High affinity σ1
receptor ligand that displays selectivity over σ2
values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki
> 10 μ
M) and low affinity for dopamine D2
= 1226 nM). Attenuates cocaine-induced locomotor activity in mice.
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All Tocris products are intended for laboratory research use only.
Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects.
Liu et al.