Splitomicin
Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one
Purity: ≥97%
Biological Activity
Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Identification of a small molecule inhibitor of Sir2p.
Bedalov et al.
Proc.Natl.Acad.Sci.U.S.A., 2001;98:15113
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Citations for Splitomicin
The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:
2 Citations: Showing 1 - 2
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Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
Authors: Stavrou Et al.
J Neurosci 2015;125:710
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Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.
Authors: Kumari and Usdin
Hum Mol Genet 2014;23:6575
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