Potent and selective inhibitor of Aurora kinase A (IC50
= 3.4 nM); exhibits 1000-fold selectivity for Aurora kinase A over Aurora kinase B. Displays antiproliferative activity in HCT116 and HT29 cells (IC50
values are 0.19 and 2.9 μ
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All Tocris products are intended for laboratory research use only.
A class of 2,4-bisanilinopyrimidine Aurora A inhibitors with unusually high selectivity against Aurora B.
Aliagas-Martin et al.
Overcoming CML acquired resistance by specific inhibition of Aurora A kinse in the KCL-22 cell model.
Yuan et al.