Catalog Number: 5049
Chemical Name: 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole
Biological Activity
Dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.
Technical Data
  • M.Wt:
    409.46
  • Formula:
    C20H19N5O3S
  • Solubility:
    Soluble to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    865565-29-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. [1,2,4]Triazole-3-ylsulfanylmethyl)-3-phenyl-[1,2,4]oxadiazoles: antagonists of the wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding.
    Shultz et al.
    J.Med.Chem., 2012;55:1127

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