Catalog Number: 0181
Chemical Name: trans-4-Aminocrotonic acid
Biological Activity
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
Technical Data
  • M.Wt:
    101.1
  • Formula:
    C4H7NO2
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at RT
  • CAS No:
    38090-53-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists.
    Chebib et al.
    Br.J.Pharmacol., 1997;122:1551
  2. cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation.
    Johnston et al.
    J.Neurochem., 1975;24:157
  3. GABAC receptors: relatively simple transmitter-gated ion channels.
    Johnston et al.
    TiPS, 1996;17:319

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