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SKI 178

Catalog #: 5452 Datasheet / COA / SDS

Discontinued Product

5452 has been discontinued.
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SKI 178 | CAS No. 1259484-97-3 | Sphingosine Kinase Inhibitors
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Description: Non-lipid sphingosine kinase 1 (SphK1) inhibitor

Chemical Name: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide

Purity: ≥98%

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Biological Activity

Non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). Induces CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Active in vivo.

Technical Data

M.Wt:
394.42
Formula:
C21H22N4O4
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1259484-97-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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