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SKF 83959 hydrobromide

Catalog #: 2074
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2074/10
2074/50
SKF 83959 hydrobromide | CAS No. 67287-95-0 | Dopamine D1 and D5 Receptor Agonists
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Description: D1-like partial agonist

Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol

Purity: ≥98%

Product Details
Citations (6)
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Biological Activity

SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.

Technical Data

M.Wt:
398.73
Formula:
C18H20ClNO2.HBr
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
67287-95-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SKF 83959 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 83959 hydrobromide include:

6 Citations: Showing 1 - 6

  1. Regulation of c-fos expression by the DA D1-D2 receptor heteromer.
    Authors: Perreault Et al.
    Neuroscience  2015;285:194
  2. A DA receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    Pharmacol Biochem Behav  2015;24:197
  3. The DA D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization.
    Authors: Shen Et al.
    Br J Pharmacol  2015;128:33
  4. DA D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
    Authors: Fuenzalida Et al.
    PLoS One  2014;171:5650
  5. A physiological role for the DA D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.
    Authors: Perreault Et al.
    Int J Neuropsychopharmacol  2013;16:477
  6. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    Authors: Huang Et al.
    Nat Chem Biol  2012;7:e49954

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VersaClone cDNA Plasmids

Human Dopamine D1R/DRD1 (NP_000785) VersaClone cDNA

RDC0379

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