TC 1

Catalog # Availability Size / Price Qty
2669/10
2669/50
TC 1 | CAS No. 362512-81-0 | Sigma1 Receptor Ligands
1 Image
Description: High affinity σ1 ligand

Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecan-3-ol

Purity: ≥99%

Product Details
Reviews

Biological Activity

High affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.

Technical Data

M.Wt:
297.37
Formula:
C19H20FNO
Solubility:
Soluble to 50 mM in DMSO with gentle warming and to 50 mM in ethanol with gentle warming
Purity:
≥99%
Storage:
Store at RT
CAS No:
362512-81-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects.
    Liu et al.
    Eur.J.Pharmacol., 2007;555:37

Product Datasheets

or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for TC 1

There are currently no reviews for this product. Be the first to review TC 1 and earn rewards!

Have you used TC 1?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.