Splitomicin

Catalog # Availability Size / Price Qty
1542/10
1542/50
Class III Histone Deacetylases Inhibitors Small Molecule
1 Image
Description: Sir2p inhibitor

Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Purity: ≥97%

Product Details
Citations (2)
Reviews

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

M.Wt:
198.22
Formula:
C13H10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
5690-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a small molecule inhibitor of Sir2p.
    Bedalov et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:15113

Product Datasheets

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Citations for Splitomicin

The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:

2 Citations: Showing 1 - 2

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