Catalog Number: 1969
Chemical Name: α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Biological Activity
Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Technical Data
  • M.Wt:
    335.35
  • Formula:
    C16H12F3N3S
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Desiccate at +4°C
  • CAS No:
    305350-87-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites.
    Menge et al.
    J.Labelled Comp.Radiopharm. XXXI, 1992;10:781
  2. The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo.
    Davis et al.
    J.Neurosci., 2000;20:4563
  3. Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy.
    Scherle et al.
    J.Biol.Chem., 2000;275:37086
  4. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
    Wang et al.
    J.Pharmacol.Exp.Ther., 2003;304:172
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:

9 Citations: Showing 1 - 9
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  1. Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
    Authors: Rhim Et al.
    Scientific Reports 2016;6:26547
  2. Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
    Authors: Urs Et al.
    J Biol Chem 2015;112:E2517
  3. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One 2014;9:e106316
  4. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal 2013;11:35
  5. A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.
    Authors: Urs Et al.
    Neuropsychopharmacology 2011;36:551
  6. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
    Authors: Subramanian and Morozov
    J Neurosci 2011;31:4755
  7. A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.
    Authors: Freeman Et al.
    Cancer Biol Ther 2011;12:966
  8. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Proc Natl Acad Sci U S A 2007;32:399
  9. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
    Authors: Beaulieu Et al.
    Neuropsychopharmacology 2006;281:32072

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