SR 1001

Catalog # Availability Size / Price Qty
4868/10
4868/50
Cat.No. 4868 - SR 1001 | C15H13F6N3O4S2 | CAS No. 1335106-03-0
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Description: RORα/γ inverse agonist

Chemical Name: N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide

Purity: ≥98%

Product Details
Reviews

Biological Activity

Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.

Technical Data

M.Wt:
477.4
Formula:
C15H13F6N3O4S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1335106-03-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Additional Information

Licensing Caveats:
Sold under license from The Scripps Research Institute.

Product Datasheets

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