Catalog Number: 1551
Chemical Name: 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate
Biological Activity
Selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively); competes for the ATP-binding site. Displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK.
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of STO-609 acetate is reviewed on the Chemical Probes website.
Technical Data
  • M.Wt:
    374.35
  • Formula:
    C19H10N2O3.C2H4O2
  • Solubility:
    Soluble to 45 mM in 100mM NaOH and to 10 mM in DMSO with sonication
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
  • CAS No:
    1173022-21-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. STO-609, a specific inhibitor of the Ca2+/calmodulin-dependent protein kinase kinase.
    Tokumitsu et al.
    J.Biol.Chem., 2002;277:15813
Citations:

The citations listed below are publications that use Tocris products. Selected citations for STO-609 acetate include:

29 Citations: Showing 1 - 10
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  1. Ca2+/calmodulin-dependent kinase kinase alpha is expressed by monocytic cells and regulates the activation profile.
    Authors: Guest Et al.
    PLoS One ;3:e1606
  2. Facilitation of axon outgrowth via a Wnt5a-CaMKK-CaMKIα pathway during neuronal polarization.
    Authors: Horigane Et al.
    Proc Natl Acad Sci U S A 2016;9:8
  3. N-methyl-D-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
    Authors: Lee Et al.
    Biochem Biophys Res Commun 2015;8:4
  4. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus.
    Authors: Cohen Et al.
    Mol Brain 2015;460:88
  5. Adenosine 5'-monophosphate-activated protein kinase regulates IL-10-mediated anti-inflammatory signaling pathways in macrophages.
    Authors: Zhu Et al.
    J Exp Med 2015;194:584
  6. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML.
    Authors: Obba Et al.
    Mol Brain 2015;11:1114
  7. Cell cycle-linked MeCP2 phosphorylation modulates adult neurogenesis involving the Notch signalling pathway.
    Authors: Li Et al.
    Nat Commun 2014;5:5601
  8. Activation of AMPK by bitter melon triterpenoids involves CaMKKβ.
    Authors: Iseli Et al.
    PLoS One 2013;8:e62309
  9. Rapamycin prevents seizures after depletion of STRADA in a rare neurodevelopmental disorder.
    Authors: Parker Et al.
    Sci Transl Med 2013;5:182ra53
  10. Calcium release-dependent actin flow in the leading process mediates axophilic migration.
    Authors: Hutchins Et al.
    J Neurosci 2013;33:11361
  11. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem 2013;288:22693
  12. Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia.
    Authors: Kawashima Et al.
    J Immunol 2012;7:e36335
  13. Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors.
    Authors: Fortin Et al.
    J Neurosci 2012;32:8127
  14. Interaction between αCaMKII and GluN2B controls ERK-dependent plasticity.
    Authors: Gaamouch Et al.
    J Neurosci 2012;32:10767
  15. Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability.
    Authors: Ashpole Et al.
    J Biol Chem 2012;287:8495
  16. A regulatory feedback loop between Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) and the androgen receptor in prostate cancer progression.
    Authors: Karacosta Et al.
    J Biol Chem 2012;287:24832
  17. Human kinome profiling identifies a requirement for AMP-activated protein kinase during human cytomegalovirus infection.
    Authors: Terry Et al.
    Biochem Biophys Res Commun 2012;109:3071
  18. Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway.
    Authors: Fu Et al.
    Proc Natl Acad Sci U S A 2011;108:1403
  19. Calmodulin-dependent protein kinase kinase-beta activates AMPK without forming a stable complex: synergistic effects of Ca2+ and AMP.
    Authors: Fogarty Et al.
    Biochem J 2010;426:109
  20. The Bα and Bδ regulatory subunits of PP2A are necessary for assembly of the CaMKIV.PP2A signaling complex.
    Authors: Reece Et al.
    J Biol Chem 2009;386:582
  21. Regulation of ERK1/2 by ouabain and Na-K-ATPase-dependent energy utilization and AMPK activation in parotid acinar cells.
    Authors: Soltoff and Hedden
    Am J Physiol Cell Physiol 2008;295:C590
  22. Recruitment of calcium-permeable AMPA receptors during synaptic potentiation is regulated by CaM-kinase I.
    Authors: Guire Et al.
    Mol Cell 2008;28:6000
  23. An activity-regulated microRNA controls dendritic plasticity by down-regulating p250GAP.
    Authors: Wayman Et al.
    PLoS One 2008;105:9093
  24. AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.
    Authors: Reihill Et al.
    Proc Natl Acad Sci U S A 2007;354:1084
  25. Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase.
    Authors: Göransson Et al.
    J Biol Chem 2007;282:32549
  26. Defining the mechanism of activation of AMP-activated protein kinase by the small molecule A-769662, a member of the thienopyridone family.
    Authors: Sanders Et al.
    Mucosal Immunol 2007;282:32539
  27. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-β and Bcl-2.
    Authors: Høyer-Hansen Et al.
    Autophagy 2007;25:193
  28. Regulation of the energy sensor AMP-activated protein kinase by antigen receptor and Ca2+ in T lymphocytes.
    Authors: Tamás Et al.
    Biochem Biophys Res Commun 2006;203:1665
  29. Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.
    Authors: Hawley Et al.
    Cell Metab 2005;2:9
Expand to show all 29 Citations

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