Somatostatin R2/SSTR2 Antibody

Novus Biologicals | Catalog # NB100-74537

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Hamster

Cited:

Human, Rat

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunocytochemistry/ Immunofluorescence

Cited:

Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence, IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Somatostatin R2/SSTR2 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues E(355) T Q R T L L N G D L Q T S I(369) of human SSTR2A.

Specificity

Detects Somatostatin Receptor 2A in human and rat samples.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Somatostatin R2/SSTR2 Antibody

Western Blot: Somatostatin R2/SSTR2 Antibody [NB100-74537]

Western Blot: Somatostatin R2/SSTR2 Antibody [NB100-74537]

Western Blot: Somatostatin R2/SSTR2 Antibody [NB100-74537] - Analysis was performed on whole cell extracts (30 ug lysate) of SH-SY5Y (Lane1), U-87 MG (Lane 2), HeLa (Lane 3) and CaCo-2 (lane 4).
Immunohistochemistry-Paraffin: Somatostatin R2/SSTR2 Antibody [NB100-74537]

Immunohistochemistry-Paraffin: Somatostatin R2/SSTR2 Antibody [NB100-74537]

Immunohistochemistry-Paraffin: Somatostatin R2/SSTR2 Antibody [NB100-74537] - Staining of human pancreatic islands.

Applications for Somatostatin R2/SSTR2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:5000

Immunohistochemistry-Paraffin

1:2500

Western Blot

1:250
Application Notes
ELISA usage was reported in scientific literature (PMID: 21518799). IF usage was reported in scientific literature (PMID: 21519383). Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID: 21493671).

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole serum

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Somatostatin R2/SSTR2

Somatostatin Receptor Type 2 (SST2) expression has been reported in adrenal, aorta, brain, breast, eye, gastrointestinal tract, pancreas, prostate, spinal cord, and thyroid. ESTs have been isolated from brain, eye, head/neck, kidney, lymph node, pineal, and prostate libraries. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Long Name

Somatostatin Receptor Type 2

Alternate Names

Smstr2, SomatostatinR2, SST2, SSTR2

Entrez Gene IDs

54305 (Rat)

Gene Symbol

SSTR2

Additional Somatostatin R2/SSTR2 Products

Product Documents for Somatostatin R2/SSTR2 Antibody

Certificate of Analysis

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Product Specific Notices for Somatostatin R2/SSTR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Somatostatin R2/SSTR2 Antibody

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Protocols

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