Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Frozen, Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free
View all Syntaxin-BP1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic Peptide: V(58) E D I N K R R E P I P S(70)

Reactivity Notes

Expected cross-reactivity with Bovine and Canine base on sequence identity.

Specificity

Munc 18

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Syntaxin-BP1 Antibody - BSA Free

Western Blot: Syntaxin-BP1 AntibodyBSA Free [NB120-3451]

Western Blot: Syntaxin-BP1 AntibodyBSA Free [NB120-3451]

Western Blot: Syntaxin-BP1 Antibody [NB120-3451] - Analysis of rat brain homogenate immunoprecipitated. 1. Extract only. 2-4. 750 ug of extract immunoprecipitated with 1 ug, 5 ug, and 10 ug of PA1-742, respectively.

Applications for Syntaxin-BP1 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:10-1:500

Immunohistochemistry

1:10 - 1:500

Immunohistochemistry-Frozen

1:10 - 1:500

Immunoprecipitation

1:10 - 1:500

Western Blot

1 ug/ml
Application Notes
WB: Detects an approx. 67 kDa protein representing Munc-18 from rat whole brain extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Syntaxin-BP1

Munc-18 is a cytosolic brain protein of ~67 kDa which plays a key role in vesicle membrane fusion events with the plasma membrane. Functional interactions have been demonstrated to exist between Munc-18, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin. Munc-18 is the mammalian homologue of the C. elegans gene unc-18. Mutations in Munc-18 can result in accumulations of acetylcholine and paralytic phenotype suggestive of a neurotransmitter release defect. Munc-18 thus appears to be required by the synaptic vesicle fusion complex. Two Munc-18 isoforms have recently been identified. Munc-18-1 has been shown to be primarily expressed in brain, while Munc-18-2 is expressed in most tissues.

Long Name

Syntaxin-binding Protein 1

Alternate Names

EIEE4, p67, rbSec1, STXBP1, SyntaxinBP1, UNC18

Entrez Gene IDs

25558 (Rat)

Gene Symbol

STXBP1

Additional Syntaxin-BP1 Products

Product Documents for Syntaxin-BP1 Antibody - BSA Free

Certificate of Analysis

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Product Specific Notices for Syntaxin-BP1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

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