TACA
Chemical Name: trans-4-Aminocrotonic acid
Biological Activity
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists.
Chebib et al.
Br.J.Pharmacol., 1997;122:1551 -
cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation.
Johnston et al.
J.Neurochem., 1975;24:157 -
GABAC receptors: relatively simple transmitter-gated ion channels.
Johnston et al.
TiPS, 1996;17:319
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Citation for TACA
The citations listed below are publications that use Tocris products. Selected citations for TACA include:
1 Citation: Showing 1 - 1
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Effects of a metabotropic glutamate 1 receptor antagonist on light responses of retinal ganglion cells in a rat model of retinitis pigmentosa.
Authors: Jensen
PLoS One 2013;8:e79126
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