Chemical Name: (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride
Biological ActivityIrreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 values are 145 and 242 nM respectively). Exhibits selectivity for DPP-8/9 over DPP-IV, DPP-2 and FAP.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
Lankas et al.
Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor.
Wu et al.
Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates.
Van der Veken et al.
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HL-1 cardiomyocytes were treated with TC-E 5007 (1 µM) for 0-60 min and CaMKII phosphorylation was assessed using Western blot.
Representative Ca2+ transient traces of control and a TC-E 5007 (2 µM and 2 h for all)-treated mouse ventricular cardiomyocytes stimulated at 1 Hz frequency. TC-E 5007 increased Ca2+ transient relaxation tau.