Chemical Name: N-[[(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinyl]carbonyl]-L-histidyl-L-prolinamide
Biological ActivityTaltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective.
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For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Synthesis and central nervous system actions of thyrotropin-releasing hormone analogues containing a dihydroorotic acid moiety.
Suzuki et al.
Neuroprotective effect and brain receptor binding of taltirelin, a novel thyrotropin-releasing hormone (TRH) analogue, in transient forebrain ischemia of C57BL/6J mice.
Urayama et al.
Life Sci., 2002;72:601
The synthetic TRH analogue taltirelin exerts modality-specific antinociceptive effects via distinct descending monoaminergic systems.
Tanabe et al.
Citation for Taltirelin
The citations listed below are publications that use Tocris products. Selected citations for Taltirelin include:
1 Citation: Showing 1 - 1
Taltirelin is a superagonist at the human thyrotropin-releasing hormone receptor.
Authors: Thirunarayanan Et al.
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