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TC-E 5001

5049 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5049/10
5049/50
Tankyrase Inhibitors Small Molecule
1 Image
Description: Potent tankyrase inhibitor

Chemical Name: 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole

Purity: ≥98%

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Biological Activity

Dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.

Technical Data

M.Wt:
409.46
Formula:
C20H19N5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
865565-29-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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