SU 11274

  ( 5 citations )    
Product Datasheet
Catalog Number:4101
Chemical Name:(3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
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Citations (5)
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Biological Activity
Selective inhibitor of MET tyrosine kinase activity (IC50 = 0.01 μM in vitro). Reduces cell growth in a dose-dependent manner; induces cell cycle arrest and apoptosis. Abrogates cell motility and migration in vitro and tumor angiogenesis in vivo.
Technical Data
  • M.Wt:
    568.09
  • Formula:
    C28H30ClN5O4S
  • Solubility:
    Soluble to 50 mM in DMSO
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    658084-23-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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