Catalog Number: 2669
Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[,6.03,10.05,9.08,11]dodecan-3-ol
Biological Activity
High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 50 mM in DMSO with gentle warming and to 50 mM in ethanol with gentle warming
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects.
    Liu et al.
    Eur.J.Pharmacol., 2007;555:37
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