TC 1

Catalog #: 2669 Datasheet / COA / SDS

Discontinued Product

2669 has been discontinued.
View all Sigma1 Receptor Ligands products.
TC 1 | CAS No. 362512-81-0 | Sigma1 Receptor Ligands
1 Image
Description: High affinity σ1 ligand

Chemical Name: (N-(3'-Fluorophenyl)ethyl-4-azahexacyclo[,6.03,10.05,9.08,11]dodecan-3-ol

Purity: ≥99%

Product Details

Biological Activity

TC 1 is a high affinity σ1 receptor ligand that displays selectivity over σ2 receptors (Ki values are 10 and 370 nM respectively). Exhibits low affinity for dopamine (DAT), serotonin (SERT) and noradrenalin (NET) transporters (Ki > 10 μM) and low affinity for dopamine D2 receptors (Ki = 1226 nM). Attenuates cocaine-induced locomotor activity in mice.

Technical Data

Soluble to 50 mM in DMSO with gentle warming and to 50 mM in ethanol with gentle warming
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Trishomocubanes: novel σ ligands modulate cocaine-induced behavioural effects.
    Liu et al.
    Eur.J.Pharmacol., 2007;555:37

Product Datasheets

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