T 98475

Catalog # Availability Size / Price Qty
2519/1
T 98475 | CAS No. 199119-18-1 | GnRH Antagonist
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Description: GnRH receptor antagonist

Chemical Name: 7-[(2,6-Difluorophenyl)methyl]-4,7-dihydro-2-[4-[(2-methyl-1-oxopropyl)amino]phenyl]-3-[[methyl(phenylmethyl)amino]methyl]-4-oxo-thieno[2,3-b]pyridine-5-carboxylic acid 1-methylethyl ester

Purity: ≥98%

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Biological Activity

Potent, orally active and non-peptide gonadotropin-releasing hormone (GnRH, LHRH) receptor antagonist (IC50 values are 0.2, 4.0 and 60 nM for human, monkey and rat GnRH receptors respectively). Inhibits LH release in vitro (IC50 = 100 nM) and reduces plasma LH concentration in castrated male cynomolgus monkeys.

Technical Data

M.Wt:
657.77
Formula:
C37H37F2N3O4S
Solubility:
Soluble to 50 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
199119-18-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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