SR 1001
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Description: RORα/γ inverse agonist
Chemical Name: N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
Purity: ≥98%
Biological Activity
Retinoic acid receptor-related orphan receptor (ROR) α and γ inverse agonist (Ki values are 172 and 111 nM respectively). Demonstrates no activity at RORβ or LXR. Suppresses Th17 cell differentiation and cytokine expression and reduces the severity of disease in an animal model of mulitple sclerosis.Technical Data
M.Wt:
477.4
Formula:
C15H13F6N3O4S2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1335106-03-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold under license from The Scripps Research Institute.
Background References
-
Inflammatory T helper 17 cells promote depression-like behavior in mice.
Beurel et al.
Biol.Psychiatry, 2013;73:622 -
Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand.
Solt et al.
Nature, 2011;472:491 -
Regulation of expression of citrate synthase by the retinoic acid receptor-related orphan receptor α (RORα).
Crumbley et al.
PLoS ONE, 2012;7:33804
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