Catalog Number: 2476
Chemical Name: (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
Biological Activity
Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC50 > 1 μM for RARα, RARβ, RARγ and RXRα).
Technical Data
  • M.Wt:
    376.54
  • Formula:
    C26H32O2
  • Solubility:
    Soluble to 100 mM in DMSO and to 10 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    160162-42-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of novel RAR- and RXR-selective retinoids on myeloid leukemic proliferation and differentiation in vitro.
    Shiohara et al.
    Blood, 1999;93:2057
  2. A new class of retinoids with selective inhibition of AP-1 inhibits proliferation.
    Fanjul et al.
    Nature, 1994;372:107
  3. Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid.
    Huang et al.
    Proc.Natl.Acad.Sci.USA, 1997;94:5826
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SR 11302 include:

16 Citations: Showing 1 - 10
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  1. Alternative Splicing of Toll-Like Receptor 9 Transcript in Teleost Fish Grouper Is Regulated by NF-& #954;B Signaling via Phosphorylation of the C-Terminal Domain of the RPB1 Subunit of RNA Polymerase II.
    Authors: Lee Et al.
    PLoS One 2016;11:e0163415
  2. Anti-cancer effect of snake venom toxin through down regulation of AP-1 mediated PRDX6 expression.
    Authors: Lee Et al.
    Oncotarget 2015;6:22139
  3. The AP-1 transcription factor homolog Pf-AP-1 activates transcription of multiple biomineral proteins and potentially participates in Pinctada fucata biomineralization.
    Authors: Zheng Et al.
    Invest Ophthalmol Vis Sci 2015;5:14408
  4. p38 mitogen-activated protein kinase/activator protein-1 involved in serum deprivation-induced human alkaline ceramidase 2 upregulation.
    Authors: Huang Et al.
    Int J Gynecol Cancer 2015;3:225
  5. Adrenomedullin Up-regulates the Expression of Vascular Endothelial Growth Factor in Epithelial Ovarian Carcinoma Cells via JNK/AP-1 Pathway.
    Authors: Chen Et al.
    Sci Rep 2015;25:953
  6. NOX1 to NOX2 switch deactivates AMPK and induces invasive phenotype in colon cancer cells through overexpression of MMP-7.
    Authors: Banskota Et al.
    Mol Cancer 2015;14:123
  7. Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling.
    Authors: Oruqaj Et al.
    Proc Natl Acad Sci U S A 2015;112:E2048
  8. Sphingosine 1-phosphate (S1P) induced interleukin-8 (IL-8) release is mediated by S1P receptor 2 and nuclear factor κB in BEAS-2B cells.
    Authors: O'Sullivan Et al.
    PLoS One 2014;9:e95566
  9. Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity.
    Authors: Pernet Et al.
    Nat Commun 2014;5:5105
  10. Self-priming determines high type I IFN production by plasmacytoid dendritic cells.
    Authors: Kim Et al.
    Eur J Immunol 2014;44:807
  11. Effect of prostaglandin E2 on multidrug resistance transporters in human placental cells.
    Authors: Mason Et al.
    Drug Metab Dispos 2014;42:2077
  12. BCG vaccine mediated reduction in the MHC-II expression of macrophages and dendritic cells is reversed by activation of Toll-like receptors 7 and 9.
    Authors: Bakhru Et al.
    Cell Immunol 2014;287:53
  13. Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL).
    Authors: Vliet Et al.
    J Biol Chem 2013;288:27519
  14. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal 2013;11:35
  15. Transforming growth factor-β induces extracellular matrix protein cross-linking lysyl oxidase (LOX) genes in human trabecular meshwork cells.
    Authors: Sethi Et al.
    PLoS One 2011;52:5240
  16. Tamoxifen increases nuclear respiratory factor 1 transcription by activating estrogen receptor beta and AP-1 recruitment to adjacent promoter binding sites.
    Authors: Ivanova Et al.
    FASEB J 2011;25:1402
Expand to show all 16 Citations

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