TACS-XL In Situ Apoptosis Detection Kit - DAB

Catalog # Availability Size / Price Qty
4828-30-DK
Product Details
Citations (15)
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TACS-XL In Situ Apoptosis Detection Kit - DAB Summary

A complete kit for the in situ detection of DNA fragmentation.

Key Benefits

• Robust method for in situ apoptosis detection
• Uses BrdU-based methods
• Precise cellular labeling
• Signal enhancing methods results in high signal-to-noise ratio

Why Use the TACS-XL In Situ Apoptosis Detection Kit - DAB?

TACS•XL DAB Kit is a complete kit for the in situ detection of DNA fragmentation.  This modified TUNEL assay  kit is based on the  incorporation of bromodeoxyuridine (BrdU) at the 3’ OH ends of the DNA fragments that are formed during apoptosis and a specific antibody to BrdU resulting in a high signal-to-noise ratio and less sensitivity to protease-induced false positive labeling than digoxigenin or biotin-based kits.

Kit Contents

• Proteinase K
• Streptavidin-HRP
• Diaminobenzidine
• DAB Enhancer
• TACS-Nuclease
• TACS-Nuclease Buffer
• Methyl Green 1%
• TACS 2 TdT Labeling Buffer
• TACS 2 TdT Stop Buffer
• TdT Enzyme
• B-dNTP Mix
• anti-BrdU antibody
• Strep-Diluent
• Cytonin

Specifications

Shipping Conditions
The components for this kit may require different storage/shipping temperatures and may arrive in separate packaging. Upon receipt, store products immediately at the temperature recommended on the product labels.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Multi-species

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Citations for TACS-XL In Situ Apoptosis Detection Kit - DAB

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. Repurposing Potential of Riluzole as an ITAF Inhibitor in mTOR Therapy Resistant Glioblastoma
    Authors: A Benavides-, JT Saunders, B Holmes, RN Nishimura, A Lichtenste, J Gera
    Int J Mol Sci, 2020;21(1):.  2020
  2. Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
    Authors: C Xue, Y Chen, DN Hu, C Iacob, C Lu, Z Huang
    Oncol Lett, 2016;12(6):4813-4820.  2016
  3. Surgery combined with controlled-release doxorubicin silk films as a treatment strategy in an orthotopic neuroblastoma mouse model.
    Authors: Chiu B, Coburn J, Pilichowska M, Holcroft C, Seib F, Charest A, Kaplan D
    Br J Cancer, 2014;111(4):708-15.  2014
  4. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
    Authors: Long, Lu, Yang, Xudong, Southwood, Mark, Lu, Junyu, Marciniak, Stefan J, Dunmore, Benjamin, Morrell, Nicholas
    Circ Res, 2013;112(8):1159-70.  2013
  5. Indirubin derivative E804 inhibits angiogenesis.
    BMC Cancer, 2012;12(0):164.  2012
  6. Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration.
    Authors: Murakami Y, Ikeda Y, Yonemitsu Y, Onimaru M, Nakagawa K, Kohno R, Miyazaki M, Hisatomi T, Nakamura M, Yabe T, Hasegawa M, Ishibashi T, Sueishi K
    Am. J. Pathol., 2008;173(5):1326-38.  2008
  7. Lignan transformation by gut bacteria lowers tumor burden in a gnotobiotic rat model of breast cancer.
    Authors: Mabrok H, Klopfleisch R, Ghanem K, Clavel T, Blaut M, Loh G
    Carcinogenesis, 0;33(1):203-8.  0
  8. Persistent effect of mTOR inhibition on preneoplastic foci progression and gene expression in a rat model of hepatocellular carcinoma.
    Authors: Francois-Vaughan H, Adebayo A, Brilliant K, Parry N, Gruppuso P, Sanders J
    Carcinogenesis, 0;37(4):408-419.  0
  9. In vivo tungsten exposure alters B-cell development and increases DNA damage in murine bone marrow.
    Authors: Kelly A, Lemaire M, Young Y, Eustache J, Guilbert C, Molina M, Mann K
    Toxicol Sci, 0;131(2):434-46.  0
  10. Hepatic serum amyloid A1 aggravates T cell-mediated hepatitis by inducing chemokines via Toll-like receptor 2 in mice.
    Authors: Ji Y, Kim H, Bae K, Lee S, Kim M, Ryoo Z
    J Biol Chem, 0;290(20):12804-11.  0
  11. Specific blockade of Rictor-mTOR association inhibits mTORC2 activity and is cytotoxic in glioblastoma.
    Authors: Benavides-Serrato A, Lee J, Holmes B, Landon K, Bashir T, Jung M, Lichtenstein A, Gera J
    PLoS ONE, 0;12(4):e0176599.  0
  12. Anti-YKL-40 antibody and ionizing irradiation synergistically inhibit tumor vascularization and malignancy in glioblastoma.
    Authors: Shao R, Francescone R, Ngernyuang N, Bentley B, Taylor S, Moral L, Yan W
    Carcinogenesis, 0;35(2):373-82.  0
  13. Inhibition of SAPK2/p38 enhances sensitivity to mTORC1 inhibition by blocking IRES-mediated translation initiation in glioblastoma.
    Authors: Cloninger C, Bernath A, Bashir T, Holmes B, Artinian N, Ruegg T, Anderson L, Masri J, Lichtenstein A, Gera J
    Mol Cancer Ther, 0;10(12):2244-56.  0
  14. Cellular interactions of the phosphorylated form of AKT in prostate cancer.
    Authors: Hammerich K, Frolov A, Li R, Ittmann M, Ayala G
    Hum Pathol, 0;63(0):98-109.  0
  15. Mechanistic Target of Rapamycin (mTOR) Inhibition Synergizes with Reduced Internal Ribosome Entry Site (IRES)-mediated Translation of Cyclin D1 and c-MYC mRNAs to Treat Glioblastoma.
    Authors: Holmes B, Lee J, Landon K, Benavides-Serrato A, Bashir T, Jung M, Lichtenstein A, Gera J
    J Biol Chem, 0;291(27):14146-59.  0

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