Catalog Number: 0959
Chemical Name: N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
Biological Activity
Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Activates autophagy.
Technical Data
  • M.Wt:
    254.63
  • Formula:
    C7H19N3.3HCl
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at +4°C
  • CAS No:
    334-50-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats.
    Kishi et al.
    Brain Res., 1998;793:311
  2. Polyamines modulate the neurotoxic effects of NMDA in vivo.
    Munir et al.
    Brain Res., 1993;616:163
  3. Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.
    Williams et al.
    Mol.Pharmacol., 1989;36:375
  4. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;

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