Somatostatin R4/SSTR4 Antibody

Novus Biologicals | Catalog # NB100-74539

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot, Immunofluorescence, Immunocytochemistry

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG
View all Somatostatin R4/SSTR4 Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues C(366) Q Q E A L Q P E P G R K R I P L T R T T T F(388) of human SSTR4.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Somatostatin R4/SSTR4 Antibody

Western Blot: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Western Blot: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Western Blot: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of 25 ug of HepG2 (lane 1), Jurkat (lane 2) and NIH-3T3 (lane 3) cell lysates.
Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Immunocytochemistry/Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of NIH-3T3 cells (right) compared to a negative control without primary antibody (left).
Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Immunocytochemistry/ Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539]

Immunocytochemistry/Immunofluorescence: Somatostatin R4/SSTR4 Antibody [NB100-74539] - Analysis of Somatostatin Receptor 4 (green) showing staining in the cytoplasm of SH-SY5Y cells (right) compared to a negative control without primary antibody (left).

Applications for Somatostatin R4/SSTR4 Antibody

Application
Recommended Usage

Immunocytochemistry

1:250

Immunofluorescence

1:250

Immunohistochemistry-Paraffin

1:2500

Western Blot

1:100 - 1:5000
Application Notes
WB: Analysis of SSTR4 transfected HEK-293 cells detects an approx. 40 - 50 kDa protein representing SSTR4.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole serum

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Somatostatin R4/SSTR4

SSTR4 has been reported to be expressed in brain, gastrointestinal tract, pancreas, and prostate tissues. No ESTs have been identified. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.

Long Name

Somatostatin Receptor Type 4

Alternate Names

SomatostatinR4, SS4R, SSTR4

Entrez Gene IDs

6754 (Human)

Gene Symbol

SSTR4

UniProt

P31391 (Human)

Additional Somatostatin R4/SSTR4 Products

Product Documents for Somatostatin R4/SSTR4 Antibody

Certificate of Analysis

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Product Specific Notices for Somatostatin R4/SSTR4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Somatostatin R4/SSTR4 Antibody

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Protocols

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