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Splitomicin

1542 2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
1542/10
1542/50
Class III Histone Deacetylases Inhibitors Small Molecule
1 Image
Description: Sir2p inhibitor

Chemical Name: 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Inhibitor of Sir2p (IC50 = 60 μM), an NAD+-dependent Sir2 family deacetylase required for chromatin-dependent silencing in yeast.

Technical Data

M.Wt:
198.22
Formula:
C13H10O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
5690-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification of a small molecule inhibitor of Sir2p.
    Bedalov et al.
    Proc.Natl.Acad.Sci.U.S.A., 2001;98:15113

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Citations for Splitomicin

The citations listed below are publications that use Tocris products. Selected citations for Splitomicin include:

2 Citations: Showing 1 - 2

  1. Reduced thrombosis in Klkb1-/- mice is mediated by increased Mas receptor, prostacyclin, Sirt1, and KLF4 and decreased tissue factor.
    Authors: Stavrou Et al.
    J Neurosci  2015;125:710
  2. Polycomb group complexes are recruited to reactivated FMR1 alleles in Fragile X syndrome in response to FMR1 transcription.
    Authors: Kumari and Usdin
    Hum Mol Genet  2014;23:6575

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