Chemical Name: α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Biological ActivitySL 327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Olanzapine: preclinical and clinical profiles of a novel antipsychotic agent.
Tollefson and Taylor
CNS Drug Reviews, 2000;6:303
The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.
Davis et al.
Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
Scherle et al.
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
Wang et al.
The MAPK cascade is required for mammalian associative learning.
Atkins et al.
Nature Neurosci., 1998;1:602
Citations for SL 327
The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:
20 Citations: Showing 1 - 10
The Protective Effect of Ins. on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities.
Authors: Zakharova Et al.
Int J Mol Sci 2019;20
Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stress.
Authors: Oh Et al.
Mol Med Rep 2017;15:2583
Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
Authors: Rhim Et al.
Scientific Reports 2016;6:26547
Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes.
Authors: Liddell Et al.
J Neuroinflammation 2016;13:49
Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
Authors: Urs Et al.
J Biol Chem 2015;112:E2517
mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
Authors: Kubota Et al.
PLoS One 2014;9:e106316
G Protein and β-arrestin signaling bias at the ghrelin receptor.
Authors: Evron Et al.
J Biol Chem 2014;289:33442
Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
Authors: Lee Et al.
Nat Neurosci 2014;17:1736
Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.
Authors: Seese Et al.
Proc Natl Acad Sci U S A 2014;111:16907
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Authors: Keasey Et al.
Cell Commun Signal 2013;11:35
A DA D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.
Authors: Urs Et al.
Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
Authors: Subramanian and Morozov
J Neurosci 2011;31:4755
A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.
Authors: Freeman Et al.
Cancer Biol Ther 2011;12:966
Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.
Authors: Osterweil Et al.
J Neurosci 2010;30:15616
Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.
Authors: Alter Et al.
J Neurosci 2010;30:11537
Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway.
Authors: Chen-Roetling Et al.
Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.
Authors: Faccidomo Et al.
Psychopharmacology (Berl) 2009;204:135
Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
Authors: García-Fuster Et al.
Proc Natl Acad Sci U S A 2007;32:399
Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
Authors: Beaulieu Et al.
An Akt/beta-arrestin 2/PP2A signaling complex mediates DArgic neurotransmission and behavior.
Authors: Beaulieu Et al.
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