SR 11302

  ( 18 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2476
Chemical Name:(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Product Details
Citations (18)
Reviews
Biological Activity
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
Technical Data
  • M.Wt:
    376.54
  • Formula:
    C26H32O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98
  • Storage:
    Store at -20°C
  • CAS No:
    160162-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 11302 include:

18 Citations: Showing 1 - 10
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  1. Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium.
    Authors: Bugel Et al.
    Toxicol Appl Pharmacol  2016;296:31
  2. Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II.
    Authors: Lee Et al.
    PLoS One  2016;11:e0163415
  3. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression.
    Authors: Lee Et al.
    Oncotarget  2015;6:22139
  4. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization.
    Authors: Zheng Et al.
    Invest Ophthalmol Vis Sci  2015;5:14408
  5. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.
    Authors: Huang Et al.
    Int J Gynecol Cancer  2015;3:225
  6. Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway.
    Authors: Chen Et al.
    Sci Rep  2015;25:953
  7. Novel Noncompetitive IL-1 Receptor-Biased Ligand Prevents Infection- and Inflammation-Induced Preterm Birth.
    Authors: Nadeau-Vall&eacutee Et al.
    J Immunol  2015;195:3402
  8. NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
    Authors: Banskota Et al.
    Mol Cancer  2015;14:123
  9. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A  2015;112:E2048
  10. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells.
    Authors: O'Sullivan Et al.
    PLoS One  2014;9:e95566
  11. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun  2014;5:5105
  12. Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
    Authors: Kim Et al.
    Eur J Immunol  2014;44:807
  13. Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.
    Authors: Mason Et al.
    Drug Metab Dispos  2014;42:2077
  14. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
    Authors: Bakhru Et al.
    Cell Immunol  2014;287:53
  15. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem  2013;288:27519
  16. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  17. Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.
    Authors: Sethi Et al.
    PLoS One  2011;52:5240
  18. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
    Authors: Ivanova Et al.
    FASEB J  2011;25:1402
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Average Rating: 5 (Based on 1 review)

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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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