Selective inhibitor of MEK1 and MEK2 (IC50
values are 0.18 and 0.22 μ
M respectively); blocks hippocampal LTP in vitro
. Brain penetrant in vivo
, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
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All Tocris products are intended for laboratory research use only.
Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
Menge et al.
J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.
Davis et al.
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
Scherle et al.
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
Wang et al.
The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:
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