Catalog Number: 3294
Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine
Biological Activity
Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.
Technical Data
  • M.Wt:
    355.43
  • Formula:
    C19H25N5O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    197801-88-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density?
    Sullivan et al.
    Nucl.Med.Biol, 2007;34:353
  2. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors.
    Kumar et al.
    Bioorg.Med.Chem., 2006;14:4029
  3. Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic
    Zhang et al.
    J.Pharm.Exp.Ther., 2003;305:57

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