Tariquidar dihydrochloride

Key Product Details

Product Description

Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC₅₀ = 5.1 nM). Reverses drug resistance in multiple MDR cell lines. Acts as a substrate for breast cancer resistance protein (BCRP) at low concentrations and acts as an inhibitor of BCRP when used at >100 nM concentration. Potentiates the cytotoxic effects of doxorubicin (Cat. No. 2252) and mitoxantrone (Cat. No. 4250) in vitro.

Product Specifications for Tariquidar dihydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Tariquidar dihydrochloride

The following data is based on the product molecular weight 719.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.78 mL	13.90 mL	27.79 mL
2.5 mM	0.56 mL	2.78 mL	5.56 mL
5 mM	0.28 mL	1.39 mL	2.78 mL
25 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Loo Mapping the binding site of the inhibitor Tariquidar that stabilizes the first transmembrane domain of P-glycoprotein. J.Biol.Chem. 2015 PMID: 26507655
• Kannan The "specific" P-glycoprotein inhibitor Tariquidar is also a substrate and an inhibitor for breast cancer resistance protein (BCRP/ABCG2). ACS Chem.Neurosci. 2011 PMID: 22778859

Product Documents for Tariquidar dihydrochloride