SMIFH2 (CAS 340316-62-3): R&D Systems
Catalog Number: 4401
Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Biological Activity
Inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
Technical Data
  • M.Wt:
    377.21
  • Formula:
    C15H9BrN2O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >99%
  • Storage:
    Store at +4°C
  • CAS No:
    340316-62-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
    Rizvi et al.
    Chem.Biol., 2009;16:1158
  2. Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.
    Poincloux et al.
    Proc.Natl.Acad.Sci.USA, 2011;108:1943
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SMIFH2 include:

1 Citations: Showing 1 - 1

  1. ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
    Authors: Tornavaca Et al.
    J Neurosci 2015;208:821

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