Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Biological ActivityProdrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.
The technical data provided above is for guidance only.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Sulindac and its derivatives: a novel class of anticancer agents.
Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.
Taylor et al.
Cancer Res., 2000;60:6607
Chemical and biological studies on indomethacin, sul. and their analogs.
Shen and Winter
Adv.Drug Res., 1977;12:90
Citation for Sulindac
The citations listed below are publications that use Tocris products. Selected citations for Sulindac include:
1 Citation: Showing 1 - 1
Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
Authors: Hagen Et al.
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