Catalog Number: 2074
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol
Biological Activity
Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?
    Cools et al.
    Neuropharmacology, 2002;42:237
  2. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.
    Neumeyer et al.
    Eur.J.Pharmacol., 2003;474:137
  3. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.
    Platt et al.
    J.Pharmacol.Exp.Ther., 2000;293:1017
  4. SKF83959 is a potent allosteric modulator of sigma-1 receptor.
    Guo et al.
    Mol.Pharmacol., 2013;83:577
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