SL 327

  ( 17 citations )    
Product Datasheet
Catalog Number:1969
Chemical Name:α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Product Details
Citations (17)
Biological Activity
Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:

17 Citations: Showing 1 - 10
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  1. Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
    Authors: Rhim Et al.
    Scientific Reports  2016;6:26547
  2. Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
    Authors: Urs Et al.
    J Biol Chem  2015;112:E2517
  3. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  4. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442
  5. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
    Authors: Lee Et al.
    Nat Neurosci  2014;17:1736
  6. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.
    Authors: Seese Et al.
    Proc Natl Acad Sci U S A  2014;111:16907
  7. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  8. A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.
    Authors: Urs Et al.
    Neuropsychopharmacology  2011;36:551
  9. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
    Authors: Subramanian and Morozov
    J Neurosci  2011;31:4755
  10. A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.
    Authors: Freeman Et al.
    Cancer Biol Ther  2011;12:966
  11. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.
    Authors: Osterweil Et al.
    J Neurosci  2010;30:15616
  12. Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.
    Authors: Alter Et al.
    J Neurosci  2010;30:11537
  13. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway.
    Authors: Chen-Roetling Et al.
    Neuropharmacology  2009;56:922
  14. Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.
    Authors: Faccidomo Et al.
    Psychopharmacology (Berl)  2009;204:135
  15. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Proc Natl Acad Sci U S A  2007;32:399
  16. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
    Authors: Beaulieu Et al.
    Neuropsychopharmacology  2006;281:32072
  17. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
    Authors: Beaulieu Et al.
    Cell  2005;122:261
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