Catalog Number: 4898
Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid
Biological Activity
γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator.
    Peng et al.
    ACS Med.Chem.Lett., 2011;2:786
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