Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Biological ActivitySR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
Shiohara et al.
Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
Huang et al.
A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.
Fanjul et al.
Citations for SR 11302
The citations listed below are publications that use Tocris products. Selected citations for SR 11302 include:
26 Citations: Showing 1 - 10
Butyrate Produced by Commensal Bacteria Down-Regulates Indolamine 2,3-Dioxygenase 1 (IDO-1) Expression via a Dual Mechanism in Human Intestinal Epithelial Cells.
Authors: Martin-Gallausiaux Et al.
Front Immunol 2019;9:2838
IL-33 stimulates human mast cell release of CCL5 and CCL2 via MAPK and NF-κB, inhibited by methoxyluteolin.
Authors: Bawazeer and Theoharides
Eur J Pharmacol 2019;865
Osmotic induction of cyclooxygenase-2 in RPE cells: Stimulation of inflammasome activation.
Authors: Messerschmidt Et al.
Mol Vis 2019;25:329
TGF-β1 expression in regulatory NK1.1-CD4+NKG2D+ T cells dependents on the PI3K-p85α/JNK, NF-κB and STAT3 pathways.
Authors: Han Et al.
Am J Cancer Res 2018;8:489
Elevated sodium chloride drives type I IF. signaling in macrophages and increases antiviral resistance.
Authors: Zhang Et al.
J Biol Chem 2018;293:1030
Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells.
Authors: Kim Et al.
Cell Rep 2018;25:2148
Activator protein-1 contributes to the NaCl-induced expression of VEGF and PlGF in RPE cells.
Authors: Kleiner Et al.
Mol Vis 2018;24:647
Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.
Authors: Sun Et al.
J Exp Med 2017;214:1753
Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.
Authors: Bugel Et al.
Toxicol Appl Pharmacol 2016;296:31
Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II.
Authors: Lee Et al.
PLoS One 2016;11:e0163415
Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression.
Authors: Lee Et al.
The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization.
Authors: Zheng Et al.
Invest Ophthalmol Vis Sci 2015;5:14408
p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.
Authors: Huang Et al.
Int J Gynecol Cancer 2015;3:225
Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway.
Authors: Chen Et al.
Sci Rep 2015;25:953
Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
Authors: Nadeau-Vallée Et al.
J Immunol 2015;195:3402
NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
Authors: Banskota Et al.
Mol Cancer 2015;14:123
Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
Authors: Oruqaj Et al.
Proc Natl Acad Sci U S A 2015;112:E2048
Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells.
Authors: O'Sullivan Et al.
PLoS One 2014;9:e95566
Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
Authors: Pernet Et al.
Nat Commun 2014;5:5105
Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
Authors: Kim Et al.
Eur J Immunol 2014;44:807
Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.
Authors: Mason Et al.
Drug Metab Dispos 2014;42:2077
BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
Authors: Bakhru Et al.
Cell Immunol 2014;287:53
Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
Authors: Vliet Et al.
J Biol Chem 2013;288:27519
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Authors: Keasey Et al.
Cell Commun Signal 2013;11:35
Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.
Authors: Sethi Et al.
PLoS One 2011;52:5240
Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
Authors: Ivanova Et al.
FASEB J 2011;25:1402
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Effect of (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid) drug after HSC treatment.