Home / Class III Histone Deacetylases Inhibitors / Splitomicin

Splitomicin

1542 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1542/10
1542/50
Splitomicin | CAS No. 5690-03-9 | Class III Histone Deacetylases Inhibitors
1 Image
Description: Sir2p inhibitor

Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

M.Wt:
198.22
Formula:
C13H10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
5690-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a small molecule inhibitor of Sir2p.
    Bedalov et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:15113

Product Datasheets

COA view current batch
Or select another batch:
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for Splitomicin

The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:

2 Citations: Showing 1 - 2

  1. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
    Authors: Stavrou Et al.
    J Neurosci  2015;125:710
  2. Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.
    Authors: Kumari and Usdin
    Hum Mol Genet  2014;23:6575

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Splitomicin

There are currently no reviews for this product. Be the first to review Splitomicin and earn rewards!

Have you used Splitomicin?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.