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TACS XTT Cell Proliferation Assay

4891-025-K 19 Citations Datasheet / COA / SDS
A sensitive kit for the measurement of cell proliferation using XTT
Catalog # Availability Size / Price Qty
4891-025-K
TACS XTT Cell Proliferation/Viability Assay_4891-025-K
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Citations (19)
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TACS XTT Cell Proliferation Assay Summary

Provides a sensitive kit for the measurement of cell proliferation based upon the reduction of the tetrazolium salt, 2,3-Bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide.

Key Benefits

• Allows measurement of cell proliferation, cell viability or cytotoxicity.
• Rapid determination in microplates (no solubilization step as in an MTT assay).
• Reproducible and sensitive results.
• No radioactivity.
• Ideal for high throughput assays (no washing or other steps that can cause cell loss and variability).

Why Use the TACS XTT Cell Proliferation Assay?

The XTT Cell Proliferation Assay (XTT-CPA) is a sensitive kit for the measurement of cell proliferation. Cleavage of the tetrazolium salt to formazan occurs via the succinate-tetrazolium reductase system in the mitochondria of metabolically active cells.

Kit Contents

• XTT Reagent
• XTT Activator

Specifications

Shipping Conditions
The components for this kit may require different storage/shipping temperatures and may arrive in separate packaging. Upon receipt, store products immediately at the temperature recommended on the product labels.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
N/A

Limitations

For research use only. Not for diagnositic use.

Product Datasheets

Product Datasheet
COA
SDS

Data Example

TACS XTT Cell Proliferation/Viability Assay_4891-025-K View Larger

Relative Cell Number Measured using the TACS XTT Cell Proliferation/Viability Assay. Murine WEHI cells were counted and serial diluted in a microplate using 100 µL of the listed densities. Cells were incubated with XTT for 6 hours at 27 °C and absorbance was read using an ELISA plate reader.

Citations for TACS XTT Cell Proliferation Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Transient receptor potential ion channel TRPM2 promotes AML proliferation and survival through modulation of mitochondrial function, ROS, and autophagy
    Authors: SJ Chen, L Bao, K Keefer, S Shanmughap, L Chen, J Lee, J Wang, XQ Zhang, I Hirschler-, S Merali, C Merali, Y Imamura, S Dovat, M Madesh, JY Cheung, HG Wang, BA Miller
    Cell Death Dis, 2020;11(4):247.  2020
  2. Drug Repositioning Inferred from E2F1-Coregulator Interactions Studies for the Prevention and Treatment of Metastatic Cancers
    Authors: D Goody, SK Gupta, D Engelmann, A Spitschak, S Marquardt, S Mikkat, C Meier, C Hauser, JP Gundlach, JH Egberts, H Martin, T Schumacher, A Trauzold, O Wolkenhaue, S Logotheti, BM Pützer
    Theranostics, 2019;9(5):1490-1509.  2019
  3. The BET inhibitor GS-5829 targets chronic lymphocytic leukemia cells and their supportive microenvironment
    Authors: E Kim, E Ten Hacken, M Sivina, A Clarke, PA Thompson, N Jain, A Ferrajoli, Z Estrov, MJ Keating, WG Wierda, KN Bhalla, JA Burger
    Leukemia, 2019;0(0):.  2019
  4. The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2
    Authors: L Bao, F Festa, CS Freet, JP Lee, IM Hirschler-, SJ Chen, KA Keefer, HG Wang, AD Patterson, JY Cheung, BA Miller
    Sci Rep, 2019;9(1):14132.  2019
  5. Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells
    Authors: HM Tunset, AJ Feuerherm, LM Selvik, B Johansen, SA Moestue
    Int J Mol Sci, 2019;20(19):.  2019
  6. Proanthocyanidins from the stem bark of Rhus tripartita ameliorate methylgloxal-induced endothelial cell apoptosis
    Authors: AS Alqahtani, WM Abdel-Mage, AA Shahat, MK Parvez, MS Al-Dosari, A Malik, MS Abdel-Kade, MS Alsaid
    J Food Drug Anal, 2019;27(3):758-765.  2019
  7. Hepatoprotective effect of Solanum surattense leaf extract against chemical- induced oxidative and apoptotic injury in rats
    Authors: MK Parvez, MS Al-Dosari, AH Arbab, P Alam, MS Alsaid, AA Khan
    BMC Complement Altern Med, 2019;19(1):154.  2019
  8. Potent and selective EGFR inhibitors based on 5-aryl-7H-pyrrolopyrimidin-4-amines
    Authors: AC Reiersølmo, TI Aarhus, S Eckelt, KG Nørsett, E Sundby, BH Hoff
    Bioorg. Chem., 2019;88(0):102918.  2019
  9. Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells
    Authors: M Diedrichs-, S Niesik, CS Priglinger, SR Thurau, F Obermayr, S Sperl, G Wildner
    J Neuroinflammation, 2018;15(1):54.  2018
  10. Stabilization of telomere G-quadruplexes interferes with human herpesvirus 6A chromosomal integration
    Authors: S Gilbert-Gi, A Gravel, S Artusi, SN Richter, N Wallaschek, BB Kaufer, L Flamand
    J. Virol., 2017;0(0):.  2017
  11. Silibinin down-regulates expression of secreted phospholipase A2 enzymes in cancer cells.
    Authors: Hagelgans A, Nacke B, Zamaraeva M, Siegert G, Menschikowski M
    Anticancer Res, 2014;34(4):1723-9.  2014
  12. Akt-activated endothelium constitutes the niche for residual disease and resistance to bevacizumab in ovarian cancer.
    Authors: Guerrouahen B, Pasquier J, Kaoud N, Maleki M, Beauchamp M, Yasmeen A, Ghiabi P, Lis R, Vidal F, Saleh A, Gotlieb W, Rafii S, Rafii A
    Mol Cancer Ther, 0;13(12):3123-36.  0
  13. Resetting microbiota by Lactobacillus reuteri inhibits T reg deficiency-induced autoimmunity via adenosine A2A receptors.
    Authors: He B, Hoang T, Wang T, Ferris M, Taylor C, Tian X, Luo M, Tran D, Zhou J, Tatevian N, Luo F, Molina J, Blackburn M, Gomez T, Roos S, Rhoads J, Liu Y
    J Exp Med, 0;214(1):107-123.  0
  14. Nucleobindin-2 is a positive modulator of EGF-dependent signals leading to enhancement of cell growth and suppression of adipocyte differentiation.
    Authors: Tagaya Y, Miura A, Okada S, Ohshima K, Mori M
    Endocrinology, 0;153(7):3308-19.  0
  15. Depletion of the Human Ion Channel TRPM2 in Neuroblastoma Demonstrates Its Key Role in Cell Survival through Modulation of Mitochondrial Reactive Oxygen Species and Bioenergetics.
    Authors: Bao L, Chen S, Conrad K, Keefer K, Abraham T, Lee J, Wang J, Zhang X, Hirschler-Laszkiewicz I, Wang H, Dovat S, Gans B, Madesh M, Cheung J, Miller B
    J Biol Chem, 0;291(47):24449-24464.  0
  16. Methotraxate-Loaded Hybrid Nanoconstructs Target Vascular Lesions and Inhibit Atherosclerosis Progression in ApoE<sup>-/-</sup> Mice.
    Authors: Stigliano C, Ramirez M, Singh J, Aryal S, Key J, Blanco E, Decuzzi P
    Adv Healthc Mater, 0;6(13):.  0
  17. Blockade of CCR5 receptor prevents M2 microglia phenotype in a microglia-glioma paradigm.
    Authors: Laudati E, Curro D, Navarra P, Lisi L
    Neurochem Int, 0;108(0):100-108.  0
  18. A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2alpha.
    Authors: Chen S, Hoffman N, Shanmughapriya S, Bao L, Keefer K, Conrad K, Merali S, Takahashi Y, Abraham T, Hirschler-Laszkiewicz I, Wang J, Zhang X, Song J, Barrero C, Shi Y, Kawasawa Y, Bayerl M, Sun T, Barbour M, Wang H, Madesh M, Cheung J, Miller B
    J Biol Chem, 0;289(52):36284-302.  0
  19. Anti-PD-L1 Efficacy Can Be Enhanced by Inhibition of Myeloid-Derived Suppressor Cells with a Selective Inhibitor of PI3Kdelta/gamma.
    Authors: Davis R, Moore E, Clavijo P, Friedman J, Cash H, Chen Z, Silvin C, Van Waes C, Allen C
    Cancer Res, 0;77(10):2607-2619.  0

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