Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3
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Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats.
Kishi et al.
Brain Res., 1998;793:311
Polyamines modulate the neurotoxic effects of NMDA in vivo.
Munir et al.
Brain Res., 1993;616:163
Effects of polyamines on the binding of [3H]-MK801 to the N-methyl-D-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site.
Williams et al.