Selective inhibitor of MET tyrosine kinase activity (IC50
= 0.01 μ
M in vitro
). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro
and tumor angiogenesis in vivo
Soluble to 50 mM in DMSO
Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
A novel small molecule Met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase.
Sattler et al.
Cancer Res., 2003;63:5462
Potent and selective inhibitors of the Met [hepatocyte growth factor/scatter factor (HGF/SF) receptor] tyrosine kinase block HGF/SF-induced tumor cell growth.
Wang et al.
Mol.Cancer Ther., 2003;2:1085
The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma.
Seiwert et al.
Cancer Res., 2009;69:3021
The citations listed below are publications that use Tocris products. Selected citations for SU 11274 include:
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