SU 5402

Catalog # Availability Size / Price Qty
3300/1
SU 5402 | CAS No. 215543-92-3 | FGF Receptor Inhibitors
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Description: Potent FGFR and VEGFR inhibitor

Chemical Name: 2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid

Purity: ≥95%

Product Details
Citations (18)
Supplemental Products
Reviews

Biological Activity

Potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor (IC50 values are 0.02, 0.03, 0.51 and > 100 μM at VEGFR2, FGFR1, PDGFRβ and EGFR respectively). Inhibits embryonic left-right determination and exhibits potent anticancer activity in vitro and in vivo. Also attenuates integrin β4-induced differentiation of neural stem cells. Supports mESC self-renewal.

Technical Data

M.Wt:
296.32
Formula:
C17H16N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
215543-92-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for SU 5402

The citations listed below are publications that use Tocris products. Selected citations for SU 5402 include:

18 Citations: Showing 1 - 10

  1. Hey2 regulates the size of the cardiac progenitor pool during vertebrate heart development.
    Authors: Gibb Et al.
    Development  2018;145
  2. Chemical inhibition reveals differential requirements of signaling pathways in krasV12- and Myc-induced liver tumors in transgenic zebrafish.
    Authors: Yan Et al.
    Sci Rep  2017;7:45796
  3. Establishment of mouse expanded potential stem cells.
    Authors: Yang Et al.
    Nature  2017;550:393
  4. Integration of Shh and Fgf signaling in controlling Hox gene expression in cultured limb cells.
    Authors: Rodrigues
    PNAS  2017;114(12):3139
  5. FGF1 Mediates Overnutrition-Induced Compensatory β-Cell Differentiation.
    Authors: Li Et al.
    Diabetes  2016;65:96
  6. A kinome-targeted RNAi-based screen links FGF signaling to H2AX phosphorylation in response to radiation.
    Authors: Benzina Et al.
    PLoS One  2015;72:3559
  7. Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis.
    Authors: Cunningham Et al.
    PLoS One  2015;10:e0137894
  8. Dbx1b defines the dorsal habenular progenitor domain in the zebrafish epithalamus.
    Authors: Dean Et al.
    Stem Cell Res Ther  2014;9:20
  9. FGF signaling is required for brain left-right asymmetry and brain midline formation.
    Authors: Neugebauer and Yost
    Dev Biol  2014;386:123
  10. Calcium deficiency-induced and TRP channel-regulated IGF1R-PI3K-Akt signaling regulates abnormal epithelial cell proliferation.
    Authors: Dai Et al.
    Cell Death Differ  2014;21:568

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