Chemical Name: 1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione
Biological ActivitySMIFH2 is an inhibitor of formin homology 2 (FH2) domains. Prevents formin-mediated actin nucleation and barbed end elongation. Disrupts formin-dependent actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Rizvi et al.
Contractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.
Poincloux et al.
Citations for SMIFH2
The citations listed below are publications that use Tocris products. Selected citations for SMIFH2 include:
9 Citations: Showing 1 - 9
Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion.
Authors: Alieva Et al.
Nat Commun 2019;10:3593
Differential Toxicity of mDia Formin-Directed Functional Agonists and Antagonists in Developing Zebrafish.
Authors: LeCorgne Et al.
Front Pharmacol 2018;9:340
Cdc42 controls primary mesenchyme cell morphogenesis in the sea urchin embryo.
Authors: Sepúlveda-Ramírez Et al.
Dev Biol 2018;437:140
c-Src activity is differentially required by cancer cell motility modes.
Authors: Logue Et al.
Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry.
Authors: Ford Et al.
PLoS Pathog 2018;14:e1007051
Intrinsic cellular chirality regulates left-right symmetry breaking during cardiac looping.
Authors: Ray Et al.
Proc Natl Acad Sci U S A 2018;115:E11568
Arp2/3 and VASP Are Essential for Fear Memory Formation in Lateral Amygdala.
Authors: Basu Et al.
A dynamic formin-dependent deep F-actin network in axons.
Authors: Ganguly Et al.
J Cell Biol 2015;210:401
ZO-1 controls endothelial adherens junctions, cell-cell tension, angiogenesis, and barrier formation.
Authors: Tornavaca Et al.
J Neurosci 2015;208:821
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