SL 327

  ( 17 citations )    
Product Datasheet
Catalog Number:1969
Chemical Name:α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
Product Details
Citations (17)
Reviews
Biological Activity
Selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
Technical Data
  • M.Wt:
    335.35
  • Formula:
    C16H12F3N3S
  • Solubility:
    Soluble to 50 mM in ethanol and to 100 mM in DMSO
  • Purity:
    >99
  • Storage:
    Desiccate at +4°C
  • CAS No:
    305350-87-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
COA view current batch
or select another batch:
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SL 327 include:

17 Citations: Showing 1 - 10
Filter your results:

  1. Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells
    Authors: Rhim Et al.
    Scientific Reports  2016;6:26547
  2. Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.
    Authors: Urs Et al.
    J Biol Chem  2015;112:E2517
  3. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  4. G Protein and β-arrestin signaling bias at the ghrelin receptor.
    Authors: Evron Et al.
    J Biol Chem  2014;289:33442
  5. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
    Authors: Lee Et al.
    Nat Neurosci  2014;17:1736
  6. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice.
    Authors: Seese Et al.
    Proc Natl Acad Sci U S A  2014;111:16907
  7. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  8. A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.
    Authors: Urs Et al.
    Neuropsychopharmacology  2011;36:551
  9. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
    Authors: Subramanian and Morozov
    J Neurosci  2011;31:4755
  10. A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death.
    Authors: Freeman Et al.
    Cancer Biol Ther  2011;12:966
  11. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome.
    Authors: Osterweil Et al.
    J Neurosci  2010;30:15616
  12. Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models.
    Authors: Alter Et al.
    J Neurosci  2010;30:11537
  13. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway.
    Authors: Chen-Roetling Et al.
    Neuropharmacology  2009;56:922
  14. Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.
    Authors: Faccidomo Et al.
    Psychopharmacology (Berl)  2009;204:135
  15. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway.
    Authors: García-Fuster Et al.
    Proc Natl Acad Sci U S A  2007;32:399
  16. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.
    Authors: Beaulieu Et al.
    Neuropsychopharmacology  2006;281:32072
  17. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
    Authors: Beaulieu Et al.
    Cell  2005;122:261
Expand to show all Citations

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Have you used SL 327?

Submit a review and receive a $25US/€18/£15/$25CAN amazon gift card if you include an image - $10US/€7/£6/$10CAN Amazon card for reviews without an image. Limited to verified customers in USA, Canada and Europe.

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

Order Details

Contact Us to Order
reload

Feedback

Customer Information
Calculators

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

R&D Systems Guarantee