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TC-E 5006

4898 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4898/10
4898/50
gamma-Secretase Modulators Small Molecule
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Description: γ-secretase modulator; reduces Aβ42 levels

Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid

Purity: ≥98%

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Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Technical Data

M.Wt:
499.54
Formula:
C29H29F4NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1257395-14-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator.
    Peng et al.
    ACS Med.Chem.Lett., 2011;2:786

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