TC-E 5007

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TC-E 5007 | Additional Synthetic Protease Inhibitors
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Description: Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor
Alternative Names: allo-I1e-isoindoline

Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride

Product Details
Reviews (2)

Biological Activity

Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
Store the unopened product at room temperature. Do not use past expiration date.

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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TC-E 5007 inhibits CaMKII phosphorylation in cardiomyocytes
By Christopher Trummer on 10/22/2018
Species: Mouse

HL-1 cardiomyocytes were treated with TC-E 5007 (1 µM) for 0-60 min and CaMKII phosphorylation was assessed using Western blot.

TC-E 5007 impairs Ca2+ transient relaxation
By Chintan Koyani on 10/13/2018
Species: Mouse

Representative Ca2+ transient traces of control and a TC-E 5007 (2 µM and 2 h for all)-treated mouse ventricular cardiomyocytes stimulated at 1 Hz frequency. TC-E 5007 increased Ca2+ transient relaxation tau.

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