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TC-E 5001

5049 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5049/10
5049/50
Cat.No. 5049 - TC-E 5001 | C20H19N5O3S | CAS No. 865565-29-3
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Description: Potent tankyrase inhibitor

Chemical Name: 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole

Purity: ≥98%

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Biological Activity

Dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 μM). Inhibits Wnt signaling and stabilizes Axin2 levels.

Technical Data

M.Wt:
409.46
Formula:
C20H19N5O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
865565-29-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

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