SNAP 5089

Name: SNAP 5089
Brand: Tocris Bioscience
SKU: 2398

Catalog #: 2398 Datasheet / COA / SDS

Discontinued Product

2398 has been discontinued.

View all Adrenergic alpha-1 Receptor Antagonists products.

SNAP 5089 | CAS No. 157066-77-8 | Adrenergic alpha-1 Receptor Antagonists

1 Image

Description: Subtype-selective α1A antagonist

Chemical Name: 5-[[[3-(4,4-Diphenyl-1-piperidinyl)propyl]amino]carbonyl]-1,4-dihydro-2,6-dimethyl-4-(4-nitrophenyl)-3-pyridinecarboxylic acid methyl ester hydrochloride

Purity: ≥98%

View All Products for Adrenergic alpha-1 Receptor Antagonists

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SNAP 5089 is a subtype-selective α_1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (K_ivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α_1A, α_1B, α_2C, α_1D, α_2B and α_2A subtypes respectively and 540 nM for L-type Ca²⁺ channels). Inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues.

Technical Data

M.Wt:

645.19

Formula:

C₃₆H₄₀N₄O₅.HCl

Solubility:

Soluble to 100 mM in DMSO and to 100 mM in ethanol

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

157066-77-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of α₁a-adrenergic receptor antagonists based on the L-type Ca²⁺ channel antagonist niguldipine.
Wetzel et al.
J.Med.Chem., 1995;38:1579
Pharmacological characterization of the uroselective alpha-1 antagonist Rec 15-2739 (SB 216469): role of the alpha-1L adrenoceptor in tissue selectivity, Part I.
Leonardi et al.
J.Pharmacol.Exp.Ther., 1997;281:1272
α_1L-adrenceptor mediation of smooth muscle contraction in rabbit bladder neck: a model for lower urinary tract tissues of man.
Kava et al.
Br.J.Pharmacol., 1998;123:1359

Product Datasheets

COA view current batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for SNAP 5089

There are currently no reviews for this product. Be the first to review SNAP 5089 and earn rewards!

Have you used SNAP 5089?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.