Catalog # Availability Size / Price Qty
Stattic | CAS No. 19983-44-9 | STAT Inhibitors
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Description: Selective STAT3 inhibitor

Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide

Purity: ≥98%

Product Details
Citations (18)
Supplemental Products
Reviews (2)

Biological Activity

Stattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.

Technical Data

Soluble to 50 mM in DMSO
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
    Schust et al.
    Chem.Biol., 2006;13:1235

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Citations for Stattic

The citations listed below are publications that use Tocris products. Selected citations for Stattic include:

18 Citations: Showing 1 - 10

  1. Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
    Authors: Petes Et al.
    Front Immunol  2018;9:256
  2. Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.
    Authors: Fan Et al.
    Cell Death Discov  2018;4:15
  3. Interleukin-22 participates in the inflammatory process of vitiligo.
    Authors: Dong Et al.
    Oncotarget  2017;8:109161
  4. Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.
    Authors: Banerjee Et al.
    Cell Signal  2017;36:154
  5. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.
    Authors: Peda Et al.
    Dis Model Mech  2016;9:1051
  6. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9.
    Authors: Ko Et al.
    Yonsei Med J  2016;57:761
  7. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  8. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
    Authors: Okada Et al.
    PLoS One  2015;93:461
  9. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Authors: Natarajan Et al.
    Cancer Res  2014;9:e100405
  10. PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Nat Commun  2014;3:e29554


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Mitochondrial bioenergetics measurements by reagent screen
By Anonymous on 03/15/2020
Application: Species: Mouse

10 μM

PMID: 27978828

Static inhibition of STAT3 pathway
By Mark Stauffer on 01/04/2018
Application: Species: Human

Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.

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