Retinoic acid receptor-related orphan receptor (ROR) α
inverse agonist (Ki
values are 172 and 111 nM for RORα
respectively). Demonstrates no activity at RORβ
or LXR. Suppresses Th
17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.
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Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt et al.
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley et al.
PLoS ONE, 2012;7:33804
Inflammatory T helper 17 cells promote depression-like behavior in mice.
Beurel et al.