Catalog Number: 1542
Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Biological Activity
Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.
Technical Data
  • M.Wt:
    198.22
  • Formula:
    C13H10O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    5690-03-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Identification of a small molecule inhibitor of Sir2p.
    Bedalov et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:15113
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:

2 Citations: Showing 1 - 2
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  1. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
    Authors: Stavrou Et al.
    J Neurosci 2015;125:710
  2. Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.
    Authors: Kumari and Usdin
    Hum Mol Genet 2014;23:6575

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