Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Biological ActivitySelective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase.
Tokumitsu et al.
Citations for STO-609 acetate
The citations listed below are publications that use Tocris products. Selected citations for STO-609 acetate include:
34 Citations: Showing 1 - 10
TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.
Authors: Zhang Et al.
Sci Rep 2017;7:3158
Pharmacological inhibition of CaMKK2 with the selective antagonist STO-609 regresses NAFLD.
Authors: York Et al.
Sci Rep 2017;7:11793
Direct versus indirect actions of ghrelin on hypothalamic NPY neurons.
PLoS One 2017;12(9):e0184261
Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization.
Authors: Horigane Et al.
Proc Natl Acad Sci U S A 2016;9:8
Dissection and integration of the autophagy signaling network initiated by bluetongue virus infection: crucial candidates ERK1/2, Akt and AMPK.
Authors: Lv Et al.
Sci Rep 2016;6:23130
N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
Authors: Lee Et al.
Biochem Biophys Res Commun 2015;8:4
Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
Authors: Cohen Et al.
Mol Brain 2015;460:88
Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
Authors: Zhu Et al.
J Exp Med 2015;194:584
The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
Authors: Obba Et al.
Mol Brain 2015;11:1114
Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.
Authors: Li Et al.
Nat Commun 2014;5:5601
Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.
Authors: Iseli Et al.
PLoS One 2013;8:e62309
Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
Authors: Parker Et al.
Sci Transl Med 2013;5:182ra53
Calcium release-dependent actin flow in the leading process mediates axophilic migration.
Authors: Hutchins Et al.
J Neurosci 2013;33:11361
Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
Authors: Kim Et al.
J Biol Chem 2013;288:22693
AMPKα1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration.
Authors: Mounier Et al.
Cell Metab 2013;18:251
Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
Authors: Kawashima Et al.
J Immunol 2012;7:e36335
Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
Authors: Fortin Et al.
J Neurosci 2012;32:8127
Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
Authors: Gaamouch Et al.
J Neurosci 2012;32:10767
Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
Authors: Ashpole Et al.
J Biol Chem 2012;287:8495
A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
Authors: Karacosta Et al.
J Biol Chem 2012;287:24832
Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
Authors: Terry Et al.
Biochem Biophys Res Commun 2012;109:3071
Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.
Authors: Fu Et al.
Proc Natl Acad Sci U S A 2011;108:1403
Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
Authors: Fogarty Et al.
Biochem J 2010;426:109
The Bα and Bδ regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
Authors: Reece Et al.
J Biol Chem 2009;386:582
Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.
Authors: Guest Et al.
PLoS One 2008;3:e1606
Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells.
Authors: Soltoff and Hedden
Am J Physiol Cell Physiol 2008;295:C590
Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
Authors: Guire Et al.
Mol Cell 2008;28:6000
An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
Authors: Wayman Et al.
PLoS One 2008;105:9093
AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
Authors: Reihill Et al.
Proc Natl Acad Sci U S A 2007;354:1084
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
Authors: Göransson Et al.
J Biol Chem 2007;282:32549
Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.
Authors: Sanders Et al.
Mucosal Immunol 2007;282:32539
Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β and Bcl-2.
Authors: Høyer-Hansen Et al.
Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.
Authors: Tamás Et al.
Biochem Biophys Res Commun 2006;203:1665
Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
Authors: Hawley Et al.
Cell Metab 2005;2:9
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