Catalog Number: 1707
Chemical Name: (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
Biological Activity
Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo. Widely used anti-inflammatory agent.
Technical Data
  • M.Wt:
    356.41
  • Formula:
    C20H17FO3S
  • Solubility:
    Soluble to 100 mM in DMSO and to 25 mM in ethanol
  • Purity:
    >99%
  • Storage:
    Store at RT
  • CAS No:
    38194-50-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Sulindac and its derivatives: a novel class of anticancer agents.
    Haanen
    Curr.Opin.Investig.Drugs, 2001;2:677
  2. Chemical and biological studies on indomethacin, sulindac and their analogs.
    Shen and Winter
    Adv.Drug Res., 1977;12:90
  3. Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.
    Taylor et al.
    Cancer Res., 2000;60:6607
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Sulindac include:

1 Citations: Showing 1 - 1

  1. Comparative Multi-Donor Study of IFNγ Secretion and Expression by Human PBMCs Using ELISPOT Side-by-Side with ELISA and Flow Cytometry Assays.
    Authors: Hagen Et al.
    Cells 2015;4:84

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