Catalog Number: 2798
Chemical Name: 6-Nitrobenzo[b]thiophene 1,1-dioxide
Biological Activity
Small molecule inhibitor of STAT3. Inhibits binding of tyrosine-phosphorylated peptide motifs to STAT3 SH2 domain and inhibits STAT3 activation, dimerization and nuclear translocation. Displays selectivity over STAT1, STAT5, c-Myc/Max, Jun/Jun and Lck. Induces apoptosis in STAT3-dependent cancer cell lines.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO and to 5 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization.
    Schust et al.
    Chem.Biol., 2006;13:1235

The citations listed below are publications that use Tocris products. Selected citations for Stattic include:

10 Citations: Showing 1 - 10
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  1. Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3.
    Authors: Visavadiya
    Cell Communication and Signaling 2016;14:32
  2. STAT3 signaling contributes to the high effector activities of interleukin-15-derived dendritic cells.
    Authors: Okada Et al.
    PLoS One 2015;93:461
  3. STAT3 modulation to enhance motor neuron differentiation in human neural stem cells.
    Authors: Natarajan Et al.
    Cancer Res 2014;9:e100405
  4. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT.
    Authors: Shravah Et al.
    Nat Commun 2014;3:e29554
  5. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.
    Authors: Price Et al.
    JAKSTAT 2013;73:3441
  6. Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.
    Authors: Haynes Et al.
    Nat Commun 2013;4:2312
  7. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression.
    Authors: Keasey Et al.
    Cell Commun Signal 2013;11:35
  8. Targeting of Rac GTPases blocks the spread of intact human breast cancer.
    Authors: Katz Et al.
    Oncotarget 2012;3:608
  9. IL-21 in the bone marrow microenvironment contributes to IgM secretion and proliferation of malignant cells in Waldenstrom macroglobulinemia.
    Authors: Hodge Et al.
    Blood 2012;120:3774
  10. Glycine-extended gastrin inhibits apoptosis in Barrett's oesophageal and oesophageal adenocarcinoma cells through JAK2/STAT3 activation.
    Authors: Beales and Ogunwobi
    J Mol Endocrinol 2009;42:305

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