Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Biological ActivitySmall molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
Schust et al.
Citations for Stattic
The citations listed below are publications that use Tocris products. Selected citations for Stattic include:
18 Citations: Showing 1 - 10
Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
Authors: Petes Et al.
Front Immunol 2018;9:256
Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.
Authors: Fan Et al.
Cell Death Discov 2018;4:15
Interleukin-22 participates in the inflammatory process of vitiligo.
Authors: Dong Et al.
Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.
Authors: Banerjee Et al.
Cell Signal 2017;36:154
Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.
Authors: Peda Et al.
Dis Model Mech 2016;9:1051
STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9.
Authors: Ko Et al.
Yonsei Med J 2016;57:761
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
Authors: Okada Et al.
PLoS One 2015;93:461
STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
Authors: Natarajan Et al.
Cancer Res 2014;9:e100405
PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
Authors: Shravah Et al.
Nat Commun 2014;3:e29554
Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells.
Authors: Conner Et al.
J Neurosci 2014;34:14403
Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes.
Authors: Liu Et al.
PLoS One 2013;8:e75804
Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.
Authors: Price Et al.
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
Authors: Haynes Et al.
Nat Commun 2013;4:2312
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Authors: Keasey Et al.
Cell Commun Signal 2013;11:35
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
Authors: Katz Et al.
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
Authors: Hodge Et al.
Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
Authors: Beales and Ogunwobi
J Mol Endocrinol 2009;42:305
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Reviews for Stattic
Average Rating: 4 (Based on 2 Reviews)
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Used to potentially inhibit signal transduction of the stat3 pathway in U87 cells, and was compared with other potential inhibitors in their effectivness of signal transduction when treating cells with pathway activators. It was assessed using RT-PCR for markers of pathway activation to see what inhibitor was most effective.