TACS XTT Cell Proliferation Assay
TACS XTT Cell Proliferation Assay Summary
Key Benefits
• Allows measurement of cell proliferation, cell viability or cytotoxicity.
• Rapid determination in microplates (no solubilization step as in an MTT assay).
• Reproducible and sensitive results.
• No radioactivity.
• Ideal for high throughput assays (no washing or other steps that can cause cell loss and variability).
Why Use the TACS XTT Cell Proliferation Assay?
The XTT Cell Proliferation Assay (XTT-CPA) is a sensitive kit for the measurement of cell proliferation. Cleavage of the tetrazolium salt to formazan occurs via the succinate-tetrazolium reductase system in the mitochondria of metabolically active cells.
Kit Contents
• XTT Reagent
• XTT Activator
Specifications
Limitations
For research use only. Not for diagnositic use.
Product Datasheets
Data Example
Citations for TACS XTT Cell Proliferation Assay
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
19
Citations: Showing 1 - 10
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Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
Authors: SJ Chen, L Bao, K Keefer, S Shanmughap, L Chen, J Lee, J Wang, XQ Zhang, I Hirschler-, S Merali, C Merali, Y Imamura, S Dovat, M Madesh, JY Cheung, HG Wang, BA Miller
Cell Death Dis, 2020;11(4):247. 2020
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Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers
Authors: D Goody, SK Gupta, D Engelmann, A Spitschak, S Marquardt, S Mikkat, C Meier, C Hauser, JP Gundlach, JH Egberts, H Martin, T Schumacher, A Trauzold, O Wolkenhaue, S Logotheti, BM Pützer
Theranostics, 2019;9(5):1490-1509. 2019
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The BET inhibitor GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment
Authors: E Kim, E Ten Hacken, M Sivina, A Clarke, PA Thompson, N Jain, A Ferrajoli, Z Estrov, MJ Keating, WG Wierda, KN Bhalla, JA Burger
Leukemia, 2019;0(0):. 2019
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The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2
Authors: L Bao, F Festa, CS Freet, JP Lee, IM Hirschler-, SJ Chen, KA Keefer, HG Wang, AD Patterson, JY Cheung, BA Miller
Sci Rep, 2019;9(1):14132. 2019
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Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
Authors: HM Tunset, AJ Feuerherm, LM Selvik, B Johansen, SA Moestue
Int J Mol Sci, 2019;20(19):. 2019
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Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis
Authors: AS Alqahtani, WM Abdel-Mage, AA Shahat, MK Parvez, MS Al-Dosari, A Malik, MS Abdel-Kade, MS Alsaid
J Food Drug Anal, 2019;27(3):758-765. 2019
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Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats
Authors: MK Parvez, MS Al-Dosari, AH Arbab, P Alam, MS Alsaid, AA Khan
BMC Complement Altern Med, 2019;19(1):154. 2019
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Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines
Authors: AC Reiersølmo, TI Aarhus, S Eckelt, KG Nørsett, E Sundby, BH Hoff
Bioorg. Chem., 2019;88(0):102918. 2019
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Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
Authors: M Diedrichs-, S Niesik, CS Priglinger, SR Thurau, F Obermayr, S Sperl, G Wildner
J Neuroinflammation, 2018;15(1):54. 2018
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Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration
Authors: S Gilbert-Gi, A Gravel, S Artusi, SN Richter, N Wallaschek, BB Kaufer, L Flamand
J. Virol., 2017;0(0):. 2017
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Silibinin down-regulates expression of secreted phospholipase A2 enzymes in cancer cells.
Authors: Hagelgans A, Nacke B, Zamaraeva M, Siegert G, Menschikowski M
Anticancer Res, 2014;34(4):1723-9. 2014
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Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer.
Authors: Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, Ghiabi P, Lis R, Vidal F, Saleh A, Gotlieb W, Rafii S, Rafii A
Mol Cancer Ther, 0;13(12):3123-36. 0
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Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.
Authors: He B, Hoang T, Wang T, Ferris M, Taylor C, Tian X, Luo M, Tran D, Zhou J, Tatevian N, Luo F, Molina J, Blackburn M, Gomez T, Roos S, Rhoads J, Liu Y
J Exp Med, 0;214(1):107-123. 0
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Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation.
Authors: Tagaya Y, Miura A, Okada S, Ohshima K, Mori M
Endocrinology, 0;153(7):3308-19. 0
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Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.
Authors: Bao L, Chen S, Conrad K, Keefer K, Abraham T, Lee J, Wang J, Zhang X, Hirschler-Laszkiewicz I, Wang H, Dovat S, Gans B, Madesh M, Cheung J, Miller B
J Biol Chem, 0;291(47):24449-24464. 0
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Methotraxate-Loaded Hybrid Nanoconstructs Target Vascular Lesions and Inhibit Atherosclerosis Progression in ApoE<sup>-/-</sup> Mice.
Authors: Stigliano C, Ramirez M, Singh J, Aryal S, Key J, Blanco E, Decuzzi P
Adv Healthc Mater, 0;6(13):. 0
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Blockade of CCR5 receptor prevents M2 microglia phenotype in a microglia-glioma paradigm.
Authors: Laudati E, Curro D, Navarra P, Lisi L
Neurochem Int, 0;108(0):100-108. 0
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A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2alpha.
Authors: Chen S, Hoffman N, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang X, Song J, Barrero C, Shi Y, Kawasawa Y, Bayerl M, Sun T, Barbour M, Wang H, Madesh M, Cheung J, Miller B
J Biol Chem, 0;289(52):36284-302. 0
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Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kdelta/gamma.
Authors: Davis R, Moore E, Clavijo P, Friedman J, Cash H, Chen Z, Silvin C, Van Waes C, Allen C
Cancer Res, 0;77(10):2607-2619. 0
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