Catalog Number: 2074
Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol
Biological Activity
Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the σ1 receptor.
Technical Data
  • M.Wt:
    398.73
  • Formula:
    C18H20ClNO2.HBr
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at RT
  • CAS No:
    67287-95-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. SKF 83959 is an antagonist of dopamine D1-like receptors in the prefrontal cortex and nucleus accumbens: a key to its antiparkinsonian effect in animals?
    Cools et al.
    Neuropharmacology, 2002;42:237
  2. Receptor affinities of dopamine D1 receptor-selective novel phenylbenzazepines.
    Neumeyer et al.
    Eur.J.Pharmacol., 2003;474:137
  3. Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434.
    Platt et al.
    J.Pharmacol.Exp.Ther., 2000;293:1017
  4. SKF83959 is a potent allosteric modulator of sigma-1 receptor.
    Guo et al.
    Mol.Pharmacol., 2013;83:577
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SKF 83959 hydrobromide include:

5 Citations: Showing 1 - 5
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  1. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila.
    Authors: Cassar Et al.
    Pharmacol Biochem Behav 2015;24:197
  2. The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization.
    Authors: Shen Et al.
    Br J Pharmacol 2015;128:33
  3. Dopamine D1 and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells.
    Authors: Fuenzalida Et al.
    PLoS One 2014;171:5650
  4. A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex.
    Authors: Perreault Et al.
    Int J Neuropsychopharmacol 2013;16:477
  5. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes.
    Authors: Huang Et al.
    Nat Chem Biol 2012;7:e49954

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