SN 003

Catalog # Availability Size / Price Qty
3294/10
SN 003 | CAS No. 197801-88-0 | CRF1 Receptor Antagonists
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Description: Potent and selective CRF1 antagonist

Chemical Name: N-(4-Methoxy-2-methylphenyl)-1-[1-(methoxymethyl)propyl]-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine

Purity: ≥98%

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Biological Activity

Reversible corticotropin releasing factor receptor 1 (CRF1) antagonist (Ki values are 3.4 and 7.9 nM at rat and human CRF1 respectively) that displays >1000-fold selectivity over CRF2 receptors. Suppresses CRF-induced ACTH release in vitro (IC50 = 241 nM) and is brain penetrant.

Technical Data

M.Wt:
355.43
Formula:
C19H25N5O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
197801-88-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors.
    Kumar et al.
    Bioorg.Med.Chem., 2006;14:4029
  2. PET imaging of CRF1 with [11C]R121920 and [11C]DMP696: Is the target of sufficient density?
    Sullivan et al.
    Nucl.Med.Biol, 2007;34:353
  3. Pharmacological characterization of a novel nonpeptide antagonist radioligand, (±)-N-[2-Methyl-4-methoxyphenyl]-1-(1-(methoxymethyl) propyl)-6-methyl-1H-1,2,3-triazolo[4,5-c]pyridin-4-amine ([3H]SN003) for cortic
    Zhang et al.
    J.Pharm.Exp.Ther., 2003;305:57

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