Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Biological ActivityStattic is a small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
Schust et al.
Citations for Stattic
The citations listed below are publications that use Tocris products. Selected citations for Stattic include:
18 Citations: Showing 1 - 10
Interleukin (IL)-6 Inhibits IL-27- and IL-30-Mediated Inflammatory Responses in Human Monocytes.
Authors: Petes Et al.
Front Immunol 2018;9:256
Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells.
Authors: Fan Et al.
Cell Death Discov 2018;4:15
Interleukin-22 participates in the inflammatory process of vitiligo.
Authors: Dong Et al.
Reduced FAK-STAT3 signaling contributes to ER stress-induced mitochondrial dysfunction and death in endothelial cells.
Authors: Banerjee Et al.
Cell Signal 2017;36:154
Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease.
Authors: Peda Et al.
Dis Model Mech 2016;9:1051
STAT3 and ERK Signaling Pathways Are Implicated in the Invasion Activity by Oncostatin M through Induction of Matrix Metalloproteinases 2 and 9.
Authors: Ko Et al.
Yonsei Med J 2016;57:761
Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
Cell Communication and Signaling 2016;14:32
STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
Authors: Okada Et al.
PLoS One 2015;93:461
STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
Authors: Natarajan Et al.
Cancer Res 2014;9:e100405
PropF. mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
Authors: Shravah Et al.
Nat Commun 2014;3:e29554
Repressing notch signaling and expressing TNFα are sufficient to mimic retinal regeneration by inducing Müller glial proliferation to generate committed progenitor cells.
Authors: Conner Et al.
J Neurosci 2014;34:14403
Stat3 inhibition attenuates mechanical allodynia through transcriptional regulation of chemokine expression in spinal astrocytes.
Authors: Liu Et al.
PLoS One 2013;8:e75804
Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.
Authors: Price Et al.
Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
Authors: Haynes Et al.
Nat Commun 2013;4:2312
Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
Authors: Keasey Et al.
Cell Commun Signal 2013;11:35
Targeting of Rac GTPases blocks the spread of intact human breast cancer.
Authors: Katz Et al.
IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
Authors: Hodge Et al.
Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
Authors: Beales and Ogunwobi
J Mol Endocrinol 2009;42:305
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