Catalog Number: 5204
Alternate Names: allo-I1e-isoindoline
Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Biological Activity
Irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.
Technical Data
  • M.Wt:
    268.78
  • Formula:
    C14H20N2O.HCl
  • Solubility:
    Soluble to 100 mM in water and to 100 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at RT
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
    Lankas et al.
    Diabetes, 2005;54:2988
  2. Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.
    Wu et al.
    Biochem.Pharmacol., 2009;78:203
  3. Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.
    Van der Veken et al.
    J.Med.Chem., 2007;50:5568

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