TC-SP 14

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4363/10
4363/50
TC-SP 14 | CAS No. 1257093-40-5 | Sphingosine-1-phosphate Receptor Agonists
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Description: Potent S1P1 receptor agonist

Chemical Name: 1-[[3-Fluoro-4-[5-[(2-fluorophenyl)methyl]-2-benzothiazolyl]phenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥98%

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Biological Activity

Potent and selective S1P1 agonist (EC50 values are 0.042 and 3.47 μM for human S1P1 and S1P3 respectively). Attenuates immune response to antigen challenge and reduces circulating blood lymphocyte counts in a rodent model of delayed-type hypersensitivity. Orally bioavailable.

Technical Data

M.Wt:
450.5
Formula:
C25H20F2N2O2S
Solubility:
Soluble to 50 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
1257093-40-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Discovery of a potent, S1P3-sparing benzothiazole agonist of sphingosine-1-phosphate receptor 1 (S1P1).
    Lanman et al.
    ACS Med.Chem.Lett., 2011;2:102

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