopamine receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). Also antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Displays selective inhibition of adenylyl cyclase 2 (AC2); inactive against AC1 or AC5. Centrally active following systemic administration in vivo.
Technical Data
  • M.Wt:
    413.15
  • Formula:
    C17H18BrNO.HBr
  • Solubility:
    Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    108179-91-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.
    Fritts et al.
    Pharmacol.Biochem.Behav., 1998;60:639
  2. Effects of dopamine D1 antagonists SCH23390 and SK&F83566 on locomotor activities in rats.
    Meyer et al.
    Pharmacol.Biochem.Behav., 1993;44:429
  3. Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.
    Conley et al.
    J.Pharmacol.Exp.Ther., 2013;347:276
  4. SCH 23390 and SK&F 83566 are antagonists at vascular dopamine and serotonin receptors.
    Ohlstein and Berkowitz
    Eur.J.Pharmacol., 1985;108:205
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 83566 hydrobromide include:

6 Citations: Showing 1 - 6
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  1. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Hum Mol Genet 2015;9:310
  2. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    Learn Mem 2015;24:197
  3. Regionally selective requirement for D1/D5 dopaminergic neurotransmission in the medial prefrontal cortex in object-in-place associative recognition memory.
    Authors: Savalli Et al.
    J Neurosci 2015;22:69
  4. Dopamine receptors in human embryonic stem cell neurodifferentiation.
    Authors: Belinsky Et al.
    Stem Cells Dev 2013;22:1522
  5. Leptin reduces food intake via a dopamine D2 receptor-dependent mechanism.
    Authors: Billes Et al.
    Mol Metab 2012;1:86
  6. Increased dopamine level enhances male-male courtship in Drosophila.
    Authors: Liu Et al.
    World J Gastroenterol 2008;28:5539

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