SKF 83959 hydrobromide

Key Product Details

Product Description

SKF 83959 hydrobromide is a dopamine D₁-like receptor partial agonist (K_i values are 1.18, 7.56, 920 and 399 nM for rat D₁, D₅, D₂ and D₃ receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ₁ receptor.

Product Specifications for SKF 83959 hydrobromide

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SKF 83959 hydrobromide

The following data is based on the product molecular weight 398.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.02 mL	25.08 mL	50.16 mL
2.5 mM	1.00 mL	5.02 mL	10.03 mL
5 mM	0.50 mL	2.51 mL	5.02 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 17 publications citing the usage of this product.

• Guo SKF83959 is a potent allosteric modulator of sigma-1 receptor. Mol.Pharmacol. 2013 PMID: 23295385
• Cools SKF 83959 is an antagonist of DA D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals? Neuropharmacology 2002 PMID: 11804620
• Neumeyer Receptor affinities of DA D1 receptor-selective novel phenylbenzazepines. Eur.J.Pharmacol. 2003 PMID: 12921854
• Platt Dissociation of cocaine-antagonist properties and motoric effects of the D₁ receptor partial agonists SKF 83959 and SKF 77434. J.Pharmacol.Exp.Ther. 2000 PMID: 10869406

Product Documents for SKF 83959 hydrobromide