STO-609 acetate

Tocris Bioscience | Catalog # 1551

Selective CaM kinase kinase inhibitor
Tocris Bioscience

Key Product Details

Description

Selective CaM kinase kinase inhibitor
View all Calcium Binding Protein Modulator Inhibitors »

Product Description

STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of STO-609 acetate is reviewed on the Chemical Probes website.

Product Specifications for STO-609 acetate

Molecular Weight

374.35

Formula

C19H10N2O3.C2H4O2

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate

CAS Number

1173022-21-3

PubChem ID

16760660

InChI Key

WNRSTFUVBWNELX-UHFFFAOYSA-N

SMILES

CC(O)=O.OC(=O)C1=C2C=CC=C3C(=O)N4C5=CC=CC=C5N=C4C(C=C1)=C23

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
100mM NaOH 16.85 45
DMSO 3.74 10 with sonication

Preparing Stock Solutions for STO-609 acetate

The following data is based on the product molecular weight 374.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.45 mM 5.94 mL 29.68 mL 59.36 mL
2.25 mM 1.19 mL 5.94 mL 11.87 mL
4.5 mM 0.59 mL 2.97 mL 5.94 mL
22.5 mM 0.12 mL 0.59 mL 1.19 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

Product Documents for STO-609 acetate

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for STO-609 acetate

For research use only

Citations for STO-609 acetate

Customer Reviews for STO-609 acetate (2)

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  • Use in smooth muscle
    Name: Mohammad Alqudah
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle
    Verified Customer | Posted 10/19/2022
    10 uM of STO-609 30 min before challenging smooth muscle strips with contractile agonist in an organ bath. Good inhibition at 10 min the inhibition was minimal.
    STO-609 acetate 1551
  • Good STO-609 acetate
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Smooth muscle cell
    Verified Customer | Posted 12/05/2021
    20 microM STO-609 acetate was used to test its effect on MCP1 induced SMC migration.
    STO-609 acetate 1551

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