SODD/BAG4 Antibody - BSA Free

Novus Biologicals | Catalog # NBP1-76897

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Rat

Applications

Validated:

Western Blot, ELISA, Immunocytochemistry/ Immunofluorescence

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all SODD/BAG4 Primary Antibodies »

Product Specifications

Immunogen

Antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD. The immunogen is located within the first 50 amino acids of SODD. Amino Acid Squence: SALRRSGYGPSDGPS

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

60 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for SODD/BAG4 Antibody - BSA Free

Western Blot: SODD/BAG4 AntibodyBSA Free [NBP1-76897]

Western Blot: SODD/BAG4 AntibodyBSA Free [NBP1-76897]

Western Blot: SODD/BAG4 Antibody [NBP1-76897] - Western blot analysis of SODD in HeLa (1,3) and THP-1 (2,4) whole cell lysates in the absence (1,2) or presence (3,4) of blocking peptide (Catalog no. 2143P) with SODD antibody at 1:500 dilution.
SODD/BAG4 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SODD/BAG4 Antibody - BSA Free [NBP1-76897] -

Immunocytochemistry/ Immunofluorescence: SODD/BAG4 Antibody - BSA Free [NBP1-76897] - Immunofluorescence of SODD/BAG4 in Hela cells with SODD/BAG4 antibody at 20 u/mL.
SODD/BAG4 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: SODD/BAG4 Antibody - BSA Free [NBP1-76897] -

Immunocytochemistry/ Immunofluorescence: SODD/BAG4 Antibody - BSA Free [NBP1-76897] - Immunocytochemistry of SODD/BAG4 in HeLa cells with SODD/BAG4 antibody at 5 u/mL.

Applications for SODD/BAG4 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

5-20 ug/ml

Western Blot

0.5 ug/ml
Application Notes
An approximately 60 kDa band can be detected in Western Blot.

Formulation, Preparation, and Storage

Purification

Ion exchange chromatography

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SODD/BAG4

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

Long Name

Silencer of Death Domains

Alternate Names

BAG4

Gene Symbol

BAG4

UniProt

AF111116 (Human)

Additional SODD/BAG4 Products

Product Documents for SODD/BAG4 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for SODD/BAG4 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Related Research Areas

Apoptosis Adaptor Proteins

Citations for SODD/BAG4 Antibody - BSA Free

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

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Associated Pathways

Apoptosis Signaling Pathway Apoptosis Signaling Pathway Thumbnail