Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50
values are 0.02, 0.03, 0.51 and > 100 μ
M at VEGFR2, FGFR1, PDGFRβ
and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro
and in vivo
. Also attenuates integrin β
4-induced differentiation of neural stem cells.
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All Tocris products are intended for laboratory research use only.
Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.
Paterson et al.
FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.
Tanaka et al.
Neural stem cell differentiation is mediated by integrin beta4 in vitro.
Su et al.
Int.J.Biochem.Cell Biol., 2009;41:916
Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases.
Sun et al.
The citations listed below are publications that use Tocris products. Selected citations for SU 5402 include:
Showing Results 1 - 10 of 11