Chemical Name: N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
Biological ActivityRetinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt et al.
Inflammatory T helper 17 cells promote depression-like behavior in mice.
Beurel et al.
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley et al.
PLoS ONE, 2012;7:33804
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