Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Biological ActivitySplitomicin is a inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Identification of a small molecule inhibitor of Sir2p.
Bedalov et al.
Citations for Splitomicin
The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:
2 Citations: Showing 1 - 2
Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Authors: Stavrou Et al.
J Neurosci 2015;125:710
Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.
Authors: Kumari and Usdin
Hum Mol Genet 2014;23:6575
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