Selective, competitive GABAA
receptor antagonist. Displaces [3
H]-GABA from rat brain membranes with a Ki
of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl-
currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
The kinetics of inhibition of rat recombinant heterotrimeric α1β glycine receptors by the low affinity antagonist SR-95531.
Beato et al.
Biochemical characterization of the interaction of three pyridazinyl-GABA derivatives with the GABAA receptor site.
Heaulme et al.
Brain Res., 1986;384:224
The differential antagonism by bicuculline and SR95531 of pentobarbitone-induced currents in cultured hippocampal neurons.
Uchida et al.
The citations listed below are publications that use Tocris products. Selected citations for SR 95531 hydrobromide include:
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