Prodrug. Metabolizes to sulindac sulfide, a cyclooxgenase inhibitor that represses ras signaling, and sulindac sulfone, an antitumor agent, following oral administration in vivo
. Widely used anti-inflammatory agent.
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All Tocris products are intended for laboratory research use only.
Sulindac and its derivatives: a novel class of anticancer agents.
Chemical and biological studies on indomethacin, sulindac and their analogs.
Shen and Winter
Adv.Drug Res., 1977;12:90
Sulindac sulfone inhibits K-ras-dependent cyclooxygenase-2 expression in human colon cancer cells.
Taylor et al.
Cancer Res., 2000;60:6607
The citations listed below are publications that use Tocris products. Selected citations for Sulindac include:
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