SL 327

Catalog # Availability Size / Price Qty
1969/10
1969/1
1969/50
Cat.No. 1969 - SL 327 | C16H12F3N3S | CAS No. 305350-87-2
1 Image
Description: Selective inhibitor of MEK1 and MEK2; brain penetrant

Chemical Name: α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

Purity: ≥99%

Product Details
Citations (17)
Reviews

Biological Activity

Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Technical Data

M.Wt:
335.35
Formula:
C16H12F3N3S
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at +4°C
CAS No:
305350-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Microwave-assisted synthesis of KN-93, a potent and selective inhibitor or Ca2+/Calmoduline-dependent protein kinase II.
    Bruno et al.
    Synthesis, 2010;24:4193
  2. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.
    Davis et al.
    J.Neurosci., 2000;20:4563
  3. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
    Scherle et al.
    J.Biol.Chem., 2000;275:37086
  4. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
    Wang et al.
    J.Pharmacol.Exp.Ther., 2003;304:172
  5. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  6. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  7. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  8. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  9. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  10. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  11. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  12. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  13. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  14. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  15. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602
  16. The MAPK cascade is required for mammalian associative learning.
    Atkins et al.
    Nature Neurosci., 1998;1:602

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Citations for SL 327

The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:

17 Citations: Showing 1 - 10

  1. Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
    Authors: Rhim Et al.
    Scientific Reports  2016;6:26547
  2. Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
    Authors: Urs Et al.
    J Biol Chem  2015;112:E2517
  3. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  4. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442
  5. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
    Authors: Lee Et al.
    Nat Neurosci  2014;17:1736
  6. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.
    Authors: Seese Et al.
    Proc Natl Acad Sci U S A  2014;111:16907
  7. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  8. A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.
    Authors: Urs Et al.
    Neuropsychopharmacology  2011;36:551
  9. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
    Authors: Subramanian and Morozov
    J Neurosci  2011;31:4755
  10. A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.
    Authors: Freeman Et al.
    Cancer Biol Ther  2011;12:966

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