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TC-E 5006

4898 1 Review Datasheet / COA / SDS
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TC-E 5006 | CAS No. 1257395-14-4 | gamma-Secretase Modulators
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Description: γ-secretase modulator; reduces Aβ42 levels

Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid

Purity: ≥98%

Product Details
Reviews (1)
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

TC-E 5006 is a γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Technical Data

M.Wt:
499.54
Formula:
C29H29F4NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1257395-14-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator.
    Peng et al.
    ACS Med.Chem.Lett., 2011;2:786

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Mice in vitro study
By Anonymous on 09/05/2021
Application: Species: Mouse

Mice in vitro study

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