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Superoxide Dismutase Assay Kit

Catalog #: 7500-100-KB
19 Citations Datasheet / COA / SDS

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7500-100-KB has been discontinued.
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Citations (19)
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Superoxide Dismutase Assay Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
The product requires storage at -20 to -70 °C and 2 - 8 °C.  Consult the product insert for specific storage temperatures. Do not use past expiration date.
Species
Multi-Species

Product Datasheets

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COA

Background: SOD (Superoxide Dismutase)

Superoxide Dismutases, originally identified as Indophenoloxidases (IPOs), are enzymes that catalyze the conversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Three mammalian isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SODs are typically soluble secreted or cytosolic proteins, but are also found in the mitochondria and extracellular matrix.

Any of three metals, manganese, iron, or copper, may be used in the active site of SOD and are indicative of cellular localization.MnSOD (SOD2) is found in the mitochondria of both prokaryotes and ukaryotes, whereas the cytosol of eukaryotes and prokaryotic organisms contains Cu/ZnSOD (SOD1) and FeSOD, respectively.

There have been several mutations identified in the Cu/ZnSOD (SOD1) gene in amyotrophic lateral sclerosis (ALS) patients, possibly suggesting a role for free radicals in this disease process. The mechanism of motor neuron degeneration that occurs in ALS, however, is unclear at this time. Several hypotheses have been explored for the role of mutant SOD1 and convincing evidence for the involvement of apoptosis has been presented, as well.

Long Name
Superoxide Dismutase
Alternate Names
SOD

Citations for Superoxide Dismutase Assay Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Fxyd5 activates the NF?kappaB pathway and is involved in chondrocytes inflammation and extracellular matrix degradation
    Authors: L Song, X Li, Q Sun, Y Zhao
    Molecular Medicine Reports, 2022-02-22;25(4):.  2022-02-22
  2. Protective effects of hydrogen?rich saline against experimental diabetic peripheral neuropathy via activation of the mitochondrial ATP?sensitive potassium channel channels in rats
    Authors: Y Jiao, Y Yu, B Li, X Gu, K Xie, G Wang, Y Yu
    Mol Med Rep, 2019-11-05;21(1):282-290.  2019-11-05
  3. Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans
    Authors: L Bergandi, OA Skorokhod, R La Grotta, E Schwarzer, R Nuzzi
    J Ophthalmol, 2019-10-30;2019(0):7231015.  2019-10-30
  4. SOD2 Mediates Curcumin-Induced Protection against Oxygen-Glucose Deprivation/Reoxygenation Injury in HT22 Cells
    Authors: Y Wang, Y Zhang, L Yang, J Yuan, J Jia, S Yang
    Evid Based Complement Alternat Med, 2019-09-29;2019(0):2160642.  2019-09-29
  5. Calreticulin Ins5 and Del52 mutations impair unfolded protein and oxidative stress responses in K562 cells expressing CALR mutants
    Authors: S Salati, E Genovese, C Carretta, R Zini, N Bartalucci, Z Prudente, V Pennucci, S Ruberti, C Rossi, S Rontauroli, E Enzo, L Calabresi, M Balliu, C Mannarelli, E Bianchi, P Guglielmel, E Tagliafico, AM Vannucchi, R Manfredini
    Sci Rep, 2019-07-22;9(1):10558.  2019-07-22
  6. Ginkgo biloba extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway
    Authors: XJ Chen, SM Ren, JZ Dong, CG Qiu, YW Chen, HL Tao
    Drug Des Devel Ther, 2019-02-13;13(0):647-655.  2019-02-13
  7. Anti-Hyperuricemic Effect of 2-Hydroxy-4-methoxy-benzophenone-5-sulfonic Acid in Hyperuricemic Mice through XOD
    Authors: T Yong, D Li, M Li, D Liang, X Diao, C Deng, S Chen, Y Xie, D Chen, D Zuo
    Molecules, 2018-10-17;23(10):.  2018-10-17
  8. Suppression of human arthritis synovial fibroblasts inflammation using dexamethasone-carbon nanotubes via increasing caveolin-dependent endocytosis and recovering mitochondrial membrane potential
    Authors: YK Lee, SW Kim, JY Park, WC Kang, YJ Kang, D Khang
    Int J Nanomedicine, 2017-08-10;12(0):5761-5779.  2017-08-10
  9. Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro.
    Authors: Senathilake K, Karunanayake E, Samarakoon S, Tennekoon K, de Silva E, Adhikari A
    Exp Parasitol, 2017-03-27;177(0):13-21.  2017-03-27
  10. Rosiglitazone causes cardiotoxicity via peroxisome proliferator-activated receptor gamma-independent mitochondrial oxidative stress in mouse hearts.
    Authors: He H, Tao H, Xiong H, Duan S, McGowan F, Mortensen R, Balschi J
    Toxicol Sci, 2014-01-21;138(2):468-81.  2014-01-21
  11. Protective activity of a novel resveratrol analogue, HS-1793, against DNA damage in 137Cs-irradiated CHO-K1 cells.
    Authors: Jeong M, Yang K, Jeong D, Lee C, Oh S, Jeong S, Lee K, Jo Y, Jo W
    J Radiat Res, 2014-01-07;55(3):464-75.  2014-01-07
  12. Genetic disruption of SOD1 gene causes glucose intolerance and impairs beta-cell function.
    Authors: Muscogiuri G, Salmon A, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick R, Reyna S, Weir G, Defronzo R, Van Remmen H, Musi N
    Diabetes, 2013-09-05;62(12):4201-7.  2013-09-05
  13. CyclinB1/Cdk1 phosphorylates mitochondrial antioxidant MnSOD in cell adaptive response to radiation stress.
    Authors: Candas D, Fan M, Nantajit D, Vaughan A, Murley J, Woloschak G, Grdina D, Li J
    J Mol Cell Biol, 2012-12-12;5(3):166-75.  2012-12-12
  14. Pulmonary Biocompatibility Assessment of Inhaled Single-wall and Multiwall Carbon Nanotubes in BALB/c Mice.
    Authors: Ravichandran P, Baluchamy S, Gopikrishnan R, Biradar S, Ramesh V, Goornavar V, Thomas R, Wilson BL, Jeffers R, Hall JC, Ramesh GT
    J. Biol. Chem., 2011-06-24;286(34):29725-33.  2011-06-24
  15. XIAP regulates intracellular ROS by enhancing antioxidant gene expression.
    Authors: Resch U, Schichl YM, Sattler S, de Martin R
    Biochem. Biophys. Res. Commun., 2008-08-08;375(1):156-61.  2008-08-08
  16. Impaired response to oxidative stress in senescent cells may lead to accumulation of DNA damage in mesothelial cells from aged donors.
    Authors: Ksiazek K, Piatek K, Witowski J
    Biochem. Biophys. Res. Commun., 2008-06-17;373(2):335-9.  2008-06-17
  17. Inhibition of cadmium-induced oxidative injury in rat primary astrocytes by the addition of antioxidants and the reduction of intracellular calcium.
    Authors: Yang CS, Tzou BC, Liu YP, Tsai MJ, Shyue SK, Tzeng SF
    J. Cell. Biochem., 2008-02-15;103(3):825-34.  2008-02-15
  18. Antioxidant enzyme gene delivery to protect from HIV-1 gp120-induced neuronal apoptosis.
    Authors: Agrawal L, Louboutin JP, Reyes BA, Van Bockstaele EJ, Strayer DS
    Gene Ther., 2006-07-27;13(23):1645-56.  2006-07-27
  19. Oxidized SOD1 alters proteasome activities in vitro and in the cortex of SOD1 overexpressing mice.
    Authors: Le Pecheur M, Bourdon E, Paly E, Farout L, Friguet B, London J
    FEBS Lett., 2005-07-04;579(17):3613-8.  2005-07-04

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