Stattic

  ( 14 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:2798
Chemical Name:6-Nitrobenzo[b]thiophene 1,1-dioxide
Product Details
Citations (14)
Supplemental Products
Reviews
Biological Activity
Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
Technical Data
  • M.Wt:
    211.19
  • Formula:
    C8H5NO4S
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in ethanol
  • Purity:
    >99
  • Storage:
    Store at +4°C
  • CAS No:
    19983-44-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Stattic include:

14 Citations: Showing 1 - 10
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  1. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.
    Authors: Peda Et al.
    Dis Model Mech  2016;9:1051
  2. STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9.
    Authors: Ko Et al.
    Yonsei Med J  2016;57:761
  3. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling  2016;14:32
  4. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
    Authors: Okada Et al.
    PLoS One  2015;93:461
  5. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Authors: Natarajan Et al.
    Cancer Res  2014;9:e100405
  6. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Nat Commun  2014;3:e29554
  7. Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells.
    Authors: Conner Et al.
    J Neurosci  2014;34:14403
  8. Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes.
    Authors: Liu Et al.
    PLoS One  2013;8:e75804
  9. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.
    Authors: Price Et al.
    JAKSTAT  2013;73:3441
  10. Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
    Authors: Haynes Et al.
    Nat Commun  2013;4:2312
  11. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal  2013;11:35
  12. Targeting of Rac GTPases blocks the spread of intact human breast cancer.
    Authors: Katz Et al.
    Oncotarget  2012;3:608
  13. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
    Authors: Hodge Et al.
    Blood  2012;120:3774
  14. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
    Authors: Beales and Ogunwobi
    J Mol Endocrinol  2009;42:305
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Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.

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