Catalog Number: 1551
Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Biological Activity
Selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 45 mM in 100mM NaOH and to 10 mM in DMSO with sonication
  • Purity:
  • Storage:
    Desiccate at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase.
    Tokumitsu et al.
    J.Biol.Chem., 2002;277:15813

The citations listed below are publications that use Tocris products. Selected citations for STO-609 acetate include:

Showing Results 1 - 10 of 29

  1. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization.
    Authors: Horigane Et al.
    Proc Natl Acad Sci U S A
  2. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    Biochem Biophys Res Commun
  3. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    Mol Brain
  4. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
    Authors: Zhu Et al.
    J Exp Med
  5. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Mol Brain
  6. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.
    Authors: Li Et al.
    Nat Commun
  7. Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.
    Authors: Iseli Et al.
    PLoS One
  8. Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
    Authors: Parker Et al.
    Sci Transl Med
  9. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Neurosci
  10. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem
  11. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
    Authors: Kawashima Et al.
    J Immunol
  12. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci
  13. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci
  14. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
    Authors: Ashpole Et al.
    J Biol Chem
  15. A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
    Authors: Karacosta Et al.
    J Biol Chem
  16. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
    Authors: Terry Et al.
    Biochem Biophys Res Commun
  17. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.
    Authors: Fu Et al.
    Proc Natl Acad Sci U S A
  18. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
    Authors: Fogarty Et al.
    Biochem J
  19. The Bα and Bδ regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
    Authors: Reece Et al.
    J Biol Chem
  20. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells.
    Authors: Soltoff and Hedden
    Am J Physiol Cell Physiol
  21. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
    Authors: Guire Et al.
    Mol Cell
  22. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    PLoS One
  23. AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
    Authors: Reihill Et al.
    Proc Natl Acad Sci U S A
  24. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
    Authors: Göransson Et al.
    J Biol Chem
  25. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.
    Authors: Sanders Et al.
    Mucosal Immunol
  26. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β and Bcl-2.
    Authors: Høyer-Hansen Et al.
  27. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.
    Authors: Tamás Et al.
    Biochem Biophys Res Commun
  28. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
    Authors: Hawley Et al.
    Cell Metab
  29. Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.
    Authors: Guest Et al.
    PLoS One
Expand to show all
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