SR 95531 hydrobromide

Catalog # Availability Size / Price Qty
1262/10
1262/50
SR 95531 hydrobromide | CAS No. 104104-50-9 | GABA-A Receptor Antagonists
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Description: Competitive and selective GABAA antagonist
Alternative Names: Gabazine

Chemical Name: 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

Product Details
Citations (165)
Supplemental Products
Reviews (1)

Biological Activity

Selective, competitive GABAA receptor antagonist. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Technical Data

Formula:
C15H17N3O3.HBr
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Storage:
Store the unopened product at room temperature. Do not use past expiration date.
CAS No:
104104-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SR 95531 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SR 95531 hydrobromide include:

165 Citations: Showing 1 - 10

  1. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
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    Cell Rep  2019;27:860
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    Front Cell Neurosci  2019;13:27
  3. Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.
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    Front Synaptic Neurosci  2019;11:16
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    Neuron  2019;
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    Nat.Commun.  2018;9:4163
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    Neuron  2018;98:366
  7. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
    Authors: Lozovaya Et al.
    Nat Commun  2018;9(1):1422
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    Nature  2018;564:213
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    J Neurosci  2018;38:7713
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    J Neurosci  2018;38:347
  12. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
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    Cell  2018;174:1450
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    Neuron  2017;95:656
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    Neuron  2017;95:1319
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  30. 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
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  31. Cell-Autonomous Regulation of Dendritic Spine Density by PirB.
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    Eneuro  2016;3
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  33. Diminished KCC2 confounds synapse specificity of LTP during senescence.
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  34. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
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    Endocrinology.  2016;157:3621
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    Microvasc Res  2015;9:6
  36. Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain.
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    Elife  2015;9:309
  37. Stretch induced hyperexcitability of mice callosal pathway.
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    J Neurophysiol  2015;9:292
  38. An excitatory GABA loop operating in vivo.
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    Front Cell Neurosci  2015;9:275
  39. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci  2015;9:272
  40. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurosci  2015;9:115
  41. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Front Cell Neurosci  2015;85:549
  42. Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain.
    Authors: Winkelmann Et al.
    Cell Death Dis  2015;6:e1776
  43. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    Front Cell Neurosci  2015;6:8076
  44. RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.
    Authors: Wang Et al.
    Sci Rep  2015;5:17383
  45. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  46. CaRuby-Nano: a novel high affinity calcium probe for dual color imaging.
    Authors: Collot Et al.
    Front Cell Neurosci  2015;4
  47. An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina.
    Authors: Kim Et al.
    Elife  2015;4
  48. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Elife  2015;4
  49. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.
    Authors: Hirono Et al.
    Eneuro  2015;35:7082
  50. Prototypic and arkypallidal neurons in the DA-intact external globus pallidus.
    Authors: Abdi Et al.
    J Neurosci  2015;35:6667
  51. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    J Negat Results Biomed  2015;35:5680
  52. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Physiol Rep  2015;35:5664
  53. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  54. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    Brain  2015;35:13336
  55. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  56. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    PLoS One  2015;3
  57. Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.
    Authors: Cantu Et al.
    Cereb Cortex  2015;25:2306
  58. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  59. Ethanol exposure during the third trimester equivalent does not affect GABAA or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons.
    Authors: Baculis and Valenzuela
    J Neurophysiol  2015;14:19
  60. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    PLoS One  2015;112:E1956
  61. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    Authors: Wang Et al.
    Eneuro  2015;10:e0139332
  62. The effect of Dflu. on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    Nat Commun  2015;10:e0123534
  63. Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.
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    PLoS One  2014;9:e85865
  64. Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells.
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    PLoS One  2014;9:e114330
  65. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia.
    Authors: Jones Et al.
    Nature  2014;9:e109303
  66. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
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    PLoS One  2014;9:e106316
  67. CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons.
    Authors: Straub Et al.
    J Neurophysiol  2014;9:e105584
  68. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
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    Front Neural Circuits  2014;8:83
  69. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.
    Authors: Armbruster Et al.
    Front Cell Neurosci  2014;8:277
  70. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
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    Front Cell Neurosci  2014;8:246
  71. Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes.
    Authors: Schönberger Et al.
    J Cereb Blood Flow Metab  2014;8:103
  72. DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
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    PLoS One  2014;81:901
  73. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    J Neurophysiol  2014;7:89
  74. Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex.
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    Front Neuroanat  2014;7:52
  75. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
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    Nat Neurosci  2014;509:195
  76. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
  77. Gap junction networks can generate both ripple-like and fast ripple-like oscillations.
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    Eur J Neurosci  2014;39:46
  78. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
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    J Cereb Blood Flow Metab  2014;34:397
  79. Three distinct blue-green color pathways in a mammalian retina.
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    J Neurosci  2014;34:1760
  80. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by DA in the Basolateral Amygdala.
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  81. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
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  82. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
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  83. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.
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    Authors: Akrouh and Kerschensteiner
    Neuron  2013;79:322
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  125. High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
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    J Neurosci  2010;30:3600
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  134. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
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  135. Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.
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    Chem Senses  2009;29:12440
  140. PropF. inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
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    Am J Physiol Cell Physiol  2009;296:C1400
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  142. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
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  143. Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.
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    Cereb Cortex  2009;102:2208
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    Authors: Maher and Westbrook
    J Neurophysiol  2008;99:1559
  145. Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys.
    Authors: Darbin and Wichmann
    Front Cell Neurosci  2008;99:1294
  146. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron  2008;58:925
  147. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
    Authors: Kotak Et al.
    Cereb Cortex  2008;18:2098
  148. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    J Neurosci  2008;105:746
  149. Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission.
    Authors: Madara and Levine
    J Neurophysiol  2008;100:3175
  150. Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
    Authors: Fanselow Et al.
    J Neurophysiol  2008;100:2640
  151. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
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    J Neurophysiol  2008;100:1897
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SR95531 for slice electrophysiology
By Anonymous on 01/08/2018
Species: Mouse

I use SR95531 to block GABAA channels when performing slice electrophysiology.


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