Catalog Number: 2672
Alternate Names: TA 0910
Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
Biological Activity
Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
  • Storage:
    Store at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety.
    Suzuki et al.
    J.Med.Chem., 1990;33:2130
  2. Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.
    Urayama et al.
    Life Sci., 2002;72:601
  3. The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.
    Tanabe et al.
    Br.J.Pharmacol., 2007;150:403

The citations listed below are publications that use Tocris products. Selected citations for Taltirelin include:

Showing Results 1 - 1 of 1

  1. Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor.
    Authors: Thirunarayanan Et al.
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