Synaptophysin Antibody (SP11)

Novus Biologicals | Catalog # NB120-16659

Novus Biologicals
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Human, Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Cited:

Immunohistochemistry-Paraffin, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Rabbit IgG Clone # SP11
View all Synaptophysin Primary Antibodies »

Product Specifications

Immunogen

Synthetic peptide of human Synaptophysin.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 29420126). Not yet tested in other species.

Localization

Cytoplasmic

Marker

Pre-synaptic marker

Specificity

This antibody recognizes a protein of 38kDa, identified as synaptophysin. It labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth's cells in the gastrointestinal tract and gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Synaptophysin Antibody (SP11)

Immunohistochemistry-Paraffin: Synaptophysin Antibody (SP11) [NB120-16659]

Immunohistochemistry-Paraffin: Synaptophysin Antibody (SP11) [NB120-16659]

Immunohistochemistry-Paraffin: Synaptophysin Antibody (SP11) [NB120-16659] - Formalin fixed paraffin embedded human pancreas stained with Synaptophysin antibody (NB120-16659).

Applications for Synaptophysin Antibody (SP11)

Application
Recommended Usage

Immunohistochemistry

1:25-1:50

Immunohistochemistry-Paraffin

1:25-1:50
Application Notes
IHC-P: recommended incubation time of 30-60 min at RT. Use in Immunocytochemistry/immunofluorescence reported in scientific literature (PMID 25483960).

Formulation, Preparation, and Storage

Purification

Tissue culture supernatant

Formulation

Tissue culture supernatant

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Synaptophysin

Synaptophysin is a 38 kDa glycoprotein present in the membrane of neuronal presynaptic vesicles in brain, spinal cord, retina, vesicles of adrenal medulla, neuromuscular junctions, and endocrine cells. It is also expressed by neuroendocrine cells throughout the body, both normal and neoplastic. Synaptophysin is a useful marker for the identification of normal neuroendocrine cells and neuroendocrine neoplasms. This antibody reacts with neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, and gastointestinal mucosa. It also reacts with a wide spectrum of neuroendocrine neoplasms of neural type including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non chromaffin paragangliomas.

Alternate Names

SYP

Gene Symbol

SYP

Additional Synaptophysin Products

Product Documents for Synaptophysin Antibody (SP11)

Certificate of Analysis

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Product Specific Notices for Synaptophysin Antibody (SP11)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations for Synaptophysin Antibody (SP11)

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Protocols

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FAQs

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