Inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
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Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Rizvi et al.
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.
Poincloux et al.
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