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SMIFH2

Catalog #: 4401
12 Citations Datasheet / COA / SDS

Discontinued Product

4401 has been discontinued.
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SMIFH2 | CAS No. 340316-62-3 | Actin-related Products
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Description: FH2 domain inhibitor; prevents actin nucleation

Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

Purity: ≥99%

Product Details
Citations (12)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SMIFH2 is an inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.

Technical Data

M.Wt:
377.21
Formula:
C15H9BrN2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
340316-62-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SMIFH2

The citations listed below are publications that use Tocris products. Selected citations for SMIFH2 include:

12 Citations: Showing 1 - 10

  1. Nuclear F-actin and Lamin A antagonistically modulate nuclear shape.
    Authors: Daniel L Et al.
    J Cell Sci  2022;135
  2. Protein diaphanous homolog 1 (Diaph1) promotes myofibroblastic activation of hepatic stellate cells by regulating Rab5a activity and TGFβ receptor endocytosis.
    Authors: Xinhui Et al.
    FASEB J  2020;34:7345-7359
  3. Macropinocytosis Overcomes Directional Bias in Dendritic Cells Due to Hydraulic Resistance and Facilitates Space Exploration.
    Authors: Matthieu Et al.
    Dev Cell  2019;49:171-188.e5
  4. Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.
    Authors: Alieva Et al.
    Nat Commun  2019;10:3593
  5. Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish.
    Authors: LeCorgne Et al.
    Front Pharmacol  2018;9:340
  6. Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
    Authors: Sepúlveda-Ramírez Et al.
    Dev Biol  2018;437:140
  7. c-Src activity is differentially required by cancer cell motility modes.
    Authors: Logue Et al.
    Oncogene  2018;37:2104
  8. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
    Authors: Ford Et al.
    PLoS Pathog  2018;14:e1007051
  9. Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping.
    Authors: Ray Et al.
    Proc Natl Acad Sci U S A  2018;115:E11568
  10. Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
    Authors: Basu Et al.
    Eneuro  2016;3

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