Catalog Number: 3300
Chemical Name: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid
Biological Activity
Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells.
Technical Data
  • M.Wt:
    296.32
  • Formula:
    C17H16N2O3
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >95%
  • Storage:
    Store at -20°C
  • CAS No:
    215543-92-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma.
    Paterson et al.
    Br.J.Haematol., 2004;124:595
  2. FGF-induced vesicular release of sonic hedgehog and retinoic acid in leftward nodal flow is critical for left-right determination.
    Tanaka et al.
    Nature, 2005;435:172
  3. Neural stem cell differentiation is mediated by integrin beta4 in vitro.
    Su et al.
    Int.J.Biochem.Cell Biol., 2009;41:916
  4. Design, synthesis and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl]indolin-2-ones as inhibitors of VEGF, FGF and PDGF receptor tyrosine kinases.
    Sun et al.
    J.Med.Chem., 1999;42:5120
Citations:

The citations listed below are publications that use Tocris products. Selected citations for SU 5402 include:

12 Citations: Showing 1 - 10
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  1. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells.
    Authors: Rodrigues
    PNAS 2017;114(12):3139
  2. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.
    Authors: Benzina Et al.
    PLoS One 2015;72:3559
  3. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.
    Authors: Cunningham Et al.
    PLoS One 2015;10:e0137894
  4. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus.
    Authors: Dean Et al.
    Stem Cell Res Ther 2014;9:20
  5. FGF signaling is required for brain left-right asymmetry and brain midline formation.
    Authors: Neugebauer and Yost
    Dev Biol 2014;386:123
  6. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation.
    Authors: Dai Et al.
    Cell Death Differ 2014;21:568
  7. p38 MAPK signaling underlies a cell-autonomous loss of stem cell self-renewal in skeletal muscle of aged mice.
    Authors: Bernet Et al.
    Dev Biol 2014;20:265
  8. Anteroposterior and dorsoventral patterning are coordinated by an identical patterning clock.
    Authors: Hashiguchi and Mullins
    Development 2013;140:1970
  9. The existence of FGFR1-5-HT1A receptor heterocomplexes in midbrain 5-HT neurons of the rat: relevance for neuroplasticity.
    Authors: Borroto-Escuela Et al.
    J Neurosci 2012;32:6295
  10. Suppression of Bmp4 signaling by the zinc-finger repressors Osr1 and Osr2 is required for Wnt/β-catenin-mediated lung specification in Xenopus.
    Authors: Rankin Et al.
    Cell Mol Life Sci 2012;139:3010
  11. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.
    Authors: Tan Et al.
    Nat Med 2011;6:e17124
  12. FGF8 signaling is chemotactic for cardiac neural crest cells.
    Authors: Sato Et al.
    Neural Dev 2011;354:18
Expand to show all 12 Citations

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