SR 95531 hydrobromide

Catalog # Availability Size / Price Qty
1262/10
1262/50
SR 95531 hydrobromide | CAS No. 104104-50-9 | GABA-A Receptor Antagonists
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Description: Competitive and selective GABAA antagonist
Alternative Names: Gabazine

Chemical Name: 6-Imino-3-(4-methoxyphenyl)-1(6H)-pyridazinebutanoic acid hydrobromide

Purity: ≥98%

Product Details
Citations (169)
Supplemental Products
Reviews (1)

Biological Activity

Selective, competitive GABAA receptor antagonist. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike bicuculline, selectively antagonizes GABA-induced Cl- currents with little action on pentobarbitone-induced currents. Also acts as a low affinity glycine receptor antagonist.

Technical Data

M.Wt:
368.23
Formula:
C15H17N3O3.HBr
Solubility:
Soluble to 25 mM in water and to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
104104-50-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SR 95531 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SR 95531 hydrobromide include:

169 Citations: Showing 1 - 10

  1. Axonal mechanisms mediating γ-aminobutyric acid receptor type A (GABA-A) inhibition of striatal dopamine release
    Authors: Kramer Et al.
    ELife  2020;9
  2. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons.
    Authors: Evans Et al.
    Cell Rep  2020;32
  3. Hippocampal hub neurons maintain distinct connectivity throughout their lifetime.
    Authors: Bocchio Et al.
    Nat Commun  2020;11:4559
  4. Voltage-gated potassium channels ensure action potential shape fidelity in distal axons.
    Authors: Sabater Et al.
    BioRXiv - not yet peer reviewed  2020;
  5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST.
    Authors: Nakano Et al.
    Cell Rep  2019;27:860
  6. Functional Coupling of Cav2.3 and BK Potassium Channels Regulates Action Potential Repolarization and Short-Term Plasticity in the Mouse Hippocampus.
    Authors: Gutzmann Et al.
    Front Cell Neurosci  2019;13:27
  7. Optically Induced Calcium-Dependent Gene Activation and Labeling of Active Neurons Using CaMPARI and Cal-Light.
    Authors: Ebner Et al.
    Front Synaptic Neurosci  2019;11:16
  8. A Retinal Circuit Generating a Dynamic Predictive Code for Oriented Features.
    Authors: Johnston Et al.
    Neuron  2019;
  9. A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics.
    Authors: Meira Et al.
    Nat.Commun.  2018;9:4163
  10. Reciprocal Circuits Linking the Prefrontal Cortex with Dorsal and Ventral Thalamic Nuclei.
    Authors: Collins Et al.
    Neuron  2018;98:366
  11. GABAergic inhibition in dual-transmission cholinergic and GABAergic striatal interneurons is abolished in Parkinson disease.
    Authors: Lozovaya Et al.
    Nat Commun  2018;9(1):1422
  12. OXT functions as a spatiotemporal filter for excitatory synaptic inputs to VTA DA neurons.
    Authors: Xiao Et al.
    Elife  2018;7
  13. A circuit from hippocampal CA2 to lateral septum disinhibits social aggression.
    Authors: Leroy Et al.
    Nature  2018;564:213
  14. Cerebrospinal Fluid-Contacting Neurons Sense pH Changes and Motion in the Hypothalamus.
    Authors: Jalalvand Et al.
    J Neurosci  2018;38:7713
  15. The Mouse Pulvinar Nucleus Links the Lateral Extrastriate Cortex, Striatum, and Amygdala.
    Authors: Zhou Et al.
    J Neurosci  2018;38:347
  16. Heparan Sulfate Organizes Neuronal Synapses through Neurexin Partnerships.
    Authors: Zhang Et al.
    Cell  2018;174:1450
  17. Proximodistal Heterogeneity of Hippocampal CA3 Pyramidal Neuron Intrinsic Properties, Connectivity, and Reactivation during Memory Recall.
    Authors: Sun Et al.
    Neuron  2017;95:656
  18. Biased OXTergic Modulation of Midbrain DA Systems.
    Authors: Xiao Et al.
    Neuron  2017;95:368
  19. Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference.
    Authors: Dulcis Et al.
    Neuron  2017;95:1319
  20. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory.
    Authors: Leroy Et al.
    Neuron  2017;95:1089
  21. Chronic Loss of CA2 Transmission Leads to Hippocampal Hyperexcitability.
    Authors: Boehringer Et al.
    Neuron  2017;94:642
  22. Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons.
    Authors: Athilingam Et al.
    Elife  2017;6
  23. Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
    Authors: Leyrer-Jackson
    Physiol Rep  2017;5(22):e13499
  24. Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex.
    Authors: Ibrahim Et al.
    Pflugers Arch  2017;469:1631
  25. DA Regulation of GABAA Receptors Contributes to Light/Dark Modulation of the ON-Cone Bipolar Cell Receptive Field Surround in the Retina.
    Authors: Chaffiol Et al.
    Curr Biol  2017;27:2600
  26. Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
    Authors: Hull
    Cold Spring Harb Protoc  2017;2017
  27. Ion channel expression patterns in glioblastoma stem cells with functional and therapeutic implications for malignancy.
    Authors: Pollak Et al.
    PLoS One  2017;12:e0172884
  28. Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells.
    Authors: Hirono
    Neuropharmacology  2017;118:79
  29. Spontaneous release regulates synaptic scaling in the embryonic spinal network in vivo.
    Authors: Miguel Angel Garcia-Bereguiain Et al.
    The Journal of Neuroscience  2016;6:7268
  30. Differential somatic Ca2+ channel profile in midbrain DArgic neurons.
    Authors: Philippart Et al.
    The Journal of Neuroscience  2016;6:7234
  31. Cortico-fugal output from visual cortex promotes plasticity of innate motor behaviour.
    Authors: Liu Et al.
    Nature  2016;538:383
  32. A cholinergic basal forebrain feeding circuit modulates appetite suppression
    Authors: Herman Et al.
    Nature  2016;538:253
  33. A deleterious Nav1.1 mutation selectively impairs telencephalic inhibitory neurons derived from Dravet Syndrome patients.
    Authors: Sun Et al.
    Elife  2016;5
  34. 17β-OE Acutely Potentiates Glutamatergic Synaptic Transmission in the Hippocampus through Distinct Mechanisms in Males and Females.
    Authors: Oberlander
    J Neurosci  2016;36:2677
  35. Cell-Autonomous Regulation of Dendritic Spine Density by PirB.
    Authors: Vidal Et al.
    Eneuro  2016;3
  36. Electrophysiological Assessment of Serotonin and GABA Neuron Function in the Dorsal Raphe during the Third Trimester Equivalent Developmental Period in Mice(1,2,3).
    Authors: Morton Et al.
    Proc Natl Acad Sci U S A  2016;2
  37. Diminished KCC2 confounds synapse specificity of LTP during senescence.
    Authors: Ferando Et al.
    Nat Neurosci  2016;19:1197
  38. Vasoactive Intestinal Peptide Excites GnRH Neurons in Male and Female Mice.
    Authors: Piet Et al.
    Endocrinology.  2016;157:3621
  39. Acetylcholine induces GABA release onto rod bipolar cells through heteromeric nicotinic receptors expressed in A17 amacrine cells.
    Authors: Elgueta Et al.
    Microvasc Res  2015;9:6
  40. Cell-type-specific tuning of Cav1.3 Ca(2+)-channels by a C-terminal automodulatory domain.
    Authors: Scharinger Et al.
    Elife  2015;9:309
  41. Stretch induced hyperexcitability of mice callosal pathway.
    Authors: Fan Et al.
    J Neurophysiol  2015;9:292
  42. An excitatory GABA loop operating in vivo.
    Authors: Astorga Et al.
    Front Cell Neurosci  2015;9:275
  43. Interaction of electrically evoked activity with intrinsic dynamics of cultured cortical networks with and without functional fast GABAergic synaptic transmission.
    Authors: Baltz and Voigt
    Front Cell Neurosci  2015;9:272
  44. Acetylcholine release in mouse hippocampal CA1 preferentially activates inhibitory-selective interneurons via α4β2* nicotinic receptor activation.
    Authors: Bell Et al.
    J Neurosci  2015;9:115
  45. High salt intake increases blood pressure via BDNF-mediated downregulation of KCC2 and impaired baroreflex inhibition of vasopressin neurons.
    Authors: Choe Et al.
    Front Cell Neurosci  2015;85:549
  46. Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain.
    Authors: Winkelmann Et al.
    Cell Death Dis  2015;6:e1776
  47. Optical control of NMDA receptors with a diffusible photoswitch.
    Authors: Laprell Et al.
    Front Cell Neurosci  2015;6:8076
  48. RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function.
    Authors: Wang Et al.
    Sci Rep  2015;5:17383
  49. Increased serotonin transporter expression reduces fear and recruitment of parvalbumin interneurons of the amygdala.
    Authors: Bocchio Et al.
    Neuropsychopharmacology  2015;40:3015
  50. Corelease of acetylcholine and GABA from cholinergic forebrain neurons.
    Authors: Saunders Et al.
    Elife  2015;4
  51. An excitatory amacrine cell detects object motion and provides feature-selective input to ganglion cells in the mouse retina.
    Authors: Kim Et al.
    Elife  2015;4
  52. CaRuby-Nano: a novel high affinity calcium probe for dual color imaging.
    Authors: Collot Et al.
    Front Cell Neurosci  2015;4
  53. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells.
    Authors: Hirono Et al.
    Eneuro  2015;35:7082
  54. Prototypic and arkypallidal neurons in the DA-intact external globus pallidus.
    Authors: Abdi Et al.
    J Neurosci  2015;35:6667
  55. Muscarinic receptors modulate dendrodendritic inhibitory synapses to sculpt glomerular output.
    Authors: Liu Et al.
    J Negat Results Biomed  2015;35:5680
  56. Abnormal excitability and episodic low-frequency oscillations in the cerebral cortex of the tottering mouse.
    Authors: Cramer Et al.
    Physiol Rep  2015;35:5664
  57. Ectopic Expression of α6 and δ GABAA Receptor Subunits in Hilar Somatostatin Neurons Increases Tonic Inhibition and Alters Network Activity in the Dentate Gyrus.
    Authors: Tong Et al.
    J Neurosci  2015;35:16142
  58. The Synaptic and Morphological Basis of Orientation Selectivity in a Polyaxonal Amacrine Cell of the Rabbit Retina.
    Authors: Murphy-Baum and Taylor
    Brain  2015;35:13336
  59. Sex Differences in Molecular Signaling at Inhibitory Synapses in the Hippocampus.
    Authors: Tabatadze Et al.
    J Neurosci  2015;35:11252
  60. Afterhyperpolarization (AHP) regulates the frequency and timing of action potentials in the mitral cells of the olfactory bulb: role of olfactory experience.
    Authors: Duménieu Et al.
    PLoS One  2015;3
  61. Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control.
    Authors: Cantu Et al.
    Cereb Cortex  2015;25:2306
  62. Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3).
    Authors: Polito Et al.
    J Neurosci  2015;2
  63. Ethanol exposure during the third trimester equivalent does not affect GABAA or AMPA receptor-mediated spontaneous synaptic transmission in rat CA3 pyramidal neurons.
    Authors: Baculis and Valenzuela
    J Neurophysiol  2015;14:19
  64. Tectal microcircuit generating visual selection commands on gaze-controlling neurons.
    Authors: Kardamakis Et al.
    PLoS One  2015;112:E1956
  65. Apamin Boosting of Synaptic Potentials in CaV2.3 R-Type Ca2+ Channel Null Mice.
    Authors: Wang Et al.
    Eneuro  2015;10:e0139332
  66. The effect of Dflu. on neuronal communication at a central synapse.
    Authors: Mapelli Et al.
    Nat Commun  2015;10:e0123534
  67. Spatially reciprocal inhibition of inhibition within a stimulus selection network in the avian midbrain.
    Authors: Goddard Et al.
    PLoS One  2014;9:e85865
  68. Nitric oxide modulates the temporal properties of the glutamate response in type 4 OFF bipolar cells.
    Authors: Vielma Et al.
    PLoS One  2014;9:e114330
  69. Neonatal NMDA receptor blockade disrupts spike timing and glutamatergic synapses in fast spiking interneurons in a NMDA receptor hypofunction model of schizophrenia.
    Authors: Jones Et al.
    Nature  2014;9:e109303
  70. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways.
    Authors: Kubota Et al.
    PLoS One  2014;9:e106316
  71. CRISPR/Cas9-mediated gene knock-down in post-mitotic neurons.
    Authors: Straub Et al.
    J Neurophysiol  2014;9:e105584
  72. Inhibitory projections from the ventral nucleus of the trapezoid body to the medial nucleus of the trapezoid body in the mouse.
    Authors: Albrecht Et al.
    Front Neural Circuits  2014;8:83
  73. Laser-scanning astrocyte mapping reveals increased glutamate-responsive domain size and disrupted maturation of glutamate uptake following neonatal cortical freeze-lesion.
    Authors: Armbruster Et al.
    Front Cell Neurosci  2014;8:277
  74. Regulation of output spike patterns by phasic inhibition in cerebellar granule cells.
    Authors: Nieus Et al.
    Front Cell Neurosci  2014;8:246
  75. Lamina-specific contribution of glutamatergic and GABAergic potentials to hippocampal sharp wave-ripple complexes.
    Authors: Schönberger Et al.
    J Cereb Blood Flow Metab  2014;8:103
  76. DA neurons control striatal cholinergic neurons via regionally heterogeneous DA and glutamate signaling.
    Authors: Chuhma Et al.
    PLoS One  2014;81:901
  77. HSF1 transcriptional activity mediates alcohol induction of Vamp2 expression and GABA release.
    Authors: Varodayan and Harrison
    J Neurophysiol  2014;7:89
  78. Synaptic and cellular organization of layer 1 of the developing rat somatosensory cortex.
    Authors: Muralidhar Et al.
    Front Neuroanat  2014;7:52
  79. Synapse elimination and learning rules co-regulated by MHC class I H2-Db.
    Authors: Lee Et al.
    Nat Neurosci  2014;509:195
  80. Cross-synaptic synchrony and transmission of signal and noise across the mouse retina.
    Authors: Grimes Et al.
    Elife  2014;3:e03892
  81. Gap junction networks can generate both ripple-like and fast ripple-like oscillations.
    Authors: Simon Et al.
    Eur J Neurosci  2014;39:46
  82. Glycolysis and oxidative phosphorylation in neurons and astrocytes during network activity in hippocampal slices.
    Authors: Ivanov Et al.
    J Cereb Blood Flow Metab  2014;34:397
  83. Three distinct blue-green color pathways in a mammalian retina.
    Authors: Mills Et al.
    J Neurosci  2014;34:1760
  84. Moderate Alcohol Exposure during the Rat Equivalent to the Third Trimester of Human Pregnancy Alters Regulation of GABAA Receptor-Mediated Synaptic Transmission by DA in the Basolateral Amygdala.
    Authors: Diaz Et al.
    J Neurosci  2014;2:46
  85. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra DA neurons.
    Authors: Dragicevic Et al.
    Neuron  2014;137:2287
  86. Depressed GABA and glutamate synaptic signaling by 5-HT1A receptors in the nucleus tractus solitarii and their role in cardiorespiratory function.
    Authors: Ostrowski Et al.
    J Neurosci  2014;111:2493
  87. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons.
    Authors: Mariqueo Et al.
    Front Pediatr  2014;111:1940
  88. GPR35 activation reduces Ca2+ transients and contributes to the kynurenic acid-dependent reduction of synaptic activity at CA3-CA1 synapses.
    Authors: Berlinguer-Palmini Et al.
    PLoS One  2013;8:e82180
  89. Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa.
    Authors: Jensen
    PLoS One  2013;8:e79126
  90. Intersecting circuits generate precisely patterned retinal waves.
    Authors: Akrouh and Kerschensteiner
    Neuron  2013;79:322
  91. Weaker control of the electrical properties of cerebellar granule cells by tonically active GABAA receptors in the Ts65Dn mouse model of Down's syndrome.
    Authors: Szemes Et al.
    Mol Brain  2013;6:33
  92. Properties of the ON bistratified ganglion cell in the rabbit retina.
    Authors: Hoshi Et al.
    J Comp Neurol  2013;521:1497
  93. Autism-related deficits via dysregulated eIF4E-dependent translational control.
    Authors: Gkogkas Et al.
    Proc Natl Acad Sci U S A  2013;493:371
  94. Postnatal loss of P/Q-type channels confined to rhombic-lip-derived neurons alters synaptic transmission at the parallel fiber to purkinje cell synapse and replicates genomic Cacna1a mutation phenotype of ataxia and seizures in mice.
    Authors: Maejima Et al.
    J Neurosci  2013;33:5162
  95. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus.
    Authors: Caiati Et al.
    J Neurosci  2013;33:2973
  96. Ovarian hormone loss impairs excitatory synaptic transmission at hippocampal CA3-CA1 synapses.
    Authors: Wu Et al.
    J Neurosci  2013;33:16158
  97. A reorganized GABAergic circuit in a model of epilepsy: evidence from optogenetic labeling and stimulation of somatostatin interneurons.
    Authors: Peng Et al.
    PLoS One  2013;33:14392
  98. Behavioural and functional characterization of Kv10.1 (Eag1) knockout mice.
    Authors: Ufartes Et al.
    Hum Mol Genet  2013;22:2247
  99. GABA(A) receptors implicated in REM sleep control express a benzodiazepine binding site.
    Authors: Nguyen Et al.
    J Biol Chem  2013;1527:131
  100. Synaptic and extrasynaptic transmission of kidney-related neurons in the rostral ventrolateral medulla.
    Authors: Gao and Derbenev
    J Neurosci  2013;110:2637
  101. Contribution of near-threshold currents to intrinsic oscillatory activity in rat medial entorhinal cortex layer II stellate cells.
    Authors: Boehlen Et al.
    J Neurophysiol  2013;109:445
  102. Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat.
    Authors: Lethbridge Et al.
    Mol Pain  2012;7:e35024
  103. Pre and post synaptic NMDA effects targeting Purkinje cells in the mouse cerebellar cortex.
    Authors: Lonchamp Et al.
    PLoS One  2012;7:e30180
  104. Cerebellar globular cells receive monoaminergic excitation and monosynaptic inhibition from Purkinje cells.
    Authors: Hirono Et al.
    PLoS One  2012;7:e29663
  105. Opposing Effects of Intrinsic Conductance and Correlated Synaptic Input on V-Fluctuations during Network Activity.
    Authors: Kolind Et al.
    Front Comput Neurosci  2012;6:40
  106. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci  2012;32:8127
  107. Optimization of a GCaMP calcium indicator for neural activity imaging.
    Authors: Akerboom Et al.
    J Neurosci  2012;32:13819
  108. Intrinsic modulators of auditory thalamocortical transmission.
    Authors: Lee and Sherman
    Hear Res  2012;287:43
  109. ZD7288 enhances long-term depression at early postnatal medial perforant path-granule cell synapses.
    Authors: Guli Et al.
    Neural Plast  2012;2012:237913
  110. Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growth.
    Authors: Chacón Et al.
    Brain Res  2012;139:3200
  111. 5-hydroxytryptamine 2C receptors tonically augment synaptic currents in the nucleus tractus solitarii.
    Authors: Austgen Et al.
    Cereb Cortex  2012;108:2292
  112. Age-dependent effect of hearing loss on cortical inhibitory synapse function.
    Authors: Takesian Et al.
    J Neurophysiol  2012;107:937
  113. Synaptic responses evoked by tactile stimuli in Purkinje cells in mouse cerebellar cortex Crus II in vivo.
    Authors: Chu Et al.
    PLoS One  2011;6:e22752
  114. Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1.
    Authors: Zschenderlein Et al.
    PLoS One  2011;6:e16116
  115. GABAergic signalling in a neurogenic niche of the turtle spinal cord.
    Authors: Reali Et al.
    J Physiol  2011;589:5633
  116. Development of asymmetric inhibition underlying direction selectivity in the retina.
    Authors: Wei Et al.
    J Neurophysiol  2011;469:402
  117. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro.
    Authors: Randall Et al.
    Eur J Neurosci  2011;33:914
  118. Ovarian hormone deficiency reduces intrinsic excitability and abolishes acute estrogen sensitivity in hippocampal CA1 pyramidal neurons.
    Authors: Wu Et al.
    J Neurosci  2011;31:2638
  119. SK2 channels are neuroprotective for ischemia-induced neuronal cell death.
    Authors: Allen Et al.
    J Neurosci  2011;31:2302
  120. A diversity of synaptic filters are created by temporal summation of excitation and inhibition.
    Authors: George Et al.
    J Neurosci  2011;31:14721
  121. NMDA receptor signaling in oligodendrocyte progenitors is not required for oligodendrogenesis and myelination.
    Authors: Biase Et al.
    J Neurophysiol  2011;31:12650
  122. Endogenous brain-derived neurotrophic factor in the nucleus tractus solitarius tonically regulates synaptic and autonomic function.
    Authors: Clark Et al.
    J Neurosci  2011;31:12318
  123. Prolonged postinhibitory rebound firing in the cerebellar nuclei mediated by group I metabotropic glutamate receptor potentiation of L-type calcium currents.
    Authors: Zheng and Raman
    J Neurosci  2011;31:10283
  124. Rapid developmental maturation of neocortical FS cell intrinsic excitability.
    Authors: Goldberg Et al.
    Front Cell Neurosci  2011;21:666
  125. The SK2-long isoform directs synaptic localization and function of SK2-containing channels.
    Authors: Allen Et al.
    Nat Neurosci  2011;14:744
  126. Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract.
    Authors: Austgen Et al.
    J Neurophysiol  2011;106:1822
  127. A portable laser photostimulation and imaging microscope.
    Authors: Nikolenko Et al.
    J Neural Eng  2010;7:45001
  128. Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei.
    Authors: Person and Raman
    Neuron  2010;66:550
  129. High-Pass Filtering and Dynamic Gain Regulation Enhance Vertical Bursts Transmission along the Mossy Fiber Pathway of Cerebellum.
    Authors: Mapelli Et al.
    Nature  2010;4:14
  130. Excitability and synaptic communication within the oligodendrocyte lineage.
    Authors: Biase Et al.
    J Neurosci  2010;30:3600
  131. Orientation selectivity in rabbit retinal ganglion cells is mediated by presynaptic inhibition.
    Authors: Venkataramani and Taylor
    J Neurosci  2010;30:15664
  132. Control of CA3 output by feedforward inhibition despite developmental changes in the excitation-inhibition balance.
    Authors: Torborg Et al.
    J Neurosci  2010;30:15628
  133. Glutamine is required for persistent epileptiform activity in the disinhibited neocortical brain slice.
    Authors: Tani Et al.
    J Neurosci  2010;30:1288
  134. Substitution of 5-HT1A receptor signaling by a light-activated G protein-coupled receptor.
    Authors: Oh Et al.
    Front Neural Circuits  2010;285:30825
  135. Presynaptic 5-HT(1B) receptor-mediated serotonergic inhibition of glutamate transmission in the bed nucleus of the stria terminalis.
    Authors: Guo and Rainnie
    Neuroscience  2010;165:1390
  136. Network mechanisms of theta related neuronal activity in hippocampal CA1 pyramidal neurons.
    Authors: Losonczy Et al.
    Nat Neurosci  2010;13:967
  137. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
    Authors: Kim and Alger
    Nat Neurosci  2010;13:592
  138. Glutamate co-release at GABA/glycinergic synapses is crucial for the refinement of an inhibitory map.
    Authors: Noh Et al.
    PLoS One  2010;13:232
  139. Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.
    Authors: Barkis Et al.
    Proc Natl Acad Sci U S A  2010;107:22302
  140. ATP-dependent infra-slow (0.1 Hz) oscillations in thalamic networks.
    Authors: Lörincz Et al.
    PLoS One  2009;4:e4447
  141. Synaptic network activity induces neuronal differentiation of adult hippocampal precursor cells through BDNF signaling.
    Authors: Babu Et al.
    Front Neurosci  2009;3:49
  142. Millisecond timescale disinhibition mediates fast information transmission through an avian basal ganglia loop.
    Authors: Leblois Et al.
    J Neurosci  2009;29:15420
  143. Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in an RNA interference model of methyl-CpG-binding protein 2 deficiency.
    Authors: Wood Et al.
    Chem Senses  2009;29:12440
  144. PropF. inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
    Authors: Shiratsuchi Et al.
    Am J Physiol Cell Physiol  2009;296:C1400
  145. DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  146. Differential endocannabinoid regulation of baroreflex-evoked sympathoinhibition in normotensive versus hypertensive rats.
    Authors: Brozoski Et al.
    Auton Neurosci  2009;150:82
  147. Activity-dependent modulation of glutamatergic signaling in the developing rat dorsal horn by early tissue injury.
    Authors: Li Et al.
    Cereb Cortex  2009;102:2208
  148. Co-transmission of DA and GABA in periglomerular cells.
    Authors: Maher and Westbrook
    J Neurophysiol  2008;99:1559
  149. Effects of striatal GABA A-receptor blockade on striatal and cortical activity in monkeys.
    Authors: Darbin and Wichmann
    Front Cell Neurosci  2008;99:1294
  150. Synapse-specific adaptations to inactivity in hippocampal circuits achieve homeostatic gain control while dampening network reverberation.
    Authors: Kim and Tsien
    Neuron  2008;58:925
  151. Hearing loss prevents the maturation of GABAergic transmission in the auditory cortex.
    Authors: Kotak Et al.
    Cereb Cortex  2008;18:2098
  152. Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
    Authors: Shin Et al.
    J Neurosci  2008;105:746
  153. Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission.
    Authors: Madara and Levine
    J Neurophysiol  2008;100:3175
  154. Selective, state-dependent activation of somatostatin-expressing inhibitory interneurons in mouse neocortex.
    Authors: Fanselow Et al.
    J Neurophysiol  2008;100:2640
  155. Coupling of L-type Ca2+ channels to KV7/KCNQ channels creates a novel, activity-dependent, homeostatic intrinsic plasticity.
    Authors: Wu Et al.
    J Neurophysiol  2008;100:1897
  156. Modulation of inhibitory activity by nitric oxide in the thalamus.
    Authors: Yang
    J Neurophysiol  2007;97:3386
  157. Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
    Authors: Young and Sun
    Neuron  2007;32:783
  158. Differential effects of endocannabinoids on glutamatergic and GABAergic inputs to layer 5 pyramidal neurons.
    Authors: Fortin and Levine
    Development  2007;17:163
  159. Vesicular release of glutamate from unmyelinated axons in white matter.
    Authors: Ziskin Et al.
    Front Integr Neurosci  2007;10:321
  160. Regulation of thalamocortical patterning and synaptic maturation by NeuroD2.
    Authors: Ince-Dunn Et al.
    Neuron  2006;49:683
  161. Altered balance of glutamatergic/GABAergic synaptic input and associated changes in dendrite morphology after BDNF expression in BDNF-deficient hippocampal neurons.
    Authors: Singh Et al.
    Nature  2006;26:7189
  162. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
    Authors: Gascon Et al.
    J Neurosci  2006;26:12956
  163. Inhibitory sharpening of receptive fields contributes to whisker map plasticity in rat somatosensory cortex.
    Authors: Foeller Et al.
    J Neurophysiol  2005;94:4387
  164. Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes.
    Authors: Xiang Et al.
    J Neurophysiol  2005;93:1145
  165. PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    J Neurosci  2005;1:2
  166. HCN2 and HCN1 channels govern the regularity of autonomous pacemaking and synaptic resetting in globus pallidus neurons.
    Authors: Chan Et al.
    J Neurosci  2004;24:9921
  167. Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons.
    Authors: Huang Et al.
    J Neurosci  2004;24:4551
  168. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex.
    Authors: Bandrowski Et al.
    J Neurophysiol  2003;89:1308
  169. Localization and function of ATP and GABAA receptors expressed by nociceptors and other postnatal sensory neurons in rat.
    Authors: Labrakakis Et al.
    J Physiol  2003;549:131

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SR95531 for slice electrophysiology
By Anonymous on 01/08/2018
Application: Species: Mouse

I use SR95531 to block GABAA channels when performing slice electrophysiology.


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