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TC-E 5006

4898 Datasheet / COA / SDS
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4898/50
Cat.No. 4898 - TC-E 5006 | C29H29F4NO2 | CAS No. 1257395-14-4
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Description: γ-secretase modulator; reduces Aβ42 levels

Chemical Name: 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid

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Biological Activity

γ-secretase modulator. Reduces Aβ42 levels in vitro (EC50 = 390 nM) and in vivo. Orally bioavailable.

Technical Data

Formula:
C29H29F4NO2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
CAS No:
1257395-14-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.

Background References

  1. Discovery of BIIB042, a potent, selective, and orally bioavailable γ-secretase modulator.
    Peng et al.
    ACS Med.Chem.Lett., 2011;2:786

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