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Sulfisoxazole

Catalog #: 0731 Datasheet / COA / SDS

Discontinued Product

0731 has been discontinued.
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Sulfisoxazole | CAS No. 127-69-5 | Endothelin ETA Receptor Antagonists
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Description: Endothelin ETA antagonist

Chemical Name: 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide

Purity: ≥99%

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Biological Activity

Sulfisoxazole is a selective ETA endothelin receptor antagonist (IC50 values are 600 and 2200 nM for ETA and ETB receptors respectively).

Technical Data

M.Wt:
267.3
Formula:
C11H13N3O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
127-69-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening.
    Chan et al.
    Biochem.Biophys.Res.Commun., 1994;201:228

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