Catalog Number: 1135
Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine
Biological Activity
A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC50 = 6.2 μM for relaxation of rabbit aorta, and t½ =39 min at 37°C, pH 7.4, aqueous solution).
Technical Data
  • M.Wt:
    262.35
  • Formula:
    C10H26N6O2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    136587-13-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of the NIH, US Patent 5,155,137
Background References
  1. Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production.
    Ferrero et al.
    Br.J.Pharmacol., 1999;127:779
  2. In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries.
    Homer and Wanstall
    Eur.J.Pharmacol., 1998;356:49
  3. Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
    Maragos et al.
    J.Med.Chem., 1991;34:3242
  4. Measurement and modeling of nitric oxide release rates for nitric oxide donors.
    Ramamurthi and Lewis
    Chem.Res.Toxicol., 1997;10:408
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Spermine NONOate include:

1 Citations: Showing 1 - 1

  1. Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.
    Authors: Russell Et al.
    FEBS J 2013;280:6070

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