Chemical Name: (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
Biological ActivitySelective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Sattler et al.
Cancer Res., 2003;63:5462
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth.
Wang et al.
Mol.Cancer Ther., 2003;2:1085
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
Seiwert et al.
Cancer Res., 2009;69:3021
Citations for SU 11274
The citations listed below are publications that use Tocris products. Selected citations for SU 11274 include:
5 Citations: Showing 1 - 5
YangZheng XiaoJi exerts anti-tumour growth effects by antagonising the effects of HGF and its receptor, cMET, in human lung cancer cells.
Authors: Jiang Et al.
Differential regulation of c-Met signaling pathways for synovial cell function.
Authors: Shibasaki Et al.
J Transl Med 2014;3:554
Dissecting the role of human embryonic stem cell-derived mesenchymal cells in human umbilical vein endothelial cell network stabilization in three-dimensional environments.
Authors: Boyd Et al.
Tissue Eng Part A 2013;19:211
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.
Authors: Sullivan Et al.
Disturbance of Ca2+ homeostasis converts pro-Met into non-canonical tyrosine kinase p190MetNC in response to endoplasmic reticulum stress in MHCC97 cells.
Authors: Dai Et al.
J Biol Chem 2012;287:14586
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